Q65J10 (ARAA2_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase 2
EC=5.3.1.4

Gene names

Name:	araA2
Ordered Locus Names:	BLi02064, BL01182

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	L-arabinose isomerase 2 HAMAP MF_00519		PRO_0000259336
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	331	1	Manganese By similarity
	Metal binding	348	1	Manganese By similarity
	Metal binding	447	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65J10 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 5E71CCA0E52176EE	FASTA	474	53,505
	10 20 30 40 50 60 MLTTGKKEFW FVVGSQHLYG EETLAEVRAH AQAMTDALNE SAVLPYPLVL QDLAVNADKI 70 80 90 100 110 120 TSIMKEVNYR DEVAGVITWM HTFSPAKMWI RGTKLLQKPL LHLATQFNES IPWPTIDMDF 130 140 150 160 170 180 MNLNQSAHGD REYGFINARL KKQNKVVVGY WERPEVQQQI AEWMDVAVAY NESFNIKVAR 190 200 210 220 230 240 FGDNMRNVAV TEGDKIEAQI QFGWTVDYFG IGDLVQYVNA VTDEEINRLF AEYADLYEFD 250 260 270 280 290 300 YGTYSREDWE KSVKVQASYE IAIKRFLDDG GYNAFTTNFE DLYGMKQLPG LAVQRLMAQG 310 320 330 340 350 360 YGFAGEGDWK TAALDRLLKV MSRNQSTGFM EDYTYELAAG QESILQSHML EVDPSLASNK 370 380 390 400 410 420 PKIIVSPLGI GDREDPARLV FDGKAGDGVV VSMADFGTHY KLLINEVSAF EPTVPAPNLP 430 440 450 460 470 VARVLWEVKP NFQDGVKAWL ENGGGHHTVV SLFLTTDQMI TYAKLVDLEY VVIK

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017333 Genomic DNA. Translation: AAU40954.1. CP000002 Genomic DNA. Translation: AAU23592.1.
RefSeq	YP_079230.1. NC_006270.3. YP_091647.1. NC_006322.1.
3D structure databases
HSSP	HSSP built from PDB template 2AJT based on UniProtKB P08202.
ProteinModelPortal	Q65J10.
SMR	Q65J10. Positions 1-474.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65J10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000056396; EBBACP00000054927; EBBACG00000056387. EBBACT00000058500; EBBACP00000056933; EBBACG00000058491.
GeneID	3031327. 3101457.
GenomeReviews	Gene locus BLi02064 in contig AE017333_GR. Gene locus BL01182 in contig CP000002_GR.
KEGG	bld:BLi02064. bli:BL01182.
NMPDR	fig|279010.5.peg.2763.
PATRIC	18949743. VBIBacLic203714_2075.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2160.
GeneTree	EBGT00050000001793.
HOGENOM	HBG297198.
OMA	DVAVAYN.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI02064-MONOMER. BLIC279010:BL01182-MONOMER.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. Divergent sequence. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA2_BACLD

Accession

Primary (citable) accession number: Q65J10
Secondary accession number(s): Q62UG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program