Reviewed, UniProtKB/Swiss-Prot Q65JV0 (PYRB_BACLD)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BLi01769, BL02273

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Aspartate carbamoyltransferase		PRO_0000113097

Sequences

	Sequence		Length	Mass (Da)
	Q65JV0-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: BB2BC44134F86D26	FASTA	306	34,264
	10 20 30 40 50 60 MKHLTAMNEL SLEDIHELIE EARELKKGKS DSVLSGKFAA NLFFEPSTRT RFSFEVAEKK 70 80 90 100 110 120 LGMNVLNLDG VSTSVQKGES LYDTVKTLES IGADVCVIRH SHDHYYDELI GHVGIPVINA 130 140 150 160 170 180 GDGCGQHPTQ SLLDLMTIHE EWGRFAGLTV SIHGDIKHSR VARSNAEVLT RLGAKVLFSG 190 200 210 220 230 240 PDEWRDEDNP YGTYVSPDEA VAHSDVVMLL RIQHERHEKK AAERDYLETF GLSLKRAELL 250 260 270 280 290 300 KKDAVIMHPA PVNRGVEIDS ALVESGRSRI FKQMENGVYI RMAVLKRALL NGENKKRGDQ AYVLFN

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:RESEARCH077.1-RESEARCH077.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017333 Genomic DNA. Translation: AAU40664.1. CP000002 Genomic DNA. Translation: AAU23304.1.
RefSeq	YP_078942.1. YP_091357.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3030919. 3097708.
GenomeReviews	Gene locus BL02273 in contig CP000002_GR. Gene locus BLi01769 in contig AE017333_GR.
KEGG	bld:BLi01769. bli:BL02273.
NMPDR	fig|279010.5.peg.1711.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q65JV0.
Enzyme and pathway databases
BioCyc	BLIC279010:BL02273-MON.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006130. Asp/Orn_carbamoyltranf. IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BACLD

Accession

Primary (citable) accession number: Q65JV0
Secondary accession number(s): Q62VA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	October 25, 2004
Last modified:	November 25, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)