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Protein

NAD kinase

Gene

nadK

Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei81Proton acceptorUniRule annotation1
Binding sitei166NADUniRule annotation1
Binding sitei183NADUniRule annotation1
Binding sitei185NADUniRule annotation1
Binding sitei256NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi81 – 82NADUniRule annotation2
Nucleotide bindingi155 – 156NADUniRule annotation2
Nucleotide bindingi196 – 201NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:MS0742
OrganismiMannheimia succiniciproducens (strain MBEL55E)
Taxonomic identifieri221988 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
Proteomesi
  • UP000000607 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296521 – 301NAD kinaseAdd BLAST301

Interactioni

Protein-protein interaction databases

STRINGi221988.MS0742

Structurei

3D structure databases

ProteinModelPortaliQ65UL1
SMRiQ65UL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227221
KOiK00858
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.301 hit
3.40.50.103302 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q65UL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQDSVKSLQ STFKTVGVVG RPRNDSTLQM HKNIFHWLCE QGYQVLVENE
60 70 80 90 100
IGKALNLSEN HLASLDQIGQ HAQLAIVIGG DGNMLSHARI LCKYNTPLIG
110 120 130 140 150
INRGNLGFLT DIDPKNAYAQ LEACLNGEFF VEERFLLEAV VKRHGETVAR
160 170 180 190 200
GNAINELVIH PAKIAHMIDF HVYIDDKFAF SQRSDGLIVA TPTGSTAYSL
210 220 230 240 250
SAGGPILTPQ LNAIALVPMF PHTLSSRPLV VDGNSKISVN FAEYNIPQLE
260 270 280 290 300
ISCDSQLALD ICCNDVVHIQ KSPYKLRLLH LHNYNYYNVL SSKLGWLKKL

F
Length:301
Mass (Da):33,395
Last modified:April 4, 2006 - v2
Checksum:i366E806E6E2962C5
GO

Sequence cautioni

The sequence AAU37349 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016827 Genomic DNA Translation: AAU37349.1 Different initiation.

Genome annotation databases

EnsemblBacteriaiAAU37349; AAU37349; MS0742
KEGGimsu:MS0742

Similar proteinsi

Entry informationi

Entry nameiNADK_MANSM
AccessioniPrimary (citable) accession number: Q65UL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: February 28, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome