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Protein
Submitted name:

Dihydrodipicolinate synthase

Gene

dapA

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).SAAS annotation

Catalytic activityi

Pyruvate + L-aspartate-4-semialdehyde = (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate + H2O.SAAS annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 3 of the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate.SAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Aspartokinase (dapG), Aspartokinase (yclM), Aspartokinase (lysC)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Dihydrodipicolinate synthase (dapA), 4-hydroxy-tetrahydrodipicolinate synthase (BL03431), 4-hydroxy-tetrahydrodipicolinate synthase (BL00719)
  4. 4-hydroxy-tetrahydrodipicolinate reductase (dapB)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesisSAAS annotation, Lysine biosynthesisSAAS annotation

Keywords - Ligandi

Schiff baseSAAS annotation

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-1887-MONOMER.
MetaCyc:MONOMER-6565.
UniPathwayiUPA00034; UER00017.

Names & Taxonomyi

Protein namesi
Submitted name:
Dihydrodipicolinate synthaseImported
Gene namesi
Name:dapAImported
Ordered Locus Names:BL01208Imported
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)Imported
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi01902.

Structurei

3D structure databases

ProteinModelPortaliQ65JG7.
SMRiQ65JG7. Positions 1-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDP. Bacteria.
COG0329. LUCA.
HOGENOMiHOG000173604.
KOiK01714.
OMAiHIAGSDM.
OrthoDBiEOG6W7235.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00418. DapA.
InterProiIPR013785. Aldolase_TIM.
IPR005263. DapA.
IPR002220. DapA-like.
IPR020625. Schiff_base-form_aldolases_AS.
IPR020624. Schiff_base-form_aldolases_CS.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.
TIGRFAMsiTIGR00674. dapA. 1 hit.
PROSITEiPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65JG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFGNIATAM VTPFDKNENI DFQKLSKLID YLLNNGTDSL VVAGTTGESP
60 70 80 90 100
TLSEEEKVAL IQYSVKEAAG RAPIIAGTGS NNTKASIKLT KKAEEAGADA
110 120 130 140 150
VMLVTPYYNK PSQEGMYRHF RAIAEETSLP VMLYNVPGRT AASLAPETTI
160 170 180 190 200
RLAEIPNIIA IKEASGDLDA ITKIVAETPE DFAVYSGDDS LTLPALSVGA
210 220 230 240 250
RGIVSVASHI IGPEMQEMIK HYTEGNTAQA ALIHQKLLPL MKGLFAAPNP
260 270 280
SPLKTALQLK GLDVGSVRLP LIPLNEDERL RLSSLMNGL
Length:289
Mass (Da):30,917
Last modified:October 25, 2004 - v1
Checksum:i56AC182E3E53BEE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU23437.2.
RefSeqiWP_003181896.1. NC_006322.1.

Genome annotation databases

EnsemblBacteriaiAAU23437; AAU23437; BL01208.
GeneIDi3031112.
KEGGibli:BL01208.
PATRICi18949407. VBIBacLic203714_1907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU23437.2.
RefSeqiWP_003181896.1. NC_006322.1.

3D structure databases

ProteinModelPortaliQ65JG7.
SMRiQ65JG7. Positions 1-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BLi01902.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU23437; AAU23437; BL01208.
GeneIDi3031112.
KEGGibli:BL01208.
PATRICi18949407. VBIBacLic203714_1907.

Phylogenomic databases

eggNOGiENOG4105CDP. Bacteria.
COG0329. LUCA.
HOGENOMiHOG000173604.
KOiK01714.
OMAiHIAGSDM.
OrthoDBiEOG6W7235.

Enzyme and pathway databases

UniPathwayiUPA00034; UER00017.
BioCyciBLIC279010:GJ2P-1887-MONOMER.
MetaCyc:MONOMER-6565.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00418. DapA.
InterProiIPR013785. Aldolase_TIM.
IPR005263. DapA.
IPR002220. DapA-like.
IPR020625. Schiff_base-form_aldolases_AS.
IPR020624. Schiff_base-form_aldolases_CS.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.
TIGRFAMsiTIGR00674. dapA. 1 hit.
PROSITEiPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46Imported.

Entry informationi

Entry nameiQ65JG7_BACLD
AccessioniPrimary (citable) accession number: Q65JG7
Secondary accession number(s): Q62UX2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: March 16, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.