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Protein

Protein-arginine kinase

Gene

mcsB

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.UniRule annotation

Catalytic activityi

ATP + a [protein]-L-arginine = ADP + a [protein]-N(omega)-phospho-L-arginine.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921ATPUniRule annotation
Binding sitei125 – 1251ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 315ATPUniRule annotation
Nucleotide bindingi176 – 1805ATPUniRule annotation
Nucleotide bindingi207 – 2126ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-105-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine kinaseUniRule annotation (EC:2.7.14.1UniRule annotation)
Gene namesi
Name:mcsBUniRule annotation
Ordered Locus Names:BLi00103, BL03260
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Protein-arginine kinasePRO_1000025869Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi00103.

Structurei

3D structure databases

ProteinModelPortaliQ65PD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 254231Phosphagen kinase C-terminalUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.UniRule annotation
Contains 1 phosphagen kinase C-terminal domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG41066A3. Bacteria.
COG3869. LUCA.
HOGENOMiHOG000082112.
KOiK19405.
OMAiNESMLRI.
OrthoDBiEOG6NKR1D.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
HAMAPiMF_00602. Prot_Arg_kinase.
InterProiIPR023660. Arg_Kinase.
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
[Graphical view]
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65PD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQHFIQNA LSNWMRQEGP ESDIVLSSRI RLARNLDKVR FPTLFSNEEA
60 70 80 90 100
SAIIALFEEQ FTGYEVPGIG KFELVKMDQV QPLEKRVLVE KHLISPHLTE
110 120 130 140 150
ASFGACLLSE NEEVSIMLNE EDHIRIQCLF PGFQLSEALK AANQVDDWIE
160 170 180 190 200
DRIDYAFSEQ RGYLTSCPTN VGTGLRASVM MHLPALVLTR QINRIIPAIN
210 220 230 240 250
QLGLVVRGIY GEGSEALGNI FQISNQITLG KSEHDIVEDL NSVVAQLIEQ
260 270 280 290 300
ERSARKALYQ TSQIELEDRV YRSYGVLSNC RMIESKETAR CLSDVRLGID
310 320 330 340 350
LGIIKGLSSN ILNELMILTQ PGFLQQYSGG ALRPNERDIR RAALIRERLK
360
LENNGNRQED ETI
Length:363
Mass (Da):41,002
Last modified:October 25, 2004 - v1
Checksum:iFA7C8AB2DCC50A68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU21733.1.
AE017333 Genomic DNA. Translation: AAU39077.1.
RefSeqiWP_003178273.1. NC_006322.1.

Genome annotation databases

EnsemblBacteriaiAAU21733; AAU21733; BL03260.
AAU39077; AAU39077; BLi00103.
GeneIDi3029412.
KEGGibld:BLi00103.
bli:BL03260.
PATRICi18945685. VBIBacLic203714_0091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU21733.1.
AE017333 Genomic DNA. Translation: AAU39077.1.
RefSeqiWP_003178273.1. NC_006322.1.

3D structure databases

ProteinModelPortaliQ65PD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BLi00103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU21733; AAU21733; BL03260.
AAU39077; AAU39077; BLi00103.
GeneIDi3029412.
KEGGibld:BLi00103.
bli:BL03260.
PATRICi18945685. VBIBacLic203714_0091.

Phylogenomic databases

eggNOGiENOG41066A3. Bacteria.
COG3869. LUCA.
HOGENOMiHOG000082112.
KOiK19405.
OMAiNESMLRI.
OrthoDBiEOG6NKR1D.

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-105-MONOMER.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
HAMAPiMF_00602. Prot_Arg_kinase.
InterProiIPR023660. Arg_Kinase.
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
[Graphical view]
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46.

Entry informationi

Entry nameiMCSB_BACLD
AccessioniPrimary (citable) accession number: Q65PD7
Secondary accession number(s): Q62ZS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: January 20, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.