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Q65LE3

- UPPP1_BACLD

UniProt

Q65LE3 - UPPP1_BACLD

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Protein

Undecaprenyl-diphosphatase 1

Gene
uppP1, BLi01213, BL03255
Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-1205-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 1 (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1
Gene namesi
Name:uppP1
Ordered Locus Names:BLi01213, BL03255
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121Helical; Reviewed predictionAdd
BLAST
Transmembranei88 – 10821Helical; Reviewed predictionAdd
BLAST
Transmembranei117 – 13721Helical; Reviewed predictionAdd
BLAST
Transmembranei192 – 21221Helical; Reviewed predictionAdd
BLAST
Transmembranei218 – 23821Helical; Reviewed predictionAdd
BLAST
Transmembranei250 – 27021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Undecaprenyl-diphosphatase 1UniRule annotationPRO_0000151105Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BL03255.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiNANEAVD.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65LE3-1 [UniParc]FASTAAdd to Basket

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MDFLVLIKYI LLGLLQGFTE PIPVSSSGHL VLAQHFLGLN IEGFSFELLM    50
NAGSLIAVLL VYKNDIFRLA VNGLSYVTTK NEKGKADFRF IIYLIIATIP 100
AGVIGVLFDD EISAFFKDGV RITAVTLLIT GLALFLIRNL RGRKSDGEIR 150
LRDAVIIGFS QMVALVPGIS RSGATIVPAM ALGLKSETAL RFSFLLYIPV 200
SLGGTILSIT DIFHDPRLGE LFLPYLFAFI ASVIATYFSL RWFMNIMAKG 250
NLVYFSIYCF VIGIAVLIFA 270
Length:270
Mass (Da):29,692
Last modified:October 25, 2004 - v1
Checksum:i0E2E9E2729AB6B17
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU40121.1.
CP000002 Genomic DNA. Translation: AAU22775.1.
RefSeqiYP_006712594.1. NC_006322.1.
YP_078413.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU22775; AAU22775; BL03255.
AAU40121; AAU40121; BLi01213.
GeneIDi3030205.
3100472.
KEGGibld:BLi01213.
bli:BL03255.
PATRICi18947995. VBIBacLic203714_1202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU40121.1 .
CP000002 Genomic DNA. Translation: AAU22775.1 .
RefSeqi YP_006712594.1. NC_006322.1.
YP_078413.1. NC_006270.3.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279010.BL03255.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU22775 ; AAU22775 ; BL03255 .
AAU40121 ; AAU40121 ; BLi01213 .
GeneIDi 3030205.
3100472.
KEGGi bld:BLi01213.
bli:BL03255.
PATRICi 18947995. VBIBacLic203714_1202.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi NANEAVD.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BLIC279010:GJ2P-1205-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiUPPP1_BACLD
AccessioniPrimary (citable) accession number: Q65LE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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