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Q65P46

- GLMS_BACLD

UniProt

Q65P46 - GLMS_BACLD

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
glmS, BLi00204, BL02704
Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei595 – 5951For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-206-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:BLi00204, BL02704
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 600599Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationPRO_0000135298Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi279010.BL02704.

Structurei

3D structure databases

ProteinModelPortaliQ65P46.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2Add
BLAST
Domaini283 – 422140SIS 1Add
BLAST
Domaini452 – 590139SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q65P46-1 [UniParc]FASTAAdd to Basket

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MCGIVGYIGQ LDAKEILLKG LEKLEYRGYD SAGIAVANED GVHVFKEKGR    50
IADLRAAVDA NVKSQAGIGH TRWATHGEPS RLNAHPHQSA SGRFTLVHNG 100
VIENYVQLTR EYLHDVTLKS DTDTEVVVQV IEQFVNNGLD TEEAFRQTLM 150
LLKGSYAIAL FDHENKETIY VAKNKSPLLV GLGDNFNVVA SDAMAMLQVT 200
NEYVELMDKE MVIVTDKKVV IKNLDGELMS RASYIAELDA SDIEKGTYPH 250
YMLKEIDEQP LVMRKIIQTY QDENGKLSIP GDISNAVAEA DRVYIIACGT 300
SYHAGLVGKQ FIETWAKVPA EVHVASEFSY NMPLLSEKPL FIFISQSGET 350
ADSRAVLVQV KKLGHKALTL TNVPGSTLSR EADYTLLLNA GPEIAVASTK 400
AYTAQIAVLA ILAAVTAESR GKELGFDLVK ELGIIGNAME ALCDQKDEME 450
MIAREYLTVT RNAFFIGRGL DYFVCLEGSL KLKEISYIQA EGFAGGELKH 500
GTIALIEDGT PVIALATQEH VNLSIRGNVK EVTARGANPC VISLKGLEEA 550
DDRFVLPEVH PELAPLVSVI PLQLIAYYAA LHRGCDVDKP RNLAKSVTVE 600
Length:600
Mass (Da):65,652
Last modified:January 23, 2007 - v3
Checksum:i1B4EBABCF4DFDAF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU39168.1.
CP000002 Genomic DNA. Translation: AAU21823.1.
RefSeqiYP_006711646.1. NC_006322.1.
YP_077461.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU21823; AAU21823; BL02704.
AAU39168; AAU39168; BLi00204.
GeneIDi3029128.
3099260.
KEGGibld:BLi00204.
bli:BL02704.
PATRICi18945891. VBIBacLic203714_0184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU39168.1 .
CP000002 Genomic DNA. Translation: AAU21823.1 .
RefSeqi YP_006711646.1. NC_006322.1.
YP_077461.1. NC_006270.3.

3D structure databases

ProteinModelPortali Q65P46.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279010.BL02704.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU21823 ; AAU21823 ; BL02704 .
AAU39168 ; AAU39168 ; BLi00204 .
GeneIDi 3029128.
3099260.
KEGGi bld:BLi00204.
bli:BL02704.
PATRICi 18945891. VBIBacLic203714_0184.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci BLIC279010:GJ2P-206-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiGLMS_BACLD
AccessioniPrimary (citable) accession number: Q65P46
Secondary accession number(s): Q62ZI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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