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Q65TC8

- TRUA_MANSM

UniProt

Q65TC8 - TRUA_MANSM

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Protein
tRNA pseudouridine synthase A
Gene
truA, MS1175
Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs By similarity.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511Nucleophile By similarity
Binding sitei109 – 1091Substrate By similarity

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. pseudouridine synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciBMAN221988:GHGM-1210-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase A (EC:5.4.99.12)
Alternative name(s):
tRNA pseudouridine(38-40) synthase
tRNA pseudouridylate synthase I
tRNA-uridine isomerase I
Gene namesi
Name:truA
Ordered Locus Names:MS1175
OrganismiMannheimia succiniciproducens (strain MBEL55E)
Taxonomic identifieri221988 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
ProteomesiUP000000607: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263tRNA pseudouridine synthase AUniRule annotation
PRO_0000057405Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi221988.MS1175.

Structurei

3D structure databases

ProteinModelPortaliQ65TC8.
SMRiQ65TC8. Positions 2-261.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0101.
HOGENOMiHOG000248672.
KOiK06173.
OrthoDBiEOG6Z9B4R.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65TC8-1 [UniParc]FASTAAdd to Basket

« Hide

MKIALGIEYN GKNYFGWQRQ EKVHSVQAEL EKALSFVANE KIEVFCAGRT    50
DSGVHGTGQV VHFETNAIRP EKAWAFGTNA NLPDDIAVRW AKEVPDDFHA 100
RFSATARRYR YVLYCNKLRS AILPYGITHT HLDLDEHKMQ EAGRFLLGEN 150
DFSSFRAAQC QSNTPWRNIH HLNVIRRGNF VIVDIKANAF VHHMVRNIVG 200
SLMEVGCGNQ PPEWIEWLLA QKNRKLAAPT AKAEGLYLVQ VTYPEHFELP 250
QMPLGPLFLA DEL 263
Length:263
Mass (Da):29,955
Last modified:April 26, 2005 - v2
Checksum:iC419C1B3B2F1D749
GO

Sequence cautioni

The sequence AAU37782.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016827 Genomic DNA. Translation: AAU37782.1. Different initiation.
RefSeqiYP_088367.1. NC_006300.1.

Genome annotation databases

EnsemblBacteriaiAAU37782; AAU37782; MS1175.
GeneIDi3076252.
KEGGimsu:MS1175.
PATRICi22445683. VBIManSuc86752_1073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016827 Genomic DNA. Translation: AAU37782.1 . Different initiation.
RefSeqi YP_088367.1. NC_006300.1.

3D structure databases

ProteinModelPortali Q65TC8.
SMRi Q65TC8. Positions 2-261.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 221988.MS1175.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU37782 ; AAU37782 ; MS1175 .
GeneIDi 3076252.
KEGGi msu:MS1175.
PATRICi 22445683. VBIManSuc86752_1073.

Phylogenomic databases

eggNOGi COG0101.
HOGENOMi HOG000248672.
KOi K06173.
OrthoDBi EOG6Z9B4R.

Enzyme and pathway databases

BioCyci BMAN221988:GHGM-1210-MONOMER.

Family and domain databases

Gene3Di 3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPi MF_00171. TruA.
InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view ]
PANTHERi PTHR11142. PTHR11142. 1 hit.
Pfami PF01416. PseudoU_synth_1. 2 hits.
[Graphical view ]
PIRSFi PIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMi SSF55120. SSF55120. 1 hit.
TIGRFAMsi TIGR00071. hisT_truA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
    Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
    Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MBEL55E.

Entry informationi

Entry nameiTRUA_MANSM
AccessioniPrimary (citable) accession number: Q65TC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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