Q65SD7 (MUTL_MANSM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein mutL

Gene names

Name:	mutL
Ordered Locus Names:	MS1516

Organism

Mannheimia succiniciproducens (strain MBEL55E) [Complete proteome] [HAMAP]

Taxonomic identifier

221988 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Basfia

Protein attributes

Sequence length	631 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. HAMAP MF_00149
Sequence similarities	Belongs to the DNA mismatch repair mutL/hexB family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mismatch repair Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 631	631	DNA mismatch repair protein mutL HAMAP MF_00149		PRO_1000010041

Sequences

	Sequence		Length	Mass (Da)
	Q65SD7 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: D009C3A26B8235A8	FASTA	631	70,906
	10 20 30 40 50 60 MPIHILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAS RIQIDIENGG ATLIRIRDNG 70 80 90 100 110 120 LGIAKEDLSL ALARHATSKI SCLDDLEAIL SLGFRGEALA SISSVSRLTL TSRTAEQKEA 130 140 150 160 170 180 WQVYAQGRDM ETTIKPASHP VGTTVEVANL FFNTPARRKF LRTEKTEFAH IDEVVRRIAL 190 200 210 220 230 240 AKPQIAFTLT HNGKILRQYK SAVEIEQKLK RVSAICGEDF VQNALQIDWK HDNLHLSGWV 250 260 270 280 290 300 AVPNFHRPQN DLSYSYVNGR MIRDKVINHA IRQAYGDYLT NEQYPAFVLY LDLDPNEVDV 310 320 330 340 350 360 NVHPTKHEVR FHQARLIHDF ICQGVGNALQ SEQADFARYD TPASADEIQE PAANWHSSLI 370 380 390 400 410 420 KPNRSAAGHN IFESASDKNI SGANTYSHGS AKINRFSTKF AENIPHFSTK SVSKTEQKLY 430 440 450 460 470 480 GNLLTTPAEA KKNTAINAES ENSFEKNVST PQQSTQLSGQ FLHSLALVKN QALLLQQGQD 490 500 510 520 530 540 FYLLPLAKLQ KLKFELTLQQ PDIAQQPLLI PILFRLNERQ LAQWQKQKNF FLQSGFEFDE 550 560 570 580 590 600 NPAQHRITLN KVPSCLRQQN LQGCVIRLLE ENHEKISDFL TALCNQLQLN EIHVLADALT 610 620 630 LLTEVELLLK TQNKIQLAQL LISVDFTQYL Q

References

[1]

"The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens." Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J. Nat. Biotechnol. 22:1275-1281(2004) [PubMed: 15378067] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MBEL55E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016827 Genomic DNA. Translation: AAU38123.1.
RefSeq	YP_088708.1. NC_006300.1.
3D structure databases
HSSP	HSSP built from PDB template 1BKN based on UniProtKB P23367.
ProteinModelPortal	Q65SD7.
SMR	Q65SD7. Positions 1-330.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65SD7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3076978.
GenomeReviews	Gene locus MS1516 in contig AE016827_GR.
KEGG	msu:MS1516.
NMPDR	fig|221988.1.peg.1423.
PATRIC	22446319. VBIManSuc86752_1380.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0323.
HOGENOM	HBG520262.
OMA	EVANLFF.
PhylomeDB	Q65SD7.
ProtClustDB	PRK00095.
Enzyme and pathway databases
BioCyc	MSUC221988:MS1516-MONOMER.
Family and domain databases
HAMAP	MF_00149. DNA_mis_repair. [Tree]
InterPro	IPR003594. ATPase-like_ATP-bd. IPR002099. DNA_mismatch_repair. IPR013507. DNA_mismatch_repair_C. IPR014762. DNA_mismatch_repair_CS. IPR020667. DNA_mismatch_repair_MutL. IPR014763. DNA_mismatch_repair_N. IPR014790. MutL_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K03572.
PANTHER	PTHR10073. DNA_mis_repair. 1 hit.
Pfam	PF01119. DNA_mis_repair. 1 hit. PF02518. HATPase_c. 1 hit. PF08676. MutL_C. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. SM00853. MutL_C. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00585. Mutl. 1 hit.
PROSITE	PS00058. DNA_MISMATCH_REPAIR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTL_MANSM

Accession

Primary (citable) accession number: Q65SD7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program