Q65SS8 (NRDR_MANSM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcriptional repressor NrdR

Gene names

Name:	nrdR
Ordered Locus Names:	MS1375

Organism

Mannheimia succiniciproducens (strain MBEL55E) [Complete proteome] [HAMAP]

Taxonomic identifier

221988 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Basfia › Mannheimia succiniciproducens

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes By similarity. HAMAP-Rule MF_00440
Cofactor	Binds 1 zinc ion By similarity.
Sequence similarities	Belongs to the NrdR family. Contains 1 ATP-cone domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Domain	Zinc-finger
Ligand	ATP-binding DNA-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 149	149	Transcriptional repressor NrdR HAMAP-Rule MF_00440		PRO_0000182316
Regions
	Domain	49 – 139	91	ATP-cone
	Zinc finger	3 – 34	32	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65SS8 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 53A74AB7349E1138	FASTA	149	17,326
	10 20 30 40 50 60 MHCPFCSTEE TKVIDSRLVS DGYQVRRRRE CTKCHERFTT FETAELVVPK IIKNNGMREP 70 80 90 100 110 120 FNEDKLRRGI QHALEKRPVS ADDVEKAISH ITHQLRATGE REVPSKLVGS LVMEELKKLD 130 140 KVAYIRFASV YLSFENINEF SNEIEKLKD

References

[1]

"The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens." Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J. Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MBEL55E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016827 Genomic DNA. Translation: AAU37982.1.
RefSeq	YP_088567.1. NC_006300.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	221988.MS1375.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU37982; AAU37982; MS1375.
GeneID	3076702.
KEGG	msu:MS1375.
PATRIC	22446061. VBIManSuc86752_1255.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1327.
HOGENOM	HOG000097653.
KO	K07738.
OMA	VCHERFT.
ProtClustDB	PRK00464.
Enzyme and pathway databases
BioCyc	BMAN221988:GHGM-1370-MONOMER.
Family and domain databases
HAMAP	MF_00440. NrdR.
InterPro	IPR005144. ATP-cone. IPR003796. RNR_NrdR-like. [Graphical view]
Pfam	PF03477. ATP-cone. 1 hit. [Graphical view]
TIGRFAMs	TIGR00244. TIGR00244. 1 hit.
PROSITE	PS51161. ATP_CONE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NRDR_MANSM

Accession

Primary (citable) accession number: Q65SS8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	October 25, 2004
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program