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Q65IV4

- ARSC_BACLD

UniProt

Q65IV4 - ARSC_BACLD

Protein

Protein ArsC

Gene

arsC

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.UniRule annotation

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
    Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei10 – 101Nucleophile; for reductase activity and phosphatase activityUniRule annotation
    Active sitei82 – 821Nucleophile; for reductase activityUniRule annotation
    Active sitei89 – 891Nucleophile; for reductase activityUniRule annotation

    GO - Molecular functioni

    1. arsenate reductase (thioredoxin) activity Source: UniProtKB-HAMAP
    2. protein tyrosine phosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. response to arsenic-containing substance Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Oxidoreductase

    Keywords - Biological processi

    Arsenical resistance

    Enzyme and pathway databases

    BioCyciBLIC279010:GJ2P-2105-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ArsCUniRule annotation
    Alternative name(s):
    Arsenate reductaseUniRule annotation (EC:1.20.4.-UniRule annotation)
    Arsenical pump modifierUniRule annotation
    Low molecular weight protein-tyrosine-phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
    Gene namesi
    Name:arsCUniRule annotation
    Ordered Locus Names:BLi02122, BL01871
    OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
    Taxonomic identifieri279010 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 139139Protein ArsCPRO_0000162518Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi10 ↔ 82Redox-active; alternateUniRule annotation
    Disulfide bondi82 ↔ 89Redox-active; alternateUniRule annotation

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi279010.BL01871.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65IV4.
    SMRiQ65IV4. Positions 1-139.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.UniRule annotation

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG0394.
    HOGENOMiHOG000273093.
    KOiK03741.
    OMAiGDRYEAY.
    OrthoDBiEOG6JDWJC.

    Family and domain databases

    HAMAPiMF_01624. Arsenate_reduct.
    InterProiIPR014064. Arsenate_reductase_ArsC.
    IPR023485. Ptyr_pPase_SF.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view]
    PANTHERiPTHR11717. PTHR11717. 1 hit.
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.
    TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q65IV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKKTIYFLC TGNSCRSQMA EGWAKKHLGD EWNVYSAGIE AHGLNPNAVK    50
    AMREAGIDIS EQTSDIIDPD ILHNADLVIT LCGDAADKCP MTPPHVKREH 100
    WGFDDPAKAE GTEEEKWAFF QRVRDEIGER IKRFAETGE 139
    Length:139
    Mass (Da):15,593
    Last modified:October 25, 2004 - v1
    Checksum:i0127E65009EF11A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017333 Genomic DNA. Translation: AAU41010.1.
    CP000002 Genomic DNA. Translation: AAU23647.1.
    RefSeqiYP_006713488.1. NC_006322.1.
    YP_079285.1. NC_006270.3.

    Genome annotation databases

    EnsemblBacteriaiAAU23647; AAU23647; BL01871.
    AAU41010; AAU41010; BLi02122.
    GeneIDi3031404.
    3099922.
    KEGGibld:BLi02122.
    bli:BL01871.
    PATRICi18949861. VBIBacLic203714_2134.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017333 Genomic DNA. Translation: AAU41010.1 .
    CP000002 Genomic DNA. Translation: AAU23647.1 .
    RefSeqi YP_006713488.1. NC_006322.1.
    YP_079285.1. NC_006270.3.

    3D structure databases

    ProteinModelPortali Q65IV4.
    SMRi Q65IV4. Positions 1-139.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 279010.BL01871.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU23647 ; AAU23647 ; BL01871 .
    AAU41010 ; AAU41010 ; BLi02122 .
    GeneIDi 3031404.
    3099922.
    KEGGi bld:BLi02122.
    bli:BL01871.
    PATRICi 18949861. VBIBacLic203714_2134.

    Phylogenomic databases

    eggNOGi COG0394.
    HOGENOMi HOG000273093.
    KOi K03741.
    OMAi GDRYEAY.
    OrthoDBi EOG6JDWJC.

    Enzyme and pathway databases

    BioCyci BLIC279010:GJ2P-2105-MONOMER.

    Family and domain databases

    HAMAPi MF_01624. Arsenate_reduct.
    InterProi IPR014064. Arsenate_reductase_ArsC.
    IPR023485. Ptyr_pPase_SF.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view ]
    PANTHERi PTHR11717. PTHR11717. 1 hit.
    Pfami PF01451. LMWPc. 1 hit.
    [Graphical view ]
    SMARTi SM00226. LMWPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    TIGRFAMsi TIGR02691. arsC_pI258_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
      Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
      J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.

    Entry informationi

    Entry nameiARSC_BACLD
    AccessioniPrimary (citable) accession number: Q65IV4
    Secondary accession number(s): Q62UB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3