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Q65TC8

- TRUA_MANSM

UniProt

Q65TC8 - TRUA_MANSM

Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 2 (26 Apr 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

    Catalytic activityi

    tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei51 – 511NucleophileUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation

    GO - Molecular functioni

    1. pseudouridine synthase activity Source: UniProtKB-HAMAP
    2. RNA binding Source: InterPro

    GO - Biological processi

    1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    tRNA processing

    Enzyme and pathway databases

    BioCyciBMAN221988:GHGM-1210-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
    Alternative name(s):
    tRNA pseudouridine(38-40) synthaseUniRule annotation
    tRNA pseudouridylate synthase IUniRule annotation
    tRNA-uridine isomerase IUniRule annotation
    Gene namesi
    Name:truAUniRule annotation
    Ordered Locus Names:MS1175
    OrganismiMannheimia succiniciproducens (strain MBEL55E)
    Taxonomic identifieri221988 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
    ProteomesiUP000000607: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263tRNA pseudouridine synthase APRO_0000057405Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi221988.MS1175.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65TC8.
    SMRiQ65TC8. Positions 2-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0101.
    HOGENOMiHOG000248672.
    KOiK06173.
    OrthoDBiEOG6Z9B4R.

    Family and domain databases

    Gene3Di3.30.70.580. 1 hit.
    3.30.70.660. 1 hit.
    HAMAPiMF_00171. TruA.
    InterProiIPR020103. PsdUridine_synth_cat_dom.
    IPR001406. PsdUridine_synth_TruA.
    IPR020097. PsdUridine_synth_TruA_a/b_dom.
    IPR020095. PsdUridine_synth_TruA_C.
    IPR020094. PsdUridine_synth_TruA_N.
    [Graphical view]
    PANTHERiPTHR11142. PTHR11142. 1 hit.
    PfamiPF01416. PseudoU_synth_1. 2 hits.
    [Graphical view]
    PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
    SUPFAMiSSF55120. SSF55120. 1 hit.
    TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q65TC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIALGIEYN GKNYFGWQRQ EKVHSVQAEL EKALSFVANE KIEVFCAGRT    50
    DSGVHGTGQV VHFETNAIRP EKAWAFGTNA NLPDDIAVRW AKEVPDDFHA 100
    RFSATARRYR YVLYCNKLRS AILPYGITHT HLDLDEHKMQ EAGRFLLGEN 150
    DFSSFRAAQC QSNTPWRNIH HLNVIRRGNF VIVDIKANAF VHHMVRNIVG 200
    SLMEVGCGNQ PPEWIEWLLA QKNRKLAAPT AKAEGLYLVQ VTYPEHFELP 250
    QMPLGPLFLA DEL 263
    Length:263
    Mass (Da):29,955
    Last modified:April 26, 2005 - v2
    Checksum:iC419C1B3B2F1D749
    GO

    Sequence cautioni

    The sequence AAU37782.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016827 Genomic DNA. Translation: AAU37782.1. Different initiation.
    RefSeqiYP_088367.1. NC_006300.1.

    Genome annotation databases

    EnsemblBacteriaiAAU37782; AAU37782; MS1175.
    GeneIDi3076252.
    KEGGimsu:MS1175.
    PATRICi22445683. VBIManSuc86752_1073.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016827 Genomic DNA. Translation: AAU37782.1 . Different initiation.
    RefSeqi YP_088367.1. NC_006300.1.

    3D structure databases

    ProteinModelPortali Q65TC8.
    SMRi Q65TC8. Positions 2-261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 221988.MS1175.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU37782 ; AAU37782 ; MS1175 .
    GeneIDi 3076252.
    KEGGi msu:MS1175.
    PATRICi 22445683. VBIManSuc86752_1073.

    Phylogenomic databases

    eggNOGi COG0101.
    HOGENOMi HOG000248672.
    KOi K06173.
    OrthoDBi EOG6Z9B4R.

    Enzyme and pathway databases

    BioCyci BMAN221988:GHGM-1210-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.580. 1 hit.
    3.30.70.660. 1 hit.
    HAMAPi MF_00171. TruA.
    InterProi IPR020103. PsdUridine_synth_cat_dom.
    IPR001406. PsdUridine_synth_TruA.
    IPR020097. PsdUridine_synth_TruA_a/b_dom.
    IPR020095. PsdUridine_synth_TruA_C.
    IPR020094. PsdUridine_synth_TruA_N.
    [Graphical view ]
    PANTHERi PTHR11142. PTHR11142. 1 hit.
    Pfami PF01416. PseudoU_synth_1. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF001430. tRNA_psdUrid_synth. 1 hit.
    SUPFAMi SSF55120. SSF55120. 1 hit.
    TIGRFAMsi TIGR00071. hisT_truA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
      Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
      Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MBEL55E.

    Entry informationi

    Entry nameiTRUA_MANSM
    AccessioniPrimary (citable) accession number: Q65TC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3