Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q65RJ7 (PUR4_MANSM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase

Short name=FGAM synthase
Short name=FGAMS
EC=6.3.5.3
Alternative name(s):
Formylglycinamide ribotide amidotransferase
Short name=FGARAT
Formylglycinamide ribotide synthetase
Gene names
Name:purL
Ordered Locus Names:MS1806
OrganismMannheimia succiniciproducens (strain MBEL55E) [Complete proteome] [HAMAP]
Taxonomic identifier221988 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia

Protein attributes

Sequence length1297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00419

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00419

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

In the N-terminal section; belongs to the FGAMS family.

Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   DomainGlutamine amidotransferase
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

glutamine metabolic process

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: HAMAP

phosphoribosylformylglycinamidine synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12971297Phosphoribosylformylglycinamidine synthase HAMAP-Rule MF_00419
PRO_0000264579

Regions

Domain1044 – 1297254Glutamine amidotransferase type-1
Nucleotide binding307 – 31812ATP Potential

Sites

Active site11371Nucleophile By similarity
Active site12621 By similarity
Active site12641 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q65RJ7 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 171374406217BEB4

FASTA1,297142,440
        10         20         30         40         50         60 
MFQIFRGSPA LSEFRLNQLS ARFQKADLPV KSCYAEYLHF ADLSAGLSAE ETDELEQLLH 

        70         80         90        100        110        120 
YGPTLAQHES KGECFVVIPR VGTISSWSSK ATDIAHNCGL DKVVRLERGI AYYFEFERTL 

       130        140        150        160        170        180 
SAEQQQRLVS HIHDRMMETV VRAPEQAAVL FDSQDPKPFT TVDILNGGRK ALEIANVELG 

       190        200        210        220        230        240 
LALASDEMDY LVENFTALGR NPNDIELYMF AQANSEHCRH KIFNADWVID GEKQEKSLFK 

       250        260        270        280        290        300 
MIKNTFEKTP DHVLSAYKDN AAVMEGSKVG RFFADQDGQY RYHNEDAHIL MKVETHNHPT 

       310        320        330        340        350        360 
AISPFPGAAT GSGGEIRDEG ATGRGAKPKA GLVGFSVSNL VIPGFEQPWE NELSKPSRIS 

       370        380        390        400        410        420 
SALDIMIEGP LGGAAFNNEF GRPALLGYFR TYEEKVNSFA GEEVRGYHKP IMLAGGIGNI 

       430        440        450        460        470        480 
RAEHVQKGEI PVGAKLIVLG GPAMNIGLGG GAASSMTSGK SKEDLDFASV QRDNPEMERR 

       490        500        510        520        530        540 
CQEVIDRCWQ MGEGNPIAFI HDVGAGGLSN AMPELVHDGG RGGKFELRNI LCDERGMSPL 

       550        560        570        580        590        600 
EIWCNESQER YVLAVAPENL AVFEELCQRE RAPYAIIGEA TEEEHLTLHD NHFDNNPIDL 

       610        620        630        640        650        660 
PMSLLLGKTP KMTRDVKSTQ VNNSPVDQTN IELKEAFHRV LRLPVVAEKT FLITIGDRTV 

       670        680        690        700        710        720 
TGMVARDQMV GPWQIPVSDV AVTTAALDTY HGEAMSIGER APVALLDFAA SARLAVAESI 

       730        740        750        760        770        780 
TNIAATNIGD IKRIKLSANW MSAAGHEGED AGLYEAVKAV GEELCPALGL TVPVGKDSMS 

       790        800        810        820        830        840 
MKTTWSENGE QKTVTAPLSL VISAFARVED VRKTVTPQLR TDKGETALLL IDLGEGKNRL 

       850        860        870        880        890        900 
GATALAQVYK QLGDKPADVV NVELLKGFYN AMQTLVQQGK LLAYHDRSDG GLIVTLAEMA 

       910        920        930        940        950        960 
FAGNCGIRAE ISALGDNDLG ILFSEELGAV IQVRESDLAA VREVLTQHGL IHLTKDLGLV 

       970        980        990       1000       1010       1020 
TEYDEFEIKR GTKVVLSEKR SELRGIWAEL THQMQRLRDN PECADQEFAA KKDPANQGFS 

      1030       1040       1050       1060       1070       1080 
AHLTYDINED VAAPYIATGK KPRIAVLREQ GVNSHVEMGA AFDRAGFEAI DVHMSDLHTA 

      1090       1100       1110       1120       1130       1140 
RQNLKDFNAL VACGGFSYGD VLGAGGGWAK SVLFNTALRD QFQAFFERED TLALGVCNGC 

      1150       1160       1170       1180       1190       1200 
QMISTLADII PGTENWPRFV RNTSERFEAR AALVRINESN SVWFQGMAGS HMPIAVSHGE 

      1210       1220       1230       1240       1250       1260 
GRVEFKNDSQ LQGLRDQGLI IAQYVDNNIR PTEVYPANPN GSVDGITALS NTNGRVAIMM 

      1270       1280       1290 
PHPERVFRTV SNSWHPEDWS EDGAWMRLFR NARVFFK 

« Hide

References

[1]"The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MBEL55E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016827 Genomic DNA. Translation: AAU38413.1.
RefSeqYP_088998.1. NC_006300.1.

3D structure databases

HSSPHSSP built from PDB template 1T3T based on UniProtKB P74881.
ProteinModelPortalQ65RJ7.
ModBaseSearch...

Protein-protein interaction databases

STRING221988.MS1806.

Proteomic databases

PRIDEQ65RJ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU38413; AAU38413; MS1806.
GeneID3075302.
KEGGmsu:MS1806.
PATRIC22446883. VBIManSuc86752_1650.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0046.
HOGENOMHOG000261359.
KOK01952.
OMATVKAVGM.
ProtClustDBPRK05297.

Enzyme and pathway databases

BioCycBMAN221988:GHGM-1797-MONOMER.
UniPathwayUPA00074; UER00128.

Family and domain databases

HAMAPMF_00419. PurL_1.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR017926. GATASE_1.
IPR010073. PRibForGlyAmidine_synth.
IPR022940. PRibForGlyAmidine_synth_bac.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 2 hits.
SSF55326. PurM_N-like. 2 hits.
TIGRFAMsTIGR01735. FGAM_synt. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR4_MANSM
AccessionPrimary (citable) accession number: Q65RJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 25, 2004
Last modified: May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families