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Q65SH4

- ASSY_MANSM

UniProt

Q65SH4 - ASSY_MANSM

Protein

Argininosuccinate synthase

Gene

argG

Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441ATPUniRule annotation
    Binding sitei100 – 1001CitrullineUniRule annotation
    Binding sitei130 – 1301ATP; via amide nitrogenUniRule annotation
    Binding sitei132 – 1321AspartateUniRule annotation
    Binding sitei132 – 1321ATPUniRule annotation
    Binding sitei136 – 1361AspartateUniRule annotation
    Binding sitei136 – 1361CitrullineUniRule annotation
    Binding sitei137 – 1371AspartateUniRule annotation
    Binding sitei137 – 1371ATPUniRule annotation
    Binding sitei140 – 1401CitrullineUniRule annotation
    Binding sitei193 – 1931CitrullineUniRule annotation
    Binding sitei195 – 1951ATPUniRule annotation
    Binding sitei202 – 2021CitrullineUniRule annotation
    Binding sitei204 – 2041CitrullineUniRule annotation
    Binding sitei281 – 2811CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 269ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBMAN221988:GHGM-1522-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:MS1479
    OrganismiMannheimia succiniciproducens (strain MBEL55E)
    Taxonomic identifieri221988 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
    ProteomesiUP000000607: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 444444Argininosuccinate synthasePRO_1000025431Add
    BLAST

    Proteomic databases

    PRIDEiQ65SH4.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi221988.MS1479.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65SH4.
    SMRiQ65SH4. Positions 4-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230094.
    KOiK01940.
    OMAiPWNEPTK.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00581. Arg_succ_synth_type2.
    InterProiIPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q65SH4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNTILQNLP LGQKVGIAFS GGLDTSAALL WMRQKGAVPY AYTANLGQPD    50
    EDDYNAIPKK AMAYGAENAR LIDCRKQLAQ EGIAAIQCGA FHISTGGVTY 100
    FNTTPLGRAV TGTMLVAAMK EDDVNIWGDG STFKGNDIER FYRYGLLTNP 150
    NLKIYKPWLD DQFIDELGGR FEMSQFLIAN GFDYKMSVEK AYSTDSNMLG 200
    ATHEAKDLED LSTGIKIVKP IMGVAFWDES VEIKPEVVTV RFEEGVPVEL 250
    NGKRFDDVVE LFMEANRIGG RHGLGMSDQI ENRIIEAKSR GIYEAPGMAL 300
    FHIAYERLVT GIHNEDTIEQ YRINGLRLGR LLYQGRWFDP QALMLRESSQ 350
    RWVAKAITGE VKLELRRGND YSILDTVSPN LTYEAERLSM EKVEDAPFDP 400
    IDRIGQLTMR NLDVTDTRNK LGIYSEAGLL TAGKDAVVPQ LGSK 444
    Length:444
    Mass (Da):49,466
    Last modified:October 25, 2004 - v1
    Checksum:iF40DF4E2D0BA31BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016827 Genomic DNA. Translation: AAU38086.1.
    RefSeqiYP_088671.1. NC_006300.1.

    Genome annotation databases

    EnsemblBacteriaiAAU38086; AAU38086; MS1479.
    GeneIDi3076838.
    KEGGimsu:MS1479.
    PATRICi22446247. VBIManSuc86752_1346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016827 Genomic DNA. Translation: AAU38086.1 .
    RefSeqi YP_088671.1. NC_006300.1.

    3D structure databases

    ProteinModelPortali Q65SH4.
    SMRi Q65SH4. Positions 4-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 221988.MS1479.

    Proteomic databases

    PRIDEi Q65SH4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU38086 ; AAU38086 ; MS1479 .
    GeneIDi 3076838.
    KEGGi msu:MS1479.
    PATRICi 22446247. VBIManSuc86752_1346.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230094.
    KOi K01940.
    OMAi PWNEPTK.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci BMAN221988:GHGM-1522-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00581. Arg_succ_synth_type2.
    InterProi IPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
      Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
      Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MBEL55E.

    Entry informationi

    Entry nameiASSY_MANSM
    AccessioniPrimary (citable) accession number: Q65SH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3