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Q65UL1

- NADK_MANSM

UniProt

Q65UL1 - NADK_MANSM

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Protein

NAD kinase

Gene
nadK, MS0742
Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei81 – 811Proton acceptor By similarity
Binding sitei166 – 1661NAD By similarity
Binding sitei183 – 1831NAD By similarity
Binding sitei185 – 1851NAD By similarity
Binding sitei256 – 2561NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi81 – 822NAD By similarity
Nucleotide bindingi155 – 1562NAD By similarity
Nucleotide bindingi196 – 2016NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciBMAN221988:GHGM-769-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:MS0742
OrganismiMannheimia succiniciproducens (strain MBEL55E)
Taxonomic identifieri221988 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
ProteomesiUP000000607: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301NAD kinaseUniRule annotationPRO_0000229652Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi221988.MS0742.

Structurei

3D structure databases

ProteinModelPortaliQ65UL1.
SMRiQ65UL1. Positions 12-301.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65UL1-1 [UniParc]FASTAAdd to Basket

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MSQDSVKSLQ STFKTVGVVG RPRNDSTLQM HKNIFHWLCE QGYQVLVENE    50
IGKALNLSEN HLASLDQIGQ HAQLAIVIGG DGNMLSHARI LCKYNTPLIG 100
INRGNLGFLT DIDPKNAYAQ LEACLNGEFF VEERFLLEAV VKRHGETVAR 150
GNAINELVIH PAKIAHMIDF HVYIDDKFAF SQRSDGLIVA TPTGSTAYSL 200
SAGGPILTPQ LNAIALVPMF PHTLSSRPLV VDGNSKISVN FAEYNIPQLE 250
ISCDSQLALD ICCNDVVHIQ KSPYKLRLLH LHNYNYYNVL SSKLGWLKKL 300
F 301
Length:301
Mass (Da):33,395
Last modified:April 4, 2006 - v2
Checksum:i366E806E6E2962C5
GO

Sequence cautioni

The sequence AAU37349.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016827 Genomic DNA. Translation: AAU37349.1. Different initiation.
RefSeqiYP_087934.1. NC_006300.1.

Genome annotation databases

EnsemblBacteriaiAAU37349; AAU37349; MS0742.
GeneIDi3074970.
KEGGimsu:MS0742.
PATRICi22444877. VBIManSuc86752_0681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016827 Genomic DNA. Translation: AAU37349.1 . Different initiation.
RefSeqi YP_087934.1. NC_006300.1.

3D structure databases

ProteinModelPortali Q65UL1.
SMRi Q65UL1. Positions 12-301.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 221988.MS0742.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU37349 ; AAU37349 ; MS0742 .
GeneIDi 3074970.
KEGGi msu:MS0742.
PATRICi 22444877. VBIManSuc86752_0681.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227221.
KOi K00858.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci BMAN221988:GHGM-769-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
    Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
    Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MBEL55E.

Entry informationi

Entry nameiNADK_MANSM
AccessioniPrimary (citable) accession number: Q65UL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: July 9, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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