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Reviewed, UniProtKB/Swiss-Prot Q65MS6 (PUR5_BACLD)

Last modified November 3, 2009. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase
    EC=6.3.3.1
Alternative name(s):
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    AIR synthase
Gene names
Name: purM
Ordered Locus Names: BLi00701, BL01484
OrganismBacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]
Taxonomic identifier279010 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillus

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the AIR synthase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741
PRO_0000258331

Experimental info

Sequence conflict11M → ML in AAU39638. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q65MS6-1 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: 1B68F9EBA0283609

FASTA34636,584
        10         20         30         40         50         60 
MSESYKNAGV DIEAGYEAVK RMKKHVERTK RIGAMGGLGG FGGMFDLSEL PYKQPVLISG 

        70         80         90        100        110        120 
TDGVGTKLKL AFAMDKHDTI GIDAVAMCVN DVLAQGAEPL FFLDYLAVGK ADPVKIEEIV 

       130        140        150        160        170        180 
KGVAEGCVQS GSALVGGETA EMPGLYTEDE YDIAGFSVGA AEKDGIVTGE NISEGHLLIG 

       190        200        210        220        230        240 
LSSSGLHSNG FSLVRKVLLE DAGLNLDETY APFERPLGEE LLEPTKIYVK PVLEAVKSGK 

       250        260        270        280        290        300 
IAGMAHVTGG GFIENLPRMM PDGLGVEIDI GSWPVPPIFP FIQEKGGLKS EEMFNVFNMG 

       310        320        330        340 
IGFVLAVKEE DMTDVIQTLE NNGEKAYLIG RVKAGSGVVF GGAGLS 

« Hide

References

[1]"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species."
Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. expand/collapse author list , Galleron N., Ehrlich S.D., Berka R.M.
Genome Biol. 5:RESEARCH077.1-RESEARCH077.12(2004) [PubMed: 15461803] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

AE017333 Genomic DNA. Translation: AAU39638.1.
CP000002 Genomic DNA. Translation: AAU22287.1.
RefSeqYP_077925.1.
YP_090331.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ65MS6.

Genome annotation databases

GeneID3031170.
3099228.
GenomeReviewsGene locus BLi00701 in contig AE017333_GR.
Gene locus BL01484 in contig CP000002_GR.
KEGGbld:BLi00701.
bli:BL01484.
NMPDRfig|279010.5.peg.1009.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ65MS6.
OMAVHGLAHI.

Enzyme and pathway databases

BioCycBLIC279010:BL01484-MON.

Family and domain databases

HAMAPMF_00741.
[Tree]
InterProIPR000728. AIR_synth.
IPR010918. AIR_synth_C.
IPR004733. PurM_cligase.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00878. purM. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_BACLD
AccessionPrimary (citable) accession number: Q65MS6
Secondary accession number(s): Q62Y71
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 3, 2009
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents