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Protein

L-cystine uptake protein TcyP

Gene

tcyP

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mediates uptake of L-cystine, the oxidized form of L-cysteine.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
L-cystine uptake protein TcyP
Alternative name(s):
Transporter of cystine TcyP
Gene namesi
Name:tcyP
Synonyms:yhcL
Ordered Locus Names:BLi00975, BL03177
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002797401 – 461L-cystine uptake protein TcyPAdd BLAST461

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi00975.

Structurei

3D structure databases

ProteinModelPortaliQ65M31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107R6U. Bacteria.
COG1823. LUCA.
HOGENOMiHOG000208777.
KOiK06956.
OMAiMLAMMIA.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiIPR001991. Na-dicarboxylate_symporter.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65M31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLFVVINII VMLGLMALLY MMQKKHVSFS KRVFTALGIG IVFGFALHFI
60 70 80 90 100
YGSSSETITQ TSDWFNIAGG GYVKLLQMIV MPLVFISILG AFTKLKLTHN
110 120 130 140 150
IGKISGLIIG LLIATTAVAA AVGIASALAF DLQAVHVDQG QAETMRGAEL
160 170 180 190 200
EQKSQDMEAK TLPQQIVELL PGNPFLDFTG ARPTSTIAVV IFAAFLGIAY
210 220 230 240 250
LGVNRKQPEQ AELFKKMVDA VYAIIMRVVT LILRLTPYGV LAIMTKTIAT
260 270 280 290 300
SDLDSIAKLG KFVIASYAAL IVMFIIHLLL ITFSGLNPVT YLKKAFPVLV
310 320 330 340 350
FAFTSRSSAG ALPLNIKTQR SLGVPEGIAN FAGSFGLSIG QNGCAGIYPA
360 370 380 390 400
MLAIMIAPTV GQNPLDPSFL FTVIAVVAIS SFGVAGVGGG ATFAALLVLS
410 420 430 440 450
ALNMPVALAG LLISVEPLID MGRTALNVSG SMTSGLVTSK VTNELEKDTY
460
QDRTNIIEAE V
Length:461
Mass (Da):48,892
Last modified:October 25, 2004 - v1
Checksum:iB245D3A450A0A610
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU39883.1.
CP000002 Genomic DNA. Translation: AAU22540.1.
RefSeqiWP_003180048.1. NC_006322.1.

Genome annotation databases

EnsemblBacteriaiAAU22540; AAU22540; BL03177.
AAU39883; AAU39883; BLi00975.
GeneIDi3029851.
KEGGibld:BLi00975.
bli:BL03177.
PATRICi18947489. VBIBacLic203714_0949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU39883.1.
CP000002 Genomic DNA. Translation: AAU22540.1.
RefSeqiWP_003180048.1. NC_006322.1.

3D structure databases

ProteinModelPortaliQ65M31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BLi00975.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU22540; AAU22540; BL03177.
AAU39883; AAU39883; BLi00975.
GeneIDi3029851.
KEGGibld:BLi00975.
bli:BL03177.
PATRICi18947489. VBIBacLic203714_0949.

Phylogenomic databases

eggNOGiENOG4107R6U. Bacteria.
COG1823. LUCA.
HOGENOMiHOG000208777.
KOiK06956.
OMAiMLAMMIA.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiIPR001991. Na-dicarboxylate_symporter.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTCYP_BACLD
AccessioniPrimary (citable) accession number: Q65M31
Secondary accession number(s): Q62XG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 25, 2004
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.