Q65JZ9 (COAD_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphopantetheine adenylyltransferase
EC=2.7.7.3

Alternative name(s):
Dephospho-CoA pyrophosphorylase
Pantetheine-phosphate adenylyltransferase
Short name=PPAT

Gene names

Name:	coaD
Ordered Locus Names:	BLi01719, BL02991

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity. HAMAP MF_00151
Catalytic activity	ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. HAMAP MF_00151
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. HAMAP MF_00151
Subunit structure	Homohexamer By similarity. HAMAP MF_00151
Subcellular location	Cytoplasm By similarity HAMAP MF_00151.
Sequence similarities	Belongs to the bacterial CoaD family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantetheine-phosphate adenylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 164	164	Phosphopantetheine adenylyltransferase HAMAP MF_00151		PRO_1000011094

Sequences

	Sequence		Length	Mass (Da)
	Q65JZ9 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 35830659CEB1D916	FASTA	164	18,368
	10 20 30 40 50 60 MASIAVCPGS FDPVTFGHLD IIRRGAKVFD KVYVCVLNNS SKKPLFTVEE RCGLLREVTQ 70 80 90 100 110 120 DIPNVQVESF QGLLIDYAKS KQANVILRGL RAVSDFEYEM QGTSMNKVLD ENIETFFMMT 130 140 150 160 NNQYSFLSSS IVKEVAKYKG SVAELVPEAV EAALEKKFAK NERP

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000002 Genomic DNA. Translation: AAU23258.1. AE017333 Genomic DNA. Translation: AAU40615.1.
RefSeq	YP_078896.1. NC_006270.3. YP_091308.1. NC_006322.1.
3D structure databases
HSSP	HSSP built from PDB template 1O6B based on UniProtKB O34797.
ProteinModelPortal	Q65JZ9.
SMR	Q65JZ9. Positions 2-158.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65JZ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000056700; EBBACP00000055231; EBBACG00000056691. EBBACT00000061467; EBBACP00000059900; EBBACG00000061458.
GeneID	3030863. 3100218.
GenomeReviews	Gene locus BLi01719 in contig AE017333_GR. Gene locus BL02991 in contig CP000002_GR.
KEGG	bld:BLi01719. bli:BL02991.
NMPDR	fig|279010.5.peg.1567.
PATRIC	18949035. VBIBacLic203714_1721.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0669.
GeneTree	EBGT00050000002538.
HOGENOM	HBG288308.
OMA	AMSDFEY.
PhylomeDB	Q65JZ9.
ProtClustDB	PRK00168.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI01719-MONOMER. BLIC279010:BL02991-MONOMER.
Family and domain databases
HAMAP	MF_00151. PPAT_bact. [Tree]
InterPro	IPR004821. Cyt_trans-rel. IPR004820. Cytidylyltransf. IPR001980. LPS_biosynth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K00954.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
PRINTS	PR01020. LPSBIOSNTHSS.
TIGRFAMs	TIGR01510. CoaD_prev_kdtB. 1 hit. TIGR00125. Cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAD_BACLD

Accession

Primary (citable) accession number: Q65JZ9
Secondary accession number(s): Q62VF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program