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Q65LA2

- NADK1_BACLD

UniProt

Q65LA2 - NADK1_BACLD

Protein

NAD kinase 1

Gene

nadK1

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei46 – 461Proton acceptorUniRule annotation
    Binding sitei149 – 1491NADUniRule annotation
    Binding sitei151 – 1511NADUniRule annotation
    Binding sitei186 – 1861NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi46 – 472NADUniRule annotation
    Nucleotide bindingi123 – 1242NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBLIC279010:GJ2P-1247-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinase 1UniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinase 1UniRule annotation
    Gene namesi
    Name:nadK1UniRule annotation
    Ordered Locus Names:BLi01255, BL05111
    OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
    Taxonomic identifieri279010 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267NAD kinase 1PRO_0000229604Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi279010.BL05111.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65LA2.
    SMRiQ65LA2. Positions 2-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000275803.
    KOiK00858.
    OMAiIQMSEIA.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q65LA2-1 [UniParc]FASTAAdd to Basket

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    MMKFAVSSKG NAVSDSLKSK IQTYLLDFGL ECDEEEPDIV ISVGGDGTLL    50
    YAFHKYSGRL DKTAFVGVHT GHLGFYADWV PSEIEKLVIA IAKTPYQIVE 100
    YPVLEVIVRY NDGSDEARYL ALNECTIKSI EGTLVTDVEI KGELFETFRG 150
    DGLCLSTPSG STAYNKALGG AIIHPSIRAI QLAEMASINN RVFRTVGSPL 200
    ILPEHHTCLI KPINDVTFQV AIDHLTLLHK DVKSIQCRVA NENIRFARFR 250
    PFPFWKRVQD SFIGKGE 267
    Length:267
    Mass (Da):29,670
    Last modified:October 25, 2004 - v1
    Checksum:i4BBC6CD6CD5EA750
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017333 Genomic DNA. Translation: AAU40162.1.
    CP000002 Genomic DNA. Translation: AAU22817.2.
    RefSeqiYP_006712636.1. NC_006322.1.
    YP_078455.2. NC_006270.3.

    Genome annotation databases

    EnsemblBacteriaiAAU22817; AAU22817; BL05111.
    AAU40162; AAU40162; BLi01255.
    GeneIDi3030258.
    3098767.
    KEGGibld:BLi01255.
    bli:BL05111.
    PATRICi18948083. VBIBacLic203714_1246.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017333 Genomic DNA. Translation: AAU40162.1 .
    CP000002 Genomic DNA. Translation: AAU22817.2 .
    RefSeqi YP_006712636.1. NC_006322.1.
    YP_078455.2. NC_006270.3.

    3D structure databases

    ProteinModelPortali Q65LA2.
    SMRi Q65LA2. Positions 2-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 279010.BL05111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU22817 ; AAU22817 ; BL05111 .
    AAU40162 ; AAU40162 ; BLi01255 .
    GeneIDi 3030258.
    3098767.
    KEGGi bld:BLi01255.
    bli:BL05111.
    PATRICi 18948083. VBIBacLic203714_1246.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000275803.
    KOi K00858.
    OMAi IQMSEIA.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci BLIC279010:GJ2P-1247-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
      Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
      J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.
    3. Berka R.M., Rey M.W., Ramaiya P.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 152.

    Entry informationi

    Entry nameiNADK1_BACLD
    AccessioniPrimary (citable) accession number: Q65LA2
    Secondary accession number(s): Q62WP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3