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Protein

Serine-protein kinase RsbW

Gene

rsbW

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-551-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-protein kinase RsbWUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Anti-sigma-B factorUniRule annotation
Sigma-B negative effector RsbWUniRule annotation
Gene namesi
Name:rsbWUniRule annotation
Ordered Locus Names:BLi00559, BL02207
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Serine-protein kinase RsbWPRO_0000203531Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi00559.

Structurei

3D structure databases

ProteinModelPortaliQ65N49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2172. LUCA.
HOGENOMiHOG000269932.
KOiK04757.
OMAiKMGFSYE.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00638. Anti_sigma_B. 1 hit.
InterProiIPR003594. HATPase_C.
IPR010193. RsbW.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01924. rsbW_low_gc. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65N49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRAADYIEM KSPAKPEYVG IIRLTLSGIA SKMGYSYDDI EDLKIAVSEA
60 70 80 90 100
CTNAVQHAYK ADNNTGEVSV RFGVFEDRLE IVVADQGDSF DIQDKQKELG
110 120 130 140 150
PYSPEHTVDQ LSEGGLGLYL METLMDEVHV QIDSGVTVSM TKFLNRERVD
160
DGTTVQNYET N
Length:161
Mass (Da):17,923
Last modified:October 25, 2004 - v1
Checksum:i1B59D55491F6EDD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU39515.1.
CP000002 Genomic DNA. Translation: AAU22160.1.
RefSeqiWP_003179142.1. NC_006322.1.

Genome annotation databases

EnsemblBacteriaiAAU22160; AAU22160; BL02207.
AAU39515; AAU39515; BLi00559.
GeneIDi3030460.
KEGGibld:BLi00559.
bli:BL02207.
PATRICi18946635. VBIBacLic203714_0556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU39515.1.
CP000002 Genomic DNA. Translation: AAU22160.1.
RefSeqiWP_003179142.1. NC_006322.1.

3D structure databases

ProteinModelPortaliQ65N49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BLi00559.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU22160; AAU22160; BL02207.
AAU39515; AAU39515; BLi00559.
GeneIDi3030460.
KEGGibld:BLi00559.
bli:BL02207.
PATRICi18946635. VBIBacLic203714_0556.

Phylogenomic databases

eggNOGiCOG2172. LUCA.
HOGENOMiHOG000269932.
KOiK04757.
OMAiKMGFSYE.

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-551-MONOMER.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00638. Anti_sigma_B. 1 hit.
InterProiIPR003594. HATPase_C.
IPR010193. RsbW.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01924. rsbW_low_gc. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRSBW_BACLD
AccessioniPrimary (citable) accession number: Q65N49
Secondary accession number(s): Q62YJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 25, 2004
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.