Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi379 – 386ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Synonyms:mdlB
Ordered Locus Names:MS0932
OrganismiMannheimia succiniciproducens (strain MBEL55E)
Taxonomic identifieri221988 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
Proteomesi
  • UP000000607 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 49HelicalUniRule annotationAdd BLAST23
Transmembranei68 – 88HelicalUniRule annotationAdd BLAST21
Transmembranei142 – 162HelicalUniRule annotationAdd BLAST21
Transmembranei163 – 183HelicalUniRule annotationAdd BLAST21
Transmembranei255 – 275HelicalUniRule annotationAdd BLAST21
Transmembranei277 – 297HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925871 – 585Lipid A export ATP-binding/permease protein MsbAAdd BLAST585

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi221988.MS0932.

Structurei

3D structure databases

ProteinModelPortaliQ65U21.
SMRiQ65U21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 313ABC transmembrane type-1UniRule annotationAdd BLAST285
Domaini345 – 581ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OrthoDBiPOG091H00DB.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65U21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKLQENDLS TSQTFKRLWP TIAPFKIGLI AAAAALVLNA LTDSGLIYLL
60 70 80 90 100
KPLLDDGFGK ADTSFLKLMA VLVIVFIFIR GITSFISSYC LAWVSGKVVM
110 120 130 140 150
TMRRRLFKHL MYMPVSFFDQ NSTGRLLSRI TYDSEQVANS SSNALVTIVR
160 170 180 190 200
EGAYIISLLA VMIATSWQLS VVLFIIGPVI AVLIRLVSKI FRRLSKNMQN
210 220 230 240 250
SMGELTATAE QMLKGHKVVL SFGGQQIEEQ RFNEVSNDMR RKGMKMVVAD
260 270 280 290 300
AISDPIVQII ASLALSAVLY LATIPSIMSQ NLSAGSFTVV FSSMLAMLRP
310 320 330 340 350
LKSLTNVNSQ FQRGMAACQT LFDILDLDTE KDKGKYEAER VKGDVSFKDV
360 370 380 390 400
SFTYQGKDQP ALKHLSFDIP HGKTFALVGR SGSGKSTIAN LVTRFYDINQ
410 420 430 440 450
GEILLDGVNV QDYTLSNLRT HCSVVSQQVH LFNDTIANNI AYAAKDKYSR
460 470 480 490 500
EQIIAAAKAA HAMEFIEPLE NGLDTVIGEN GASLSGGQRQ RLAIARALLR
510 520 530 540 550
DSPVLILDEA TSALDTESER AIQAALEELQ KDRTVLVIAH RLSTIEKADE
560 570 580
ILVIDHGEIC ERGSHEELLA LNGAYKQLHK MQFNG
Length:585
Mass (Da):64,515
Last modified:February 1, 2005 - v2
Checksum:i8ADEAC9610C34AE7
GO

Sequence cautioni

The sequence AAU37539 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016827 Genomic DNA. Translation: AAU37539.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiAAU37539; AAU37539; MS0932.
KEGGimsu:MS0932.

Similar proteinsi

Entry informationi

Entry nameiMSBA_MANSM
AccessioniPrimary (citable) accession number: Q65U21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: June 7, 2017
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families