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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBMAN221988:GHGM-1603-MONOMER.
UniPathwayiUPA00392.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:MS1558
OrganismiMannheimia succiniciproducens (strain MBEL55E)
Taxonomic identifieri221988 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
Proteomesi
  • UP000000607 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363S-adenosylmethionine:tRNA ribosyltransferase-isomerasePRO_0000231348Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi221988.MS1558.

Structurei

3D structure databases

ProteinModelPortaliQ65S95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2N. Bacteria.
COG0809. LUCA.
HOGENOMiHOG000004401.
KOiK07568.
OMAiYGDAMFL.
OrthoDBiEOG6X6RBB.

Family and domain databases

HAMAPiMF_00113. QueA.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 1 hit.
TIGRFAMsiTIGR00113. queA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65S95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLSDFYFDL PDELIARYPK PERSSSRLLR LSGENGDISH HTFSDVYDLI
60 70 80 90 100
NEGDLLIFNN TRVIPARMYG RKASGGKIEV LIERVLTESR FLAHVRSSKA
110 120 130 140 150
PKAGTELILG EDKLGEGKGV KAVMIGRQDA LFELEITEKS TALLDILQKI
160 170 180 190 200
GHMPLPPYID RPDEDADQER YQTVYSKIPG AVAAPTAGLH FDEELLAKLK
210 220 230 240 250
AKGVNFAFVT LHVGAGTFQP VRVNNIEEHH MHAEYVEVPQ QVVDAIVATK
260 270 280 290 300
AAGKRVIAVG TTSVRSVESA ALAAQEKGFA QIIEPFFADT SIFIYPGKQF
310 320 330 340 350
RVVDCLITNF HLPESTLIML VSAFAGYKNT MNAYKSAVEN RYRFFSYGDA
360
MFITKNNHVK GLD
Length:363
Mass (Da):40,321
Last modified:October 25, 2004 - v1
Checksum:i695F05DFBC71793E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016827 Genomic DNA. Translation: AAU38165.1.
RefSeqiWP_011200730.1. NC_006300.1.

Genome annotation databases

EnsemblBacteriaiAAU38165; AAU38165; MS1558.
KEGGimsu:MS1558.
PATRICi22446399. VBIManSuc86752_1419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016827 Genomic DNA. Translation: AAU38165.1.
RefSeqiWP_011200730.1. NC_006300.1.

3D structure databases

ProteinModelPortaliQ65S95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi221988.MS1558.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU38165; AAU38165; MS1558.
KEGGimsu:MS1558.
PATRICi22446399. VBIManSuc86752_1419.

Phylogenomic databases

eggNOGiENOG4105E2N. Bacteria.
COG0809. LUCA.
HOGENOMiHOG000004401.
KOiK07568.
OMAiYGDAMFL.
OrthoDBiEOG6X6RBB.

Enzyme and pathway databases

UniPathwayiUPA00392.
BioCyciBMAN221988:GHGM-1603-MONOMER.

Family and domain databases

HAMAPiMF_00113. QueA.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 1 hit.
TIGRFAMsiTIGR00113. queA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
    Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
    Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MBEL55E.

Entry informationi

Entry nameiQUEA_MANSM
AccessioniPrimary (citable) accession number: Q65S95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 25, 2004
Last modified: November 11, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.