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Q65SC6

- NAGK_MANSM

UniProt

Q65SC6 - NAGK_MANSM

Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

    Catalytic activityi

    ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi157 – 1571ZincUniRule annotation
    Metal bindingi178 – 1781ZincUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation
    Metal bindingi185 – 1851ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 118ATPUniRule annotation
    Nucleotide bindingi133 – 1408ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
    2. peptidoglycan turnover Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciBMAN221988:GHGM-1572-MONOMER.
    UniPathwayiUPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
    Alternative name(s):
    GlcNAc kinaseUniRule annotation
    Gene namesi
    Name:nagKUniRule annotation
    Ordered Locus Names:MS1527
    OrganismiMannheimia succiniciproducens (strain MBEL55E)
    Taxonomic identifieri221988 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
    ProteomesiUP000000607: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304N-acetyl-D-glucosamine kinasePRO_0000270108Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi221988.MS1527.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65SC6.
    SMRiQ65SC6. Positions 1-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1940.
    HOGENOMiHOG000150087.
    KOiK00884.
    OrthoDBiEOG61P6P0.

    Family and domain databases

    HAMAPiMF_01271. GlcNAc_kinase.
    InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view]
    PfamiPF00480. ROK. 1 hit.
    [Graphical view]
    PROSITEiPS01125. ROK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q65SC6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLYGFDIGGT KIELAVFNDK LERQYTERVE TPKDSYEQWL DVIVNLVEKA    50
    DQKFACKGSV GLGLPGFVNH ETGIAEITNI RVADNKPIIK DLSERLGREV 100
    RAENDANCFA LSEAWDEENQ QYPFVLGLIL GTGFGGGLIF NGKVHSGQIG 150
    MAGELGHLQL NYHALKLLGW DKAPIYDCGC GNRACLDTYL SGRGFEMLYR 200
    DLKGEALSAK EIIERFYAAD KTAVDFVGLF IELCAISLGN IITALDPHVI 250
    VLGGGLSNFD YLYEALPKAL PKHLMRSAKV PVIKKAKYGD SGGVRGAAAL 300
    FLTK 304
    Length:304
    Mass (Da):33,284
    Last modified:January 9, 2007 - v2
    Checksum:i51503279D504A2B5
    GO

    Sequence cautioni

    The sequence AAU38134.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016827 Genomic DNA. Translation: AAU38134.1. Different initiation.
    RefSeqiYP_088719.2. NC_006300.1.

    Genome annotation databases

    EnsemblBacteriaiAAU38134; AAU38134; MS1527.
    GeneIDi3077056.
    KEGGimsu:MS1527.
    PATRICi22446341. VBIManSuc86752_1391.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016827 Genomic DNA. Translation: AAU38134.1 . Different initiation.
    RefSeqi YP_088719.2. NC_006300.1.

    3D structure databases

    ProteinModelPortali Q65SC6.
    SMRi Q65SC6. Positions 1-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 221988.MS1527.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU38134 ; AAU38134 ; MS1527 .
    GeneIDi 3077056.
    KEGGi msu:MS1527.
    PATRICi 22446341. VBIManSuc86752_1391.

    Phylogenomic databases

    eggNOGi COG1940.
    HOGENOMi HOG000150087.
    KOi K00884.
    OrthoDBi EOG61P6P0.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .
    BioCyci BMAN221988:GHGM-1572-MONOMER.

    Family and domain databases

    HAMAPi MF_01271. GlcNAc_kinase.
    InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view ]
    Pfami PF00480. ROK. 1 hit.
    [Graphical view ]
    PROSITEi PS01125. ROK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
      Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
      Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MBEL55E.

    Entry informationi

    Entry nameiNAGK_MANSM
    AccessioniPrimary (citable) accession number: Q65SC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3