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Q65LA2

- NADK1_BACLD

UniProt

Q65LA2 - NADK1_BACLD

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Protein
NAD kinase 1
Gene
nadK1, BLi01255, BL05111
Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei46 – 461Proton acceptor By similarity
Binding sitei149 – 1491NAD By similarity
Binding sitei151 – 1511NAD By similarity
Binding sitei186 – 1861NAD; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 472NAD By similarity
Nucleotide bindingi123 – 1242NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-1247-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 1 (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase 1
Gene namesi
Name:nadK1
Ordered Locus Names:BLi01255, BL05111
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267NAD kinase 1UniRule annotation
PRO_0000229604Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BL05111.

Structurei

3D structure databases

ProteinModelPortaliQ65LA2.
SMRiQ65LA2. Positions 2-263.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000275803.
KOiK00858.
OMAiIQMSEIA.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65LA2-1 [UniParc]FASTAAdd to Basket

« Hide

MMKFAVSSKG NAVSDSLKSK IQTYLLDFGL ECDEEEPDIV ISVGGDGTLL    50
YAFHKYSGRL DKTAFVGVHT GHLGFYADWV PSEIEKLVIA IAKTPYQIVE 100
YPVLEVIVRY NDGSDEARYL ALNECTIKSI EGTLVTDVEI KGELFETFRG 150
DGLCLSTPSG STAYNKALGG AIIHPSIRAI QLAEMASINN RVFRTVGSPL 200
ILPEHHTCLI KPINDVTFQV AIDHLTLLHK DVKSIQCRVA NENIRFARFR 250
PFPFWKRVQD SFIGKGE 267
Length:267
Mass (Da):29,670
Last modified:October 25, 2004 - v1
Checksum:i4BBC6CD6CD5EA750
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU40162.1.
CP000002 Genomic DNA. Translation: AAU22817.2.
RefSeqiYP_006712636.1. NC_006322.1.
YP_078455.2. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU22817; AAU22817; BL05111.
AAU40162; AAU40162; BLi01255.
GeneIDi3030258.
3098767.
KEGGibld:BLi01255.
bli:BL05111.
PATRICi18948083. VBIBacLic203714_1246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU40162.1 .
CP000002 Genomic DNA. Translation: AAU22817.2 .
RefSeqi YP_006712636.1. NC_006322.1.
YP_078455.2. NC_006270.3.

3D structure databases

ProteinModelPortali Q65LA2.
SMRi Q65LA2. Positions 2-263.
ModBasei Search...

Protein-protein interaction databases

STRINGi 279010.BL05111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU22817 ; AAU22817 ; BL05111 .
AAU40162 ; AAU40162 ; BLi01255 .
GeneIDi 3030258.
3098767.
KEGGi bld:BLi01255.
bli:BL05111.
PATRICi 18948083. VBIBacLic203714_1246.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000275803.
KOi K00858.
OMAi IQMSEIA.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci BLIC279010:GJ2P-1247-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  3. Berka R.M., Rey M.W., Ramaiya P.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 152.

Entry informationi

Entry nameiNADK1_BACLD
AccessioniPrimary (citable) accession number: Q65LA2
Secondary accession number(s): Q62WP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 25, 2004
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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