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Q65UL1

- NADK_MANSM

UniProt

Q65UL1 - NADK_MANSM

Protein

NAD kinase

Gene

nadK

Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 2 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei81 – 811Proton acceptorUniRule annotation
    Binding sitei166 – 1661NADUniRule annotation
    Binding sitei183 – 1831NADUniRule annotation
    Binding sitei185 – 1851NADUniRule annotation
    Binding sitei256 – 2561NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi81 – 822NADUniRule annotation
    Nucleotide bindingi155 – 1562NADUniRule annotation
    Nucleotide bindingi196 – 2016NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBMAN221988:GHGM-769-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:MS0742
    OrganismiMannheimia succiniciproducens (strain MBEL55E)
    Taxonomic identifieri221988 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
    ProteomesiUP000000607: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301NAD kinasePRO_0000229652Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi221988.MS0742.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65UL1.
    SMRiQ65UL1. Positions 12-301.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227221.
    KOiK00858.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q65UL1-1 [UniParc]FASTAAdd to Basket

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    MSQDSVKSLQ STFKTVGVVG RPRNDSTLQM HKNIFHWLCE QGYQVLVENE    50
    IGKALNLSEN HLASLDQIGQ HAQLAIVIGG DGNMLSHARI LCKYNTPLIG 100
    INRGNLGFLT DIDPKNAYAQ LEACLNGEFF VEERFLLEAV VKRHGETVAR 150
    GNAINELVIH PAKIAHMIDF HVYIDDKFAF SQRSDGLIVA TPTGSTAYSL 200
    SAGGPILTPQ LNAIALVPMF PHTLSSRPLV VDGNSKISVN FAEYNIPQLE 250
    ISCDSQLALD ICCNDVVHIQ KSPYKLRLLH LHNYNYYNVL SSKLGWLKKL 300
    F 301
    Length:301
    Mass (Da):33,395
    Last modified:April 4, 2006 - v2
    Checksum:i366E806E6E2962C5
    GO

    Sequence cautioni

    The sequence AAU37349.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016827 Genomic DNA. Translation: AAU37349.1. Different initiation.
    RefSeqiYP_087934.1. NC_006300.1.

    Genome annotation databases

    EnsemblBacteriaiAAU37349; AAU37349; MS0742.
    GeneIDi3074970.
    KEGGimsu:MS0742.
    PATRICi22444877. VBIManSuc86752_0681.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016827 Genomic DNA. Translation: AAU37349.1 . Different initiation.
    RefSeqi YP_087934.1. NC_006300.1.

    3D structure databases

    ProteinModelPortali Q65UL1.
    SMRi Q65UL1. Positions 12-301.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 221988.MS0742.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU37349 ; AAU37349 ; MS0742 .
    GeneIDi 3074970.
    KEGGi msu:MS0742.
    PATRICi 22444877. VBIManSuc86752_0681.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227221.
    KOi K00858.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci BMAN221988:GHGM-769-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
      Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
      Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MBEL55E.

    Entry informationi

    Entry nameiNADK_MANSM
    AccessioniPrimary (citable) accession number: Q65UL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3