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Q65RG8

- CDD_MANSM

UniProt

Q65RG8 - CDD_MANSM

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Protein
Cytidine deaminase
Gene
cdd, MS1835
Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.UniRule annotation

Catalytic activityi

Cytidine + H2O = uridine + NH3.UniRule annotation
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.UniRule annotation

Cofactori

Binds 1 zinc ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi106 – 1061Zinc; catalytic By similarity
Active sitei108 – 1081Proton donor By similarity
Metal bindingi133 – 1331Zinc; catalytic By similarity
Metal bindingi136 – 1361Zinc; catalytic By similarity

GO - Molecular functioni

  1. cytidine deaminase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBMAN221988:GHGM-1889-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytidine deaminase (EC:3.5.4.5)
    Alternative name(s):
    Cytidine aminohydrolase
    Short name:
    CDA
    Gene namesi
    Name:cdd
    Ordered Locus Names:MS1835
    OrganismiMannheimia succiniciproducens (strain MBEL55E)
    Taxonomic identifieri221988 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
    ProteomesiUP000000607: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Cytidine deaminaseUniRule annotation
    PRO_0000171655Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi221988.MS1835.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65RG8.
    SMRiQ65RG8. Positions 70-272.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 14482CMP/dCMP deaminase zinc-binding
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni93 – 953Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0295.
    HOGENOMiHOG000218617.
    KOiK01489.
    OMAiNRSHAPY.
    OrthoDBiEOG6XDH25.

    Family and domain databases

    HAMAPiMF_01558. Cyt_deam.
    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR013171. Cyd/dCyd_deaminase_Zn-bd.
    IPR006263. Cyt_deam_dimer.
    IPR016193. Cytidine_deaminase-like.
    IPR020797. Cytidine_deaminase_bacteria.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    PF08211. dCMP_cyt_deam_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006334. Cdd_plus_pseudo. 1 hit.
    SUPFAMiSSF53927. SSF53927. 2 hits.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q65RG8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNTIIKGLT DLVEQKRDNL IRQVVVQLEA QGYKAVLEQA TVQQFCRQFA    50
    LSPVEFALRC LPVAACYALT PISQFNVGAI AIGQSGSFYF GANQEFVAAS 100
    MQQTVHAEQS AISHAWLAGE KAIAHMVVNY TPCGHCRQFM NELNSAERLK 150
    IHLPHSQNNL LHNYLPDAFG PKDLNIQNVF FDGQSHPFNY QGHDPLIRAA 200
    VEAASQSYAP YSQAFSGVAL QLGELIICGR YAENAAFNPT FLPLQSALNY 250
    QRLQGLIDVK VSRVVMAEAK ADLTSLPMTQ SLAGAHLGLD IEYISL 296
    Length:296
    Mass (Da):32,541
    Last modified:October 25, 2004 - v1
    Checksum:iBCBC87C2AD6984B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016827 Genomic DNA. Translation: AAU38442.1.
    RefSeqiYP_089027.1. NC_006300.1.

    Genome annotation databases

    EnsemblBacteriaiAAU38442; AAU38442; MS1835.
    GeneIDi3074778.
    KEGGimsu:MS1835.
    PATRICi22446939. VBIManSuc86752_1678.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016827 Genomic DNA. Translation: AAU38442.1 .
    RefSeqi YP_089027.1. NC_006300.1.

    3D structure databases

    ProteinModelPortali Q65RG8.
    SMRi Q65RG8. Positions 70-272.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 221988.MS1835.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU38442 ; AAU38442 ; MS1835 .
    GeneIDi 3074778.
    KEGGi msu:MS1835.
    PATRICi 22446939. VBIManSuc86752_1678.

    Phylogenomic databases

    eggNOGi COG0295.
    HOGENOMi HOG000218617.
    KOi K01489.
    OMAi NRSHAPY.
    OrthoDBi EOG6XDH25.

    Enzyme and pathway databases

    BioCyci BMAN221988:GHGM-1889-MONOMER.

    Family and domain databases

    HAMAPi MF_01558. Cyt_deam.
    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR013171. Cyd/dCyd_deaminase_Zn-bd.
    IPR006263. Cyt_deam_dimer.
    IPR016193. Cytidine_deaminase-like.
    IPR020797. Cytidine_deaminase_bacteria.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    PF08211. dCMP_cyt_deam_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006334. Cdd_plus_pseudo. 1 hit.
    SUPFAMi SSF53927. SSF53927. 2 hits.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
      Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
      Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MBEL55E.

    Entry informationi

    Entry nameiCDD_MANSM
    AccessioniPrimary (citable) accession number: Q65RG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: October 25, 2004
    Last modified: May 14, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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