Reviewed, UniProtKB/Swiss-Prot Q65S79 (HIS81_MANSM)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Ordered Locus Names:	MS1574

Organism

Mannheimia succiniciproducens (strain MBEL55E) [Complete proteome] [HAMAP]

Taxonomic identifier

221988 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Mannheimia

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Inferred from electronic annotation. Source: InterPro histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000153388
Amino acid modifications
	Modified residue	226	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65S79-1 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: 62E34E766C0B45C5	FASTA	366	40,606
	10 20 30 40 50 60 MTFLQQANTG VQALSPYQAG KPIEELEREL GISNIIKLAS NENPFGFPES AKKAIQNQLD 70 80 90 100 110 120 NLTRYPDSNG FSLKAAIAEK FNLQPEQITL GNGSNDLIEL IAHTFATEGD EIIFSQYAFI 130 140 150 160 170 180 VYPLITKAIN AKAREIPAKN WGHDLEAFLA AINEKTKLIF IANPNNPTGN FLTEAEIDSF 190 200 210 220 230 240 LAKVPPHIVV ALDEAYTEFT AKEERVNSLA LLKKYPNLVV SRSLSKAYGL AGLRIGFAVS 250 260 270 280 290 300 NPEIAGLFNR VRQPFNVNSL ALAAAEAVLN DDDFVEKAAE NNRRELKRYE EFCQKYGLQY 310 320 330 340 350 360 IPSKGNFITI DFQQPAAPVY DALLHEGVIV RPIAGYGMPN HLRISIGLPE ENQRLFDALI KILNLK

References

[1]

"The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens." Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J. Nat. Biotechnol. 22:1275-1281(2004) [PubMed: 15378067] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016827 Genomic DNA. Translation: AAU38181.1. Different initiation.
RefSeq	YP_088766.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q65S79.
Genome annotation databases
GeneID	3077090.
GenomeReviews	Gene locus MS1574 in contig AE016827_GR.
KEGG	msu:MS1574.
NMPDR	fig|221988.1.peg.1479.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q65S79.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001176. ACC_synthase. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_MANSM

Accession

Primary (citable) accession number: Q65S79

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	January 10, 2006
Last modified:	September 22, 2009
This is version 28 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)