Q65LE3 (UPPP1_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 1
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1

Gene names

Name:	uppP1
Ordered Locus Names:	BLi01213, BL03255

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Undecaprenyl-diphosphatase 1 HAMAP MF_01006		PRO_0000151105
Regions
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	117 – 137	21	Helical; Potential
	Transmembrane	192 – 212	21	Helical; Potential
	Transmembrane	218 – 238	21	Helical; Potential
	Transmembrane	250 – 270	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q65LE3 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 0E2E9E2729AB6B17	FASTA	270	29,692
	10 20 30 40 50 60 MDFLVLIKYI LLGLLQGFTE PIPVSSSGHL VLAQHFLGLN IEGFSFELLM NAGSLIAVLL 70 80 90 100 110 120 VYKNDIFRLA VNGLSYVTTK NEKGKADFRF IIYLIIATIP AGVIGVLFDD EISAFFKDGV 130 140 150 160 170 180 RITAVTLLIT GLALFLIRNL RGRKSDGEIR LRDAVIIGFS QMVALVPGIS RSGATIVPAM 190 200 210 220 230 240 ALGLKSETAL RFSFLLYIPV SLGGTILSIT DIFHDPRLGE LFLPYLFAFI ASVIATYFSL 250 260 270 RWFMNIMAKG NLVYFSIYCF VIGIAVLIFA

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017333 Genomic DNA. Translation: AAU40121.1. CP000002 Genomic DNA. Translation: AAU22775.1.
RefSeq	YP_078413.1. NC_006270.3. YP_090814.1. NC_006322.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q65LE3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000057525; EBBACP00000056056; EBBACG00000057516. EBBACT00000062008; EBBACP00000060441; EBBACG00000061999.
GeneID	3030205. 3100472.
GenomeReviews	Gene locus BLi01213 in contig AE017333_GR. Gene locus BL03255 in contig CP000002_GR.
KEGG	bld:BLi01213. bli:BL03255.
NMPDR	fig|279010.5.peg.2382.
PATRIC	18947995. VBIBacLic203714_1202.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
GeneTree	EBGT00050000002490.
HOGENOM	HBG391969.
OMA	HMMWALI.
PhylomeDB	Q65LE3.
ProtClustDB	PRK12554.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI01213-MONOMER. BLIC279010:BL03255-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
KO	K06153.
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP1_BACLD

Accession

Primary (citable) accession number: Q65LE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program