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Protein

Allantoinase

Gene

allB

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Pathway: (S)-allantoin degradation

This protein is involved in step 1 of the subpathway that synthesizes allantoate from (S)-allantoin.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Allantoinase (allB)
This subpathway is part of the pathway (S)-allantoin degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes allantoate from (S)-allantoin, the pathway (S)-allantoin degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Zinc 1UniRule annotation
Metal bindingi61 – 611Zinc 1UniRule annotation
Metal bindingi150 – 1501Zinc 1; via carbamate groupUniRule annotation
Metal bindingi150 – 1501Zinc 2; via carbamate groupUniRule annotation
Metal bindingi190 – 1901Zinc 2UniRule annotation
Metal bindingi246 – 2461Zinc 2UniRule annotation
Metal bindingi319 – 3191Zinc 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-1115-MONOMER.
UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
Alternative name(s):
Allantoin-utilizing enzymeUniRule annotation
Gene namesi
Name:allBUniRule annotation
Synonyms:pucHUniRule annotation
Ordered Locus Names:BLi01126, BL01094
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454AllantoinasePRO_0000317671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei150 – 1501N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi279010.BLi01126.

Structurei

3D structure databases

ProteinModelPortaliQ65LN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DHOase family. Allantoinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0044.
HOGENOMiHOG000219146.
KOiK01466.
OMAiIILFAKE.
OrthoDBiEOG6KHFW6.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase.
InterProiIPR017593. Allantoinase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65LN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFDSIIKNG LVILENGEQE VEVGIKDGKI AAIGQDLGTS AKIIDAKGSI
60 70 80 90 100
VSPGMIDAHV HITEPGGGYR DEWEGYDTGT RAAAKGGVTT FIEMPLNQVP
110 120 130 140 150
ATVDEESIQE KFKAGKGKLS VDVASYGGLV PFDLDGGIQE LDSNGVVAYK
160 170 180 190 200
CFLATCGDRS IEGDFMNVDD YSLYEGMKQI AKTGKILSIH AENAAITDKL
210 220 230 240 250
GEIASKNGET SLRAYVDSRP VFTEVEPIRK IILFAKETGC RVHIVHIACE
260 270 280 290 300
EGVDEIVKAQ QEGVDITCET CTHYLYFYKE ELDHIGPVVK CSPPIREQSR
310 320 330 340 350
LEGMWNRVLN GDISFVTSDH SPCTPDLKAT DNAFEAWGGI AGLQNNVDVL
360 370 380 390 400
FDEGVQKRNM PLSKFAAIIA TNPAKRFNLA SKGSIAVGKD ADFVFIKKDA
410 420 430 440 450
PYELKAEDLA YRHKISPYIG RKIGAQVVKT ILRGVEIYDK EKGISNEKVG

RFIP
Length:454
Mass (Da):49,488
Last modified:October 25, 2004 - v1
Checksum:iDE1502556AD04420
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU22686.1.
AE017333 Genomic DNA. Translation: AAU40034.1.
RefSeqiWP_011197731.1. NC_006322.1.
YP_006712506.1. NC_006322.1.
YP_078324.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU22686; AAU22686; BL01094.
AAU40034; AAU40034; BLi01126.
GeneIDi3030063.
KEGGibld:BLi01126.
bli:BL01094.
PATRICi18947811. VBIBacLic203714_1110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU22686.1.
AE017333 Genomic DNA. Translation: AAU40034.1.
RefSeqiWP_011197731.1. NC_006322.1.
YP_006712506.1. NC_006322.1.
YP_078324.1. NC_006270.3.

3D structure databases

ProteinModelPortaliQ65LN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BLi01126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU22686; AAU22686; BL01094.
AAU40034; AAU40034; BLi01126.
GeneIDi3030063.
KEGGibld:BLi01126.
bli:BL01094.
PATRICi18947811. VBIBacLic203714_1110.

Phylogenomic databases

eggNOGiCOG0044.
HOGENOMiHOG000219146.
KOiK01466.
OMAiIILFAKE.
OrthoDBiEOG6KHFW6.

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.
BioCyciBLIC279010:GJ2P-1115-MONOMER.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase.
InterProiIPR017593. Allantoinase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46.

Entry informationi

Entry nameiALLB_BACLD
AccessioniPrimary (citable) accession number: Q65LN0
Secondary accession number(s): Q62X22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 25, 2004
Last modified: June 24, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.