Reviewed, UniProtKB/Swiss-Prot Q65NA1 (MTLD_BACLD)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	BLi00507, BL02815

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 379	379	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000011795
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65NA1-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 9B356236E0A70F1E	FASTA	379	41,676
	10 20 30 40 50 60 MIALHFGAGN IGRGFIGALL CKSGYDVVFA DVNDAVINEL NDKGRYTVEM ADAGRKQETI 70 80 90 100 110 120 GPVRAINSAT QLDELYDLIA KADLVTTAVG PAVLKLIAEP IAEGLKRRMK INKQPLNIIA 130 140 150 160 170 180 CENMIGGSAH LREEIFARLT ETERAAISDS VGFPNSAVDR IVPIQHHDDP LKVTVEPFFE 190 200 210 220 230 240 WAVDQTEFAG KVPDIEGVTY VADLAPFIER KLFTVNTGHA MAAYAGYKKG LKTIKDAIHH 250 260 270 280 290 300 PEVRQTVAGA LEETGRYLVQ TYDFTQEEHR AYMTKIIGRF ENECLSDDVT RVARSPLRKL 310 320 330 340 350 360 GRDDRLVGPA RKLCDLGFEP VRLAEGIALA LQFDCADDPE AVQLQSMIAE KGYAGVLRDV 370 CGLEEDHSLF KLVISHLKA

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:RESEARCH077.1-RESEARCH077.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000002 Genomic DNA. Translation: AAU22103.1. AE017333 Genomic DNA. Translation: AAU39463.1.
RefSeq	YP_077741.1. YP_090156.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q65NA1.
Genome annotation databases
GeneID	3030175. 3098227.
GenomeReviews	Gene locus BLi00507 in contig AE017333_GR. Gene locus BL02815 in contig CP000002_GR.
KEGG	bld:BLi00507. bli:BL02815.
NMPDR	fig|279010.5.peg.593.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q65NA1.
OMA	VDRIVPN.
Enzyme and pathway databases
BioCyc	BLIC279010:BL02815-MON.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_BACLD

Accession

Primary (citable) accession number: Q65NA1
Secondary accession number(s): Q62YQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 25, 2004
Last modified:	November 3, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)