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Q65ML7

- GCH4_BACLD

UniProt

Q65ML7 - GCH4_BACLD

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, BLi00762, BL02349
Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei183 – 1831May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-755-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:BLi00762, BL02349
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300GTP cyclohydrolase FolE2UniRule annotation
PRO_0000147700Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BL02349.

Structurei

3D structure databases

ProteinModelPortaliQ65ML7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65ML7-1 [UniParc]FASTAAdd to Basket

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MERKLHLPAK PERHRRFGSV EAVKGIKPTD KEQMKDIQNT PNDYFFDIDH    50
VGVSNVSHPI LIASSLKPFT QTTIGAFSFT TSLARDRKGI NMSRLTEQLQ 100
RYHEANWTVD FHTLKDFAKD LAGNMEQESA SVSVSFPWYF ERISPETKLS 150
GLMHADIHMT VSYHENKGFS QTAGITAHAT TLCPCSKEIS EYSAHNQRGI 200
IKITAHINEQ AEMPDDFKAE LLAAAETNAS AKLHPVLKRP DEKRVTEQAY 250
ENPRFVEDVL RLTAADLYEM DWISAFEIEC RNEESIHLHD AVARLSFSKC 300
Length:300
Mass (Da):34,080
Last modified:October 25, 2004 - v1
Checksum:iA23E6D14EB8E1CF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU39697.1.
CP000002 Genomic DNA. Translation: AAU22347.1.
RefSeqiYP_006712167.1. NC_006322.1.
YP_077985.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU22347; AAU22347; BL02349.
AAU39697; AAU39697; BLi00762.
GeneIDi3031477.
3098927.
KEGGibld:BLi00762.
bli:BL02349.
PATRICi18947055. VBIBacLic203714_0752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU39697.1 .
CP000002 Genomic DNA. Translation: AAU22347.1 .
RefSeqi YP_006712167.1. NC_006322.1.
YP_077985.1. NC_006270.3.

3D structure databases

ProteinModelPortali Q65ML7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279010.BL02349.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU22347 ; AAU22347 ; BL02349 .
AAU39697 ; AAU39697 ; BLi00762 .
GeneIDi 3031477.
3098927.
KEGGi bld:BLi00762.
bli:BL02349.
PATRICi 18947055. VBIBacLic203714_0752.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci BLIC279010:GJ2P-755-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiGCH4_BACLD
AccessioniPrimary (citable) accession number: Q65ML7
Secondary accession number(s): Q62Y11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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