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Q65R35 (AROB_MANSM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:MS1968
OrganismMannheimia succiniciproducens (strain MBEL55E) [Complete proteome] [HAMAP]
Taxonomic identifier221988 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Basfia

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3623623-dehydroquinate synthase HAMAP MF_00110
PRO_0000231097

Sequences

Sequence LengthMass (Da)Tools
Q65R35 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 83FA78391007D45D

FASTA36239,697
        10         20         30         40         50         60 
MVCVNVELKE RRYPIYIGEN LLTDTGVYPV KMGDKVMIVS NPTVAQYYLT PVTETLEKLG 

        70         80         90        100        110        120 
CQVSHVLLPD GEKYKTLDSL NMIFTALLKE NHGRDTTLIA LGGGVIGDVT GYAAASYQRG 

       130        140        150        160        170        180 
IRFIQIPTTL LAQVDSSVGG KTAVNHELGK NMIGAFYQPC TVIIDTRTLV TLPKREVNAG 

       190        200        210        220        230        240 
LAEVIKYGAI LDLPFFEWLE AHIDNLVALN QQDLQYCIAR CCQIKADVVA RDETEKGDRA 

       250        260        270        280        290        300 
LLNLGHTFGH AIETHLGYGN WLHGEAVAAG SMMAAVLSEK LGDLSYSEVA RLEKLLARAN 

       310        320        330        340        350        360 
LPTVSPDTMQ AEDYLPHMMR DKKVLAGKLR LVLLKTLGQA YVASDTDKSL VLDAIRVCSQ 


NN

« Hide

References

[1]"The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
Nat. Biotechnol. 22:1275-1281(2004) [PubMed: 15378067] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MBEL55E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016827 Genomic DNA. Translation: AAU38575.1.
RefSeqYP_089160.1. NC_006300.1.

3D structure databases

ProteinModelPortalQ65R35.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ65R35.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3075569.
GenomeReviewsGene locus MS1968 in contig AE016827_GR.
KEGGmsu:MS1968.
NMPDRfig|221988.1.peg.1852.
PATRIC22447185. VBIManSuc86752_1799.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
PhylomeDBQ65R35.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycMSUC221988:MS1968-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_MANSM
AccessionPrimary (citable) accession number: Q65R35
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 25, 2004
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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