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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei545 – 5451UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBMAN221988:GHGM-1053-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:MS1017Imported
OrganismiMannheimia succiniciproducens (strain MBEL55E)Imported
Taxonomic identifieri221988 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
ProteomesiUP000000607: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi221988.MS1017.

Structurei

3D structure databases

ProteinModelPortaliQ65TT6.
SMRiQ65TT6. Positions 4-880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65TT6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEEYLMMRN NINMLGRFLG ETIQEAQGDD ILELIENIRV LSRNSRSGDD
60 70 80 90 100
KARAALLDTL STISADNIIP VARAFSQFLN LTNVAEQYQT MSRSHEDKVS
110 120 130 140 150
AERSTAALFA RLKEQHVSQE EIIKTVQKLL IEIVLTAHPT EVTRRSLMHK
160 170 180 190 200
QVEINKCLAQ LDHTDLTAEE QKNIEYKLLR LIAEAWHTNE IRTNRPTPLE
210 220 230 240 250
EAKWGFAVIE NSLWEGLPAF IRKLNDAAVE HLNYALPVDL TPVRFSSWMG
260 270 280 290 300
GDRDGNPFVT AKITREALQL ARWKAADLFL TDIQELCDEL SMTQCTAEFR
310 320 330 340 350
EKYGDHLEPY RVVVKDLRSK LKNTLDYYND ILAGRIPPFK QDEIISEDQQ
360 370 380 390 400
LWQPLYDCYQ SLTACGMRII ANGLLLDTLR RVRCFGVTLL RLDIRQESTR
410 420 430 440 450
HSDAIGEITR YIGLGDYSQW TEDDKQAFLI RELSSRRPLI PHNWTPSEHT
460 470 480 490 500
REILDTCKVI AKQPEGVISC YIISMARTAS DVLAVHLLLK EAGISYHLPV
510 520 530 540 550
VPLFETLDDL DASKEVMTQL FNVGWYRGVI KNRQMIMIGY SDSAKDAGMM
560 570 580 590 600
AASWAQYRAQ DALVKLCEQT GIELTLFHGR GGTVGRGGAP AHAALLSQPP
610 620 630 640 650
RSLKNGLRVT EQGEMIRFKL GLPAIAAESL DLYASAILEA NLLPPPEPKA
660 670 680 690 700
SWCRVMDELA VASCEIYRNV VRGDKDFVPY FRSATPEQEL AKLPLGSRPA
710 720 730 740 750
KRNPNGGVES LRAIPWIFAW MQNRLMLPAW LGAGASIRQA MESGKAAVIE
760 770 780 790 800
EMCNHWPFFN TRIGMLEMVF SKTDSWLSEY YDQRLVKKEL WYLGESLRKQ
810 820 830 840 850
LSEDIATVLR LSGKGDQLMS DLPWVAESIA LRNVYTDPLN LLQVELLRRL
860 870 880
RADPEHPNPD IEQALMITIT GIAAGMRNTG
Length:880
Mass (Da):99,613
Last modified:October 25, 2004 - v1
Checksum:iB67AA9DE11D8C59D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016827 Genomic DNA. Translation: AAU37624.1.
RefSeqiYP_088209.1. NC_006300.1.

Genome annotation databases

EnsemblBacteriaiAAU37624; AAU37624; MS1017.
GeneIDi3077157.
KEGGimsu:MS1017.
PATRICi22445399. VBIManSuc86752_0931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016827 Genomic DNA. Translation: AAU37624.1.
RefSeqiYP_088209.1. NC_006300.1.

3D structure databases

ProteinModelPortaliQ65TT6.
SMRiQ65TT6. Positions 4-880.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi221988.MS1017.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU37624; AAU37624; MS1017.
GeneIDi3077157.
KEGGimsu:MS1017.
PATRICi22445399. VBIManSuc86752_0931.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciBMAN221988:GHGM-1053-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
    Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
    Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MBEL55EImported.

Entry informationi

Entry nameiQ65TT6_MANSM
AccessioniPrimary (citable) accession number: Q65TT6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: February 4, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.