Q65V66 (UXUA_MANSM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	MS0537

Organism

Mannheimia succiniciproducens (strain MBEL55E) [Complete proteome] [HAMAP]

Taxonomic identifier

221988 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Basfia

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Mannonate dehydratase HAMAP MF_00106		PRO_0000170677

Sequences

	Sequence		Length	Mass (Da)
	Q65V66 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 1C3BD175ADB1EA75	FASTA	394	44,836
	10 20 30 40 50 60 MEQTWRWYGP NDPVSLADIR QAGATGIVNA LHHIPNGQVW SVEEIEKRKA IIEAAGLTWS 70 80 90 100 110 120 VVESVPVHEE IKTQTGNYKT WIENYKQTLR NLAQCGIDTV CYNFMPVLDW TRTDLAYELP 130 140 150 160 170 180 DGSKALRFDQ IAFAAFELHI LKRPGAEQTY TAEEQKQAKA YFDKMSDADI KQLTSNIIAG 190 200 210 220 230 240 LPGAEEGYTL EEFQGQLDRY KDISPEKFRT HLAYFLNEII PVAQEVGIKM AVHPDDPPRP 250 260 270 280 290 300 ILGLPRIVST IEDMQWYVDT CDLPANGFTM CTGSYGVRAD NDLVKMTEKF GDRIYFAHLR 310 320 330 340 350 360 STCREDNPLT FHEAAHLQGD VDMFNVVKAL LTEEYRRKAN GETRLIPMRP DHGHQMLDDL 370 380 390 KKKTNPGYSA IGRLKGLAEF RGLEMALKKV FFEK

References

[1]

"The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens." Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J. Nat. Biotechnol. 22:1275-1281(2004) [PubMed: 15378067] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MBEL55E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016827 Genomic DNA. Translation: AAU37144.1.
RefSeq	YP_087729.1. NC_006300.1.
3D structure databases
ProteinModelPortal	Q65V66.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65V66.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3075799.
GenomeReviews	Gene locus MS0537 in contig AE016827_GR.
KEGG	msu:MS0537.
NMPDR	fig|221988.1.peg.508.
PATRIC	22444488. VBIManSuc86752_0492.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1312.
HOGENOM	HBG585927.
OMA	VHEEIKT.
PhylomeDB	Q65V66.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	MSUC221988:MS0537-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_MANSM

Accession

Primary (citable) accession number: Q65V66

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program