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Q65NN2 (ROCA_BACLD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-pyrroline-5-carboxylate dehydrogenase
Short name=P5C dehydrogenase
EC=1.5.1.12
Gene names
Name:rocA
Ordered Locus Names:BLi00374, BL01710
OrganismBacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]
Taxonomic identifier279010 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H. HAMAP MF_00733

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. HAMAP MF_00733

Sequence similarities

Belongs to the aldehyde dehydrogenase family. RocA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5165161-pyrroline-5-carboxylate dehydrogenase HAMAP MF_00733
PRO_0000056510

Sites

Active site2871 By similarity
Active site3211 By similarity

Secondary structure

1 ................................................................. 516
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q65NN2 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 9BB008CC70ABBFDB

FASTA51656,655
        10         20         30         40         50         60 
MTTPYKHEPF TNFGIEENRK AFEKALETVN NEWLGQSYPL VIDGERYETE NKIVSINPAN 

        70         80         90        100        110        120 
KEEVVGTVSK ATQDHAEKAI QAAAKAFETW RYTDPEERAA VLFRAVAKVR RKKHEFSALL 

       130        140        150        160        170        180 
VKEAGKPWNE ADADTAEAID FMEYYARQMI ELAKGKPVNS REGERNQYVY TPTGVTVVIP 

       190        200        210        220        230        240 
PWNFLFAIMA GTTVAPIVTG NTVVLKPASA APVIAAKFVE VLEESGLPKG VVNFVPGSGA 

       250        260        270        280        290        300 
EVGDYLVDHP KTSIITFTGS REVGTRIFER AAKVQPGQTH LKQVIAEMGG KDTVVVDEDC 

       310        320        330        340        350        360 
DIELAAQSIF TSAFGFAGQK CSAGSRAVVH EKVYDEVLKR VIEITESKKV GEPDSADVYM 

       370        380        390        400        410        420 
GPVIDQASFN KIMDYIEIGK EEGRLVSGGK GDDSKGYFIE PTIFADLDPK ARLMQEEIFG 

       430        440        450        460        470        480 
PVVAFSKVSS FDEALEVANN TEYGLTGAVI TKNRDHINRA KQEFHVGNLY FNRNCTGAIV 

       490        500        510 
GYHPFGGFKM SGTDSKAGGP DYLALHMQAK TISEMF

« Hide

References

[1]"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13 / ATCC 14580.
[2]"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species."
Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. expand/collapse author list , Galleron N., Ehrlich S.D., Berka R.M.
Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017333 Genomic DNA. Translation: AAU39332.1.
CP000002 Genomic DNA. Translation: AAU21978.1.
RefSeqYP_077616.1. NC_006270.3.
YP_090025.1. NC_006322.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3RJLX-ray2.20A/B/C/D/E/F/G/H1-516[»]
ProteinModelPortalQ65NN2.
SMRQ65NN2. Positions 3-516.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ65NN2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000056085; EBBACP00000054616; EBBACG00000056076.
EBBACT00000062359; EBBACP00000060792; EBBACG00000062350.
GeneID3027308.
3097821.
GenomeReviewsGene locus BLi00374 in contig AE017333_GR.
Gene locus BL01710 in contig CP000002_GR.
KEGGbld:BLi00374.
bli:BL01710.
NMPDRfig|279010.5.peg.2227.
PATRIC18946245. VBIBacLic203714_0361.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
GeneTreeEBGT00070000031871.
HOGENOMHBG752218.
OMATPYKHEP.
PhylomeDBQ65NN2.
ProtClustDBPRK03137.

Enzyme and pathway databases

BioCycBLIC279010-1:BLI00374-MONOMER.
BLIC279010:BL01710-MONOMER.

Family and domain databases

HAMAPMF_00733. RocA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005932. Delta1-pyrroline-5-COlate_DH-2.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00294.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01237. D1pyr5carbox2. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameROCA_BACLD
AccessionPrimary (citable) accession number: Q65NN2
Secondary accession number(s): Q62Z30
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 25, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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