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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei173UniRule annotation1
Active sitei200UniRule annotation1
Active sitei296UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:BLi01863, BL01251
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002254421 – 357Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei544-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi01863.

Structurei

3D structure databases

ProteinModelPortaliQ65JK6.
SMRiQ65JK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 120Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini161 – 355CheB-type methylesteraseUniRule annotationAdd BLAST195

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiMLEMHRA.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65JK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRVLVVDDS AFMRNMITKF LTSNHEIAVA GTARNGEEAL QKIKELRPDV
60 70 80 90 100
ITLDIEMPVM NGKETLKRIM ASDPLPVVMV SSLTQQGADI TIECLELGAI
110 120 130 140 150
DFVAKPSGSI SIDLYKVRDM LIEKVLTAGR VKLKGRQVPI SKPAIETAKQ
160 170 180 190 200
PIVGGSDSVR FRAGKQLICI GTSTGGPRAL QRVLPKLPKT LKAPVFIVQH
210 220 230 240 250
MPKGFTASLA NRLNHLSEVT VKEAENGERA KDGWVYIAPG GKNMAVGLEK
260 270 280 290 300
GELVITLDDR DTESRHKPSV DYLFQSLASL REFEKIAVIM TGMGSDGTEG
310 320 330 340 350
VKGLLKHGSG TVIAEAAESS VVFGMPKSVI NNGLANDIKH VDEIAAAIMT

YMKKERA
Length:357
Mass (Da):38,628
Last modified:October 25, 2004 - v1
Checksum:i1B4F2C5FC9B215E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU40758.1.
CP000002 Genomic DNA. Translation: AAU23398.1.
RefSeqiWP_003181813.1. NC_006322.1.

Genome annotation databases

EnsemblBacteriaiAAU23398; AAU23398; BL01251.
AAU40758; AAU40758; BLi01863.
GeneIDi3031051.
KEGGibld:BLi01863.
bli:BL01251.

Similar proteinsi

Entry informationi

Entry nameiCHEB_BACLD
AccessioniPrimary (citable) accession number: Q65JK6
Secondary accession number(s): Q62V11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 25, 2004
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome