Q65RG8 (CDD_MANSM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidine deaminase
EC=3.5.4.5

Alternative name(s):
Cytidine aminohydrolase
Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	MS1835

Organism

Mannheimia succiniciproducens (strain MBEL55E) [Complete proteome] [HAMAP]

Taxonomic identifier

221988 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Basfia

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP MF_01558
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity. HAMAP MF_01558
Subunit structure	Homodimer By similarity. HAMAP MF_01558
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Cytidine deaminase HAMAP MF_01558		PRO_0000171655
Regions
	Region	93 – 95	3	Substrate binding By similarity
Sites
	Active site	108	1	Proton donor By similarity
	Metal binding	106	1	Zinc; catalytic By similarity
	Metal binding	133	1	Zinc; catalytic By similarity
	Metal binding	136	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65RG8 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: BCBC87C2AD6984B5	FASTA	296	32,541
	10 20 30 40 50 60 MKNTIIKGLT DLVEQKRDNL IRQVVVQLEA QGYKAVLEQA TVQQFCRQFA LSPVEFALRC 70 80 90 100 110 120 LPVAACYALT PISQFNVGAI AIGQSGSFYF GANQEFVAAS MQQTVHAEQS AISHAWLAGE 130 140 150 160 170 180 KAIAHMVVNY TPCGHCRQFM NELNSAERLK IHLPHSQNNL LHNYLPDAFG PKDLNIQNVF 190 200 210 220 230 240 FDGQSHPFNY QGHDPLIRAA VEAASQSYAP YSQAFSGVAL QLGELIICGR YAENAAFNPT 250 260 270 280 290 FLPLQSALNY QRLQGLIDVK VSRVVMAEAK ADLTSLPMTQ SLAGAHLGLD IEYISL

References

[1]

"The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens." Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J. Nat. Biotechnol. 22:1275-1281(2004) [PubMed: 15378067] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MBEL55E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016827 Genomic DNA. Translation: AAU38442.1.
RefSeq	YP_089027.1. NC_006300.1.
3D structure databases
ProteinModelPortal	Q65RG8.
SMR	Q65RG8. Positions 70-272.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65RG8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3074778.
GenomeReviews	Gene locus MS1835 in contig AE016827_GR.
KEGG	msu:MS1835.
NMPDR	fig|221988.1.peg.1724.
PATRIC	22446939. VBIManSuc86752_1678.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0295.
HOGENOM	HBG591160.
OMA	NRSHAPY.
PhylomeDB	Q65RG8.
ProtClustDB	PRK09027.
Enzyme and pathway databases
BioCyc	MSUC221988:MS1835-MONOMER.
Family and domain databases
HAMAP	MF_01558. Cyt_deam. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn-bd. IPR013171. Cyd/dCyd_deaminase_Zn-bd. IPR006263. Cyt_deam_dimer. IPR016193. Cytidine_deaminase-like. IPR020797. Cytidine_deaminase_bacteria. [Graphical view]
KO	K01489.
PANTHER	PTHR11644:SF12. PTHR11644:SF12. 1 hit.
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
PIRSF	PIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAM	SSF53927. Cytidine_deaminase-like. 2 hits.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_MANSM

Accession

Primary (citable) accession number: Q65RG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program