Q65LA2 (PPNK1_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase 1
Short name=Poly(P)/ATP NAD kinase 1
EC=2.7.1.23

Gene names

Name:	ppnK1
Ordered Locus Names:	BLi01255, BL05111

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Probable inorganic polyphosphate/ATP-NAD kinase 1 HAMAP MF_00361		PRO_0000229604

Sequences

	Sequence		Length	Mass (Da)
	Q65LA2 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 4BBC6CD6CD5EA750	FASTA	267	29,670
	10 20 30 40 50 60 MMKFAVSSKG NAVSDSLKSK IQTYLLDFGL ECDEEEPDIV ISVGGDGTLL YAFHKYSGRL 70 80 90 100 110 120 DKTAFVGVHT GHLGFYADWV PSEIEKLVIA IAKTPYQIVE YPVLEVIVRY NDGSDEARYL 130 140 150 160 170 180 ALNECTIKSI EGTLVTDVEI KGELFETFRG DGLCLSTPSG STAYNKALGG AIIHPSIRAI 190 200 210 220 230 240 QLAEMASINN RVFRTVGSPL ILPEHHTCLI KPINDVTFQV AIDHLTLLHK DVKSIQCRVA 250 260 NENIRFARFR PFPFWKRVQD SFIGKGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.
[2]	"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.
[3]	Berka R.M., Rey M.W., Ramaiya P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017333 Genomic DNA. Translation: AAU40162.1. CP000002 Genomic DNA. Translation: AAU22817.2.
RefSeq	YP_078455.2. NC_006270.3. YP_090855.1. NC_006322.1.
3D structure databases
ProteinModelPortal	Q65LA2.
SMR	Q65LA2. Positions 2-263.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65LA2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000058071; EBBACP00000056602; EBBACG00000058062. EBBACT00000059611; EBBACP00000058044; EBBACG00000059602.
GeneID	3030258. 3098767.
GenomeReviews	Gene locus BLi01255 in contig AE017333_GR. Gene locus BL05111 in contig CP000002_GR.
KEGG	bld:BLi01255. bli:BL05111.
NMPDR	fig|279010.5.peg.2472.
PATRIC	18948083. VBIBacLic203714_1246.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
GeneTree	EBGT00050000002705.
HOGENOM	HBG314020.
PhylomeDB	Q65LA2.
ProtClustDB	PRK04885.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI01255-MONOMER. BLIC279010:BL05111-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK1_BACLD

Accession

Primary (citable) accession number: Q65LA2
Secondary accession number(s): Q62WP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program