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Q65VI1

- LPXB_MANSM

UniProt

Q65VI1 - LPXB_MANSM

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciBMAN221988:GHGM-431-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:MS0422
    OrganismiMannheimia succiniciproducens (strain MBEL55E)
    Taxonomic identifieri221988 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
    ProteomesiUP000000607: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Lipid-A-disaccharide synthasePRO_0000255197Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi221988.MS0422.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65VI1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q65VI1-1 [UniParc]FASTAAdd to Basket

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    MRSIMENLIK NNPTIAIVAG EVSGDILGGG LIKALKVKYP QARFVGIAGK    50
    NMLAESCESL VDIEEIAVMG LVEILKHLPR LLKIRSDIVQ KLSALKPDIF 100
    IGIDSPEFNL YVEDRLKAQG IKTIHYVSPS VWAWRQNRIY KIAKATNLVL 150
    AFLPFEKAFY DRFNVPCRFI GHTMADAIPL NPNRTEACKM LNIDENQRYV 200
    AILAGSRGSE VEFLAEPFLQ TAQLLKRKYP DLKFLVPLVN EKRRRQFEQV 250
    KAKVAPELDL ILLDGHGRQA MIAAQATLLA SGTAALECML CKSPMVVGYR 300
    MKAATYWLAK RLVKTAYISL PNLLADEMLV PEMIQDECTP EKLVEKLSVY 350
    LDETESAVQN RQVLIQRFTE LHQLIQCDAD SQAAQAVADL LEGKVNG 397
    Length:397
    Mass (Da):44,438
    Last modified:October 25, 2004 - v1
    Checksum:i35B713E7CAFC7778
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016827 Genomic DNA. Translation: AAU37029.1.
    RefSeqiWP_011199604.1. NC_006300.1.
    YP_087614.1. NC_006300.1.

    Genome annotation databases

    EnsemblBacteriaiAAU37029; AAU37029; MS0422.
    GeneIDi3076487.
    KEGGimsu:MS0422.
    PATRICi22444252. VBIManSuc86752_0388.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016827 Genomic DNA. Translation: AAU37029.1 .
    RefSeqi WP_011199604.1. NC_006300.1.
    YP_087614.1. NC_006300.1.

    3D structure databases

    ProteinModelPortali Q65VI1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 221988.MS0422.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU37029 ; AAU37029 ; MS0422 .
    GeneIDi 3076487.
    KEGGi msu:MS0422.
    PATRICi 22444252. VBIManSuc86752_0388.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci BMAN221988:GHGM-431-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
      Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
      Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MBEL55E.

    Entry informationi

    Entry nameiLPXB_MANSM
    AccessioniPrimary (citable) accession number: Q65VI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3