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Q65VI1

- LPXB_MANSM

UniProt

Q65VI1 - LPXB_MANSM

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, MS0422
Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBMAN221988:GHGM-431-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:MS0422
OrganismiMannheimia succiniciproducens (strain MBEL55E)
Taxonomic identifieri221988 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
ProteomesiUP000000607: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000255197Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi221988.MS0422.

Structurei

3D structure databases

ProteinModelPortaliQ65VI1.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65VI1-1 [UniParc]FASTAAdd to Basket

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MRSIMENLIK NNPTIAIVAG EVSGDILGGG LIKALKVKYP QARFVGIAGK    50
NMLAESCESL VDIEEIAVMG LVEILKHLPR LLKIRSDIVQ KLSALKPDIF 100
IGIDSPEFNL YVEDRLKAQG IKTIHYVSPS VWAWRQNRIY KIAKATNLVL 150
AFLPFEKAFY DRFNVPCRFI GHTMADAIPL NPNRTEACKM LNIDENQRYV 200
AILAGSRGSE VEFLAEPFLQ TAQLLKRKYP DLKFLVPLVN EKRRRQFEQV 250
KAKVAPELDL ILLDGHGRQA MIAAQATLLA SGTAALECML CKSPMVVGYR 300
MKAATYWLAK RLVKTAYISL PNLLADEMLV PEMIQDECTP EKLVEKLSVY 350
LDETESAVQN RQVLIQRFTE LHQLIQCDAD SQAAQAVADL LEGKVNG 397
Length:397
Mass (Da):44,438
Last modified:October 25, 2004 - v1
Checksum:i35B713E7CAFC7778
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016827 Genomic DNA. Translation: AAU37029.1.
RefSeqiWP_011199604.1. NC_006300.1.
YP_087614.1. NC_006300.1.

Genome annotation databases

EnsemblBacteriaiAAU37029; AAU37029; MS0422.
GeneIDi3076487.
KEGGimsu:MS0422.
PATRICi22444252. VBIManSuc86752_0388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016827 Genomic DNA. Translation: AAU37029.1 .
RefSeqi WP_011199604.1. NC_006300.1.
YP_087614.1. NC_006300.1.

3D structure databases

ProteinModelPortali Q65VI1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 221988.MS0422.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU37029 ; AAU37029 ; MS0422 .
GeneIDi 3076487.
KEGGi msu:MS0422.
PATRICi 22444252. VBIManSuc86752_0388.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci BMAN221988:GHGM-431-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
    Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
    Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MBEL55E.

Entry informationi

Entry nameiLPXB_MANSM
AccessioniPrimary (citable) accession number: Q65VI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 25, 2004
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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