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Q65VI1

- LPXB_MANSM

UniProt

Q65VI1 - LPXB_MANSM

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBMAN221988:GHGM-431-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:MS0422
OrganismiMannheimia succiniciproducens (strain MBEL55E)
Taxonomic identifieri221988 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
ProteomesiUP000000607: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Lipid-A-disaccharide synthasePRO_0000255197Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi221988.MS0422.

Structurei

3D structure databases

ProteinModelPortaliQ65VI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65VI1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSIMENLIK NNPTIAIVAG EVSGDILGGG LIKALKVKYP QARFVGIAGK
60 70 80 90 100
NMLAESCESL VDIEEIAVMG LVEILKHLPR LLKIRSDIVQ KLSALKPDIF
110 120 130 140 150
IGIDSPEFNL YVEDRLKAQG IKTIHYVSPS VWAWRQNRIY KIAKATNLVL
160 170 180 190 200
AFLPFEKAFY DRFNVPCRFI GHTMADAIPL NPNRTEACKM LNIDENQRYV
210 220 230 240 250
AILAGSRGSE VEFLAEPFLQ TAQLLKRKYP DLKFLVPLVN EKRRRQFEQV
260 270 280 290 300
KAKVAPELDL ILLDGHGRQA MIAAQATLLA SGTAALECML CKSPMVVGYR
310 320 330 340 350
MKAATYWLAK RLVKTAYISL PNLLADEMLV PEMIQDECTP EKLVEKLSVY
360 370 380 390
LDETESAVQN RQVLIQRFTE LHQLIQCDAD SQAAQAVADL LEGKVNG
Length:397
Mass (Da):44,438
Last modified:October 25, 2004 - v1
Checksum:i35B713E7CAFC7778
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016827 Genomic DNA. Translation: AAU37029.1.
RefSeqiYP_087614.1. NC_006300.1.

Genome annotation databases

EnsemblBacteriaiAAU37029; AAU37029; MS0422.
GeneIDi3076487.
KEGGimsu:MS0422.
PATRICi22444252. VBIManSuc86752_0388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016827 Genomic DNA. Translation: AAU37029.1 .
RefSeqi YP_087614.1. NC_006300.1.

3D structure databases

ProteinModelPortali Q65VI1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 221988.MS0422.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU37029 ; AAU37029 ; MS0422 .
GeneIDi 3076487.
KEGGi msu:MS0422.
PATRICi 22444252. VBIManSuc86752_0388.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci BMAN221988:GHGM-431-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
    Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
    Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MBEL55E.

Entry informationi

Entry nameiLPXB_MANSM
AccessioniPrimary (citable) accession number: Q65VI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 25, 2004
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3