Reviewed, UniProtKB/Swiss-Prot Q65LF0 (ARGC_BACLD)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	BLi01206, BL03241

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112382
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65LF0-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: BEAB382DE4B808CB	FASTA	345	38,412
	10 20 30 40 50 60 MKIGIIGATG YGGAEIMRIM RTHPYADECI LYSSSDEGAR YDAAYPHLVK LTDQHLQPIE 70 80 90 100 110 120 VKRIANEIDF LFMAAPPGIS SRLTPQFDAY DIPIIDLSGD LRIQNPSVYE KWYKREAAPE 130 140 150 160 170 180 HVLQKAVYGL SELNREDIKT AQYIANPGCF PTAVLLGLAP LVKSGSINES FVIIDAKTGV 190 200 210 220 230 240 SGAGRKPSMG THFSEVNDNF KIYKVNEHQH TPEIEQTVKQ WNSAFKPITF STHLVPMTRG 250 260 270 280 290 300 IMATIYTELK DSMDAEQLQL IFSKFYKDSY FVRVRETGSF PATKEVYGSN FCDIGVTVDE 310 320 330 340 RTNRVTIVSV IDNLMKGAAG QAVQNFNIMN GLSETAGLEF TPIYP

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:RESEARCH077.1-RESEARCH077.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017333 Genomic DNA. Translation: AAU40114.1. CP000002 Genomic DNA. Translation: AAU22768.1.
RefSeq	YP_078406.1. YP_090807.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q65LF0.
Genome annotation databases
GeneID	3030195. 3098234.
GenomeReviews	Gene locus BLi01206 in contig AE017333_GR. Gene locus BL03241 in contig CP000002_GR.
KEGG	bld:BLi01206. bli:BL03241.
NMPDR	fig|279010.5.peg.2287.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q65LF0.
OMA	VCRIAVH.
Enzyme and pathway databases
BioCyc	BLIC279010:BL03241-MON.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BACLD

Accession

Primary (citable) accession number: Q65LF0
Secondary accession number(s): Q62WU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	October 25, 2004
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)