SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q65SH4

- ASSY_MANSM

UniProt

Q65SH4 - ASSY_MANSM

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Argininosuccinate synthase

Gene
argG, MS1479
Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441ATP By similarity
Binding sitei100 – 1001Citrulline By similarity
Binding sitei130 – 1301ATP; via amide nitrogen By similarity
Binding sitei132 – 1321Aspartate By similarity
Binding sitei132 – 1321ATP By similarity
Binding sitei136 – 1361Aspartate By similarity
Binding sitei136 – 1361Citrulline By similarity
Binding sitei137 – 1371Aspartate By similarity
Binding sitei137 – 1371ATP By similarity
Binding sitei140 – 1401Citrulline By similarity
Binding sitei193 – 1931Citrulline By similarity
Binding sitei195 – 1951ATP By similarity
Binding sitei202 – 2021Citrulline By similarity
Binding sitei204 – 2041Citrulline By similarity
Binding sitei281 – 2811Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBMAN221988:GHGM-1522-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:MS1479
OrganismiMannheimia succiniciproducens (strain MBEL55E)
Taxonomic identifieri221988 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
ProteomesiUP000000607: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Argininosuccinate synthaseUniRule annotationPRO_1000025431Add
BLAST

Proteomic databases

PRIDEiQ65SH4.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi221988.MS1479.

Structurei

3D structure databases

ProteinModelPortaliQ65SH4.
SMRiQ65SH4. Positions 4-441.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230094.
KOiK01940.
OMAiPWNEPTK.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di1.10.287.400. 1 hit.
3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00581. Arg_succ_synth_type2.
InterProiIPR023437. Arg_succ_synth_type2_subfam.
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65SH4-1 [UniParc]FASTAAdd to Basket

« Hide

MSNTILQNLP LGQKVGIAFS GGLDTSAALL WMRQKGAVPY AYTANLGQPD    50
EDDYNAIPKK AMAYGAENAR LIDCRKQLAQ EGIAAIQCGA FHISTGGVTY 100
FNTTPLGRAV TGTMLVAAMK EDDVNIWGDG STFKGNDIER FYRYGLLTNP 150
NLKIYKPWLD DQFIDELGGR FEMSQFLIAN GFDYKMSVEK AYSTDSNMLG 200
ATHEAKDLED LSTGIKIVKP IMGVAFWDES VEIKPEVVTV RFEEGVPVEL 250
NGKRFDDVVE LFMEANRIGG RHGLGMSDQI ENRIIEAKSR GIYEAPGMAL 300
FHIAYERLVT GIHNEDTIEQ YRINGLRLGR LLYQGRWFDP QALMLRESSQ 350
RWVAKAITGE VKLELRRGND YSILDTVSPN LTYEAERLSM EKVEDAPFDP 400
IDRIGQLTMR NLDVTDTRNK LGIYSEAGLL TAGKDAVVPQ LGSK 444
Length:444
Mass (Da):49,466
Last modified:October 25, 2004 - v1
Checksum:iF40DF4E2D0BA31BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016827 Genomic DNA. Translation: AAU38086.1.
RefSeqiYP_088671.1. NC_006300.1.

Genome annotation databases

EnsemblBacteriaiAAU38086; AAU38086; MS1479.
GeneIDi3076838.
KEGGimsu:MS1479.
PATRICi22446247. VBIManSuc86752_1346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016827 Genomic DNA. Translation: AAU38086.1 .
RefSeqi YP_088671.1. NC_006300.1.

3D structure databases

ProteinModelPortali Q65SH4.
SMRi Q65SH4. Positions 4-441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 221988.MS1479.

Proteomic databases

PRIDEi Q65SH4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU38086 ; AAU38086 ; MS1479 .
GeneIDi 3076838.
KEGGi msu:MS1479.
PATRICi 22446247. VBIManSuc86752_1346.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230094.
KOi K01940.
OMAi PWNEPTK.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci BMAN221988:GHGM-1522-MONOMER.

Family and domain databases

Gene3Di 1.10.287.400. 1 hit.
3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00581. Arg_succ_synth_type2.
InterProi IPR023437. Arg_succ_synth_type2_subfam.
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
    Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
    Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MBEL55E.

Entry informationi

Entry nameiASSY_MANSM
AccessioniPrimary (citable) accession number: Q65SH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi