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Q65ML7

- GCH4_BACLD

UniProt

Q65ML7 - GCH4_BACLD

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei183 – 1831May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciBLIC279010:GJ2P-755-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:BLi00762, BL02349
    OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
    Taxonomic identifieri279010 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300GTP cyclohydrolase FolE2PRO_0000147700Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi279010.BL02349.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65ML7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q65ML7-1 [UniParc]FASTAAdd to Basket

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    MERKLHLPAK PERHRRFGSV EAVKGIKPTD KEQMKDIQNT PNDYFFDIDH    50
    VGVSNVSHPI LIASSLKPFT QTTIGAFSFT TSLARDRKGI NMSRLTEQLQ 100
    RYHEANWTVD FHTLKDFAKD LAGNMEQESA SVSVSFPWYF ERISPETKLS 150
    GLMHADIHMT VSYHENKGFS QTAGITAHAT TLCPCSKEIS EYSAHNQRGI 200
    IKITAHINEQ AEMPDDFKAE LLAAAETNAS AKLHPVLKRP DEKRVTEQAY 250
    ENPRFVEDVL RLTAADLYEM DWISAFEIEC RNEESIHLHD AVARLSFSKC 300
    Length:300
    Mass (Da):34,080
    Last modified:October 25, 2004 - v1
    Checksum:iA23E6D14EB8E1CF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017333 Genomic DNA. Translation: AAU39697.1.
    CP000002 Genomic DNA. Translation: AAU22347.1.
    RefSeqiYP_006712167.1. NC_006322.1.
    YP_077985.1. NC_006270.3.

    Genome annotation databases

    EnsemblBacteriaiAAU22347; AAU22347; BL02349.
    AAU39697; AAU39697; BLi00762.
    GeneIDi3031477.
    3098927.
    KEGGibld:BLi00762.
    bli:BL02349.
    PATRICi18947055. VBIBacLic203714_0752.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017333 Genomic DNA. Translation: AAU39697.1 .
    CP000002 Genomic DNA. Translation: AAU22347.1 .
    RefSeqi YP_006712167.1. NC_006322.1.
    YP_077985.1. NC_006270.3.

    3D structure databases

    ProteinModelPortali Q65ML7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 279010.BL02349.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU22347 ; AAU22347 ; BL02349 .
    AAU39697 ; AAU39697 ; BLi00762 .
    GeneIDi 3031477.
    3098927.
    KEGGi bld:BLi00762.
    bli:BL02349.
    PATRICi 18947055. VBIBacLic203714_0752.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci BLIC279010:GJ2P-755-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
      Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
      J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.

    Entry informationi

    Entry nameiGCH4_BACLD
    AccessioniPrimary (citable) accession number: Q65ML7
    Secondary accession number(s): Q62Y11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3