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Q65VJ3 (MTLD_MANSM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:MS0410
OrganismMannheimia succiniciproducens (strain MBEL55E) [Complete proteome] [HAMAP]
Taxonomic identifier221988 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Basfia

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000011806

Regions

Nucleotide binding3 – 1412NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q65VJ3 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 1DB52CD506C77015

FASTA38242,344
        10         20         30         40         50         60 
MKALHFGAGN IGRGFIGKLL ADSGMQVIFA DVNDSVIDLL KSRRSYGVKI VGDSINTVER 

        70         80         90        100        110        120 
VTQVTGVNSK DETAIITLFN EVDLVTTAVG PNVLKIVAST FAKALEARIA GGNTKPLNII 

       130        140        150        160        170        180 
ACENMVRGTS FLKEQVFTHL NPDYKDKVEQ LIGFVDSAVD RIVPPVKPDA EDPLLVTVEE 

       190        200        210        220        230        240 
FSEWIVDQTQ FKGAIPDIKG MELTDNLMAF VERKLFTLNT GHAVTSYYGK FKGYKFVKES 

       250        260        270        280        290        300 
IEDESVKAFV KSVMQESGAV LIKRYGFDPQ AHAAYIEKIL KRFANPYLVD DVDRVGREPL 

       310        320        330        340        350        360 
RKLSYNDRLI KPLRGTIEYG LPNDNLIRAI ATALSYRNEN DPQALELAKS LAEAGVTQTI 

       370        380 
KKYTELQDEN VIARIAKAYE TL

« Hide

References

[1]"The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
Nat. Biotechnol. 22:1275-1281(2004) [PubMed: 15378067] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MBEL55E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016827 Genomic DNA. Translation: AAU37017.1.
RefSeqYP_087602.1. NC_006300.1.

3D structure databases

ProteinModelPortalQ65VJ3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ65VJ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3075487.
GenomeReviewsGene locus MS0410 in contig AE016827_GR.
KEGGmsu:MS0410.
NMPDRfig|221988.1.peg.390.
PATRIC22444222. VBIManSuc86752_0376.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHBG568825.
OMAFANTAVD.
PhylomeDBQ65VJ3.
ProtClustDBPRK02318.

Enzyme and pathway databases

BioCycMSUC221988:MS0410-MONOMER.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_MANSM
AccessionPrimary (citable) accession number: Q65VJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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