Q65PG8 (PTH_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29

Gene names

Name:	pth
Synonyms:	spoVC
Ordered Locus Names:	BLi00066, BL00517

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity. HAMAP MF_00083
Subcellular location	Cytoplasm By similarity HAMAP MF_00083.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_0000187690

Sequences

	Sequence		Length	Mass (Da)
	Q65PG8 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: CFB79D8B0A971827	FASTA	188	20,924
	10 20 30 40 50 60 MLVFAGLGNP GKTYENTRHN VGFMTIDELS KEWNIPLDKT KFNGQYGIGF VSGKKVLLVK 70 80 90 100 110 120 PLTYMNLSGE CLRPLLDYYE IPVDNLKVIY DDLDLPTGRI RLRTKGSAGG HNGIKSTIQH 130 140 150 160 170 180 LGTSEFNRIR IGIGRPVNGM KVVDYVLGAF TDEEEPAIKE AVRQSAKACE ASLEKPFLEV MNEFNAKV

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017333 Genomic DNA. Translation: AAU39046.1. CP000002 Genomic DNA. Translation: AAU21701.1.
RefSeq	YP_077339.1. NC_006270.3. YP_089739.1. NC_006322.1.
3D structure databases
ProteinModelPortal	Q65PG8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65PG8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000057806; EBBACP00000056337; EBBACG00000057797. EBBACT00000058628; EBBACP00000057061; EBBACG00000058619.
GeneID	3027753. 3101218.
GenomeReviews	Gene locus BLi00066 in contig AE017333_GR. Gene locus BL00517 in contig CP000002_GR.
KEGG	bld:BLi00066. bli:BL00517.
NMPDR	fig|279010.5.peg.1347.
PATRIC	18945611. VBIBacLic203714_0059.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0193.
GeneTree	EBGT00050000001189.
HOGENOM	HBG610927.
OMA	NTFMNNS.
PhylomeDB	Q65PG8.
ProtClustDB	PRK05426.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI00066-MONOMER. BLIC279010:BL00517-MONOMER.
Family and domain databases
HAMAP	MF_00083. Pept_tRNA_hydro_bact. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
KO	K01056.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
SUPFAM	SSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMs	TIGR00447. Pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_BACLD

Accession

Primary (citable) accession number: Q65PG8
Secondary accession number(s): Q62ZV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program