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Q65RB1

- HISX_MANSM

UniProt

Q65RB1 - HISX_MANSM

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei127 – 1271NADUniRule annotation
    Binding sitei185 – 1851NADUniRule annotation
    Binding sitei208 – 2081NADUniRule annotation
    Binding sitei234 – 2341SubstrateUniRule annotation
    Metal bindingi256 – 2561ZincUniRule annotation
    Binding sitei256 – 2561SubstrateUniRule annotation
    Metal bindingi259 – 2591ZincUniRule annotation
    Binding sitei259 – 2591SubstrateUniRule annotation
    Active sitei323 – 3231Proton acceptorUniRule annotation
    Active sitei324 – 3241Proton acceptorUniRule annotation
    Binding sitei324 – 3241SubstrateUniRule annotation
    Metal bindingi357 – 3571ZincUniRule annotation
    Binding sitei357 – 3571SubstrateUniRule annotation
    Binding sitei411 – 4111SubstrateUniRule annotation
    Metal bindingi416 – 4161ZincUniRule annotation
    Binding sitei416 – 4161SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciBMAN221988:GHGM-1947-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:MS1892
    OrganismiMannheimia succiniciproducens (strain MBEL55E)
    Taxonomic identifieri221988 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
    ProteomesiUP000000607: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Histidinol dehydrogenasePRO_0000135793Add
    BLAST

    Proteomic databases

    PRIDEiQ65RB1.

    Interactioni

    Protein-protein interaction databases

    STRINGi221988.MS1892.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65RB1.
    SMRiQ65RB1. Positions 6-428.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiGFLFHAN.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q65RB1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTLIWKDLT EQEKKQALTR PAISAAGNIK DAVDAIRENV VANGDKALFE    50
    LSEKFDRVKL NSLEVSEQQI EEAAQRLPEE LKQAIQNAKK NIEAFHLAQV 100
    PVEADVETQS GVRCQVLTRP INRVGLYIPG GSAPLFSTVL MLAIPAKIAG 150
    CKKIVLCSPP PIADAILYAA NLCGVETIYQ VGGAQAVVAM AFGTETVAKV 200
    DKIFGPGNAF VTEAKRQVSQ AVNGAAIDMQ AGPSEVLVLA DENADPDFVA 250
    SDLLSQAEHG ADSQVILVTP SERLALETEL AVERQLTTLP RSEIAQKALA 300
    HSRIFIAENL QQCVEISNEY APEHLVVQVQ NARDLLSNID NAGSIFLGAY 350
    SPESMGDYAS GTNHVLPTYG YTRTSSSLGL ADFSKRMTVQ ELSPQGFKDL 400
    AKTVEVMAAA ERLDAHKQAV SIRLAKIK 428
    Length:428
    Mass (Da):46,088
    Last modified:October 25, 2004 - v1
    Checksum:i7923F52A6F7C11AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016827 Genomic DNA. Translation: AAU38499.1.
    RefSeqiWP_011201052.1. NC_006300.1.
    YP_089084.1. NC_006300.1.

    Genome annotation databases

    EnsemblBacteriaiAAU38499; AAU38499; MS1892.
    GeneIDi3075501.
    KEGGimsu:MS1892.
    PATRICi22447045. VBIManSuc86752_1729.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016827 Genomic DNA. Translation: AAU38499.1 .
    RefSeqi WP_011201052.1. NC_006300.1.
    YP_089084.1. NC_006300.1.

    3D structure databases

    ProteinModelPortali Q65RB1.
    SMRi Q65RB1. Positions 6-428.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 221988.MS1892.

    Proteomic databases

    PRIDEi Q65RB1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU38499 ; AAU38499 ; MS1892 .
    GeneIDi 3075501.
    KEGGi msu:MS1892.
    PATRICi 22447045. VBIManSuc86752_1729.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi GFLFHAN.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci BMAN221988:GHGM-1947-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
      Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
      Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MBEL55E.

    Entry informationi

    Entry nameiHISX_MANSM
    AccessioniPrimary (citable) accession number: Q65RB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3