Q65MS6 (PUR5_BACLD) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 57.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Phosphoribosylformylglycinamidine cyclo-ligase EC=6.3.3.1 Alternative name(s): AIR synthase AIRS Phosphoribosyl-aminoimidazole synthetase | ||||
| Gene names |
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| Organism | Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 279010 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 346 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741_B |
| Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741_B |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00741_B. |
| Sequence similarities | Belongs to the AIR synthase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | 'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 346 | 346 | Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741_B | PRO_0000258331 | ||||
Experimental info | ||||||||
| Sequence conflict | 1 | 1 | M → ML in AAU39638. Ref.1 | |||||
Sequences
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References
| [1] | "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580. |
| [2] | "Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. Berka R.M.Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE017333 Genomic DNA. Translation: AAU39638.1. CP000002 Genomic DNA. Translation: AAU22287.1. |
| RefSeq | YP_077925.1. NC_006270.3. YP_090331.1. NC_006322.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1CLI based on UniProtKB P08178. |
| ProteinModelPortal | Q65MS6. |
| SMR | Q65MS6. Positions 13-340. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q65MS6. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBACT00000055587; EBBACP00000054118; EBBACG00000055578. EBBACT00000059244; EBBACP00000057677; EBBACG00000059235. |
| GeneID | 3031170. 3099228. |
| GenomeReviews | Gene locus BLi00701 in contig AE017333_GR. Gene locus BL01484 in contig CP000002_GR. |
| KEGG | bld:BLi00701. bli:BL01484. |
| NMPDR | fig|279010.5.peg.1009. |
| PATRIC | 18946929. VBIBacLic203714_0689. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0150. |
| GeneTree | EBGT00050000002660. |
| HOGENOM | HBG531222. |
| OMA | GIDMIAM. |
| PhylomeDB | Q65MS6. |
| ProtClustDB | PRK05385. |
Enzyme and pathway databases | |
| BioCyc | BLIC279010-1:BLI00701-MONOMER. BLIC279010:BL01484-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00741_B. AIRS_B. [Tree] |
| InterPro | IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view] |
| KO | K01933. |
| Pfam | PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view] |
| SUPFAM | SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit. |
| TIGRFAMs | TIGR00878. PurM. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PUR5_BACLD | ||||||||
| Accession | Primary (citable) accession number: Q65MS6 Secondary accession number(s): Q62Y71 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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