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Protein

Probable 5-dehydro-4-deoxyglucarate dehydratase

Gene

BLi00284

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + H2O + CO2.UniRule annotation

Pathwayi: D-glucarate degradation

This protein is involved in step 2 of the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable 5-dehydro-4-deoxyglucarate dehydratase (BLi00284)
This subpathway is part of the pathway D-glucarate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate, the pathway D-glucarate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-278-MONOMER.
UniPathwayiUPA00564; UER00628.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-dehydro-4-deoxyglucarate dehydrataseUniRule annotation (EC:4.2.1.41UniRule annotation)
Alternative name(s):
5-keto-4-deoxy-glucarate dehydrataseUniRule annotation
Short name:
KDGDHUniRule annotation
Gene namesi
Ordered Locus Names:BLi00284, BL01645
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Probable 5-dehydro-4-deoxyglucarate dehydratasePRO_1000045399Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi00284.

Structurei

3D structure databases

ProteinModelPortaliQ65NX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105UVJ. Bacteria.
COG0329. LUCA.
HOGENOMiHOG000173605.
KOiK01707.
OMAiFMAIRNR.
OrthoDBiEOG6W7235.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03249. KdgD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65NX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLRKAPEG ILGFPVAPFN REGKLEEEAL YENIRFLLDE GLEAVFIACG
60 70 80 90 100
SGEFQSLSTK EYEQMVEIAV SAADGKVPVY TGVGGNLSTA LEWARISEEK
110 120 130 140 150
GADGYLILPP YLIHGEQEGL YQYTKTIIES TDLNAIIYQR DNAVLTLEQI
160 170 180 190 200
QRLTDLEQLV GLKDGIGDMA LNISLSYTIG DRLGWLNGMP MAEVTMPAYA
210 220 230 240 250
PIGFTSYSSA ISNYIPHISR MFYEALLNGN DRLVKEIYEQ VIIPINEIRK
260 270 280 290 300
LRKGYAVSLI KAGMEIMGLH VKNTARPPIV PVEKEHCRQL ENILKNAMAR

YPKTTAAL
Length:308
Mass (Da):34,251
Last modified:October 25, 2004 - v1
Checksum:i0F642A9A2E4FA5AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU21891.2.
AE017333 Genomic DNA. Translation: AAU39243.1.
RefSeqiWP_011197512.1. NC_006322.1.

Genome annotation databases

EnsemblBacteriaiAAU21891; AAU21891; BL01645.
AAU39243; AAU39243; BLi00284.
GeneIDi3028847.
KEGGibld:BLi00284.
bli:BL01645.
PATRICi18946059. VBIBacLic203714_0268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU21891.2.
AE017333 Genomic DNA. Translation: AAU39243.1.
RefSeqiWP_011197512.1. NC_006322.1.

3D structure databases

ProteinModelPortaliQ65NX1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BLi00284.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU21891; AAU21891; BL01645.
AAU39243; AAU39243; BLi00284.
GeneIDi3028847.
KEGGibld:BLi00284.
bli:BL01645.
PATRICi18946059. VBIBacLic203714_0268.

Phylogenomic databases

eggNOGiENOG4105UVJ. Bacteria.
COG0329. LUCA.
HOGENOMiHOG000173605.
KOiK01707.
OMAiFMAIRNR.
OrthoDBiEOG6W7235.

Enzyme and pathway databases

UniPathwayiUPA00564; UER00628.
BioCyciBLIC279010:GJ2P-278-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03249. KdgD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46.

Entry informationi

Entry nameiKDGD_BACLD
AccessioniPrimary (citable) accession number: Q65NX1
Secondary accession number(s): Q62ZB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.