Reviewed,
UniProtKB/Swiss-Prot Q65RJ7 (PUR4_MANSM)
Last modified
November 3, 2009.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phosphoribosylformylglycinamidine synthase Short name=FGAM synthase Short name=FGAMS EC=6.3.5.3 Alternative name(s): Formylglycinamide ribotide amidotransferase Short name=FGARAT Formylglycinamide ribotide synthetase | ||||
| Gene names |
| ||||
| Organism | Mannheimia succiniciproducens (strain MBEL55E) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 221988 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Mannheimia |
Protein attributes
| Sequence length | 1297 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP MF_00419 |
| Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP MF_00419 |
| Subunit structure | Monomer. HAMAP MF_00419 |
| Subcellular location | |
| Sequence similarities | In the N-terminal section; belongs to the FGAMS family. Contains 1 glutamine amidotransferase type-1 domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Cellular component | Cytoplasm |
| Domain | Glutamine amidotransferase |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | 'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro glutamine metabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP phosphoribosylformylglycinamidine synthase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1297 | 1297 | Phosphoribosylformylglycinamidine synthase HAMAP MF_00419 | PRO_0000264579 | |||||
Regions | |||||||||
| Domain | 1044 – 1297 | 254 | Glutamine amidotransferase type-1 | ||||||
| Nucleotide binding | 307 – 318 | 12 | ATP Potential | ||||||
Sites | |||||||||
| Active site | 1137 | 1 | Nucleophile By similarity | ||||||
| Active site | 1262 | 1 | By similarity | ||||||
| Active site | 1264 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens." Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J. Nat. Biotechnol. 22:1275-1281(2004) [PubMed: 15378067] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AE016827 Genomic DNA. Translation: AAU38413.1. | |
| RefSeq | YP_088998.1. |
3D structure databases | |
| SMR | Q65RJ7. Positions 1-1293. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q65RJ7. |
Genome annotation databases | |
| GeneID | 3075302. |
| GenomeReviews | Gene locus MS1806 in contig AE016827_GR. |
| KEGG | msu:MS1806. |
| NMPDR | fig|221988.1.peg.1696. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q65RJ7. |
| OMA | ERGIAYY. |
Family and domain databases | |
| HAMAP | MF_00419. [Tree] |
| InterPro | IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR017926. GATASE_1. IPR010073. PRibForGlyAmidine_synth. [Graphical view] |
| Pfam | PF00586. AIRS. 1 hit. PF02769. AIRS_C. 2 hits. [Graphical view] |
| TIGRFAMs | TIGR01735. FGAM_synt. 1 hit. |
| PROSITE | PS51273. GATASE_TYPE_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PUR4_MANSM | ||||||||
| Accession | Primary (citable) accession number: Q65RJ7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


