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Q65IV4

- ARSC_BACLD

UniProt

Q65IV4 - ARSC_BACLD

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Protein

Protein ArsC

Gene

arsC

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.UniRule annotation

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101Nucleophile; for reductase activity and phosphatase activityUniRule annotation
Active sitei82 – 821Nucleophile; for reductase activityUniRule annotation
Active sitei89 – 891Nucleophile; for reductase activityUniRule annotation

GO - Molecular functioni

  1. arsenate reductase (thioredoxin) activity Source: UniProtKB-HAMAP
  2. protein tyrosine phosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. response to arsenic-containing substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Arsenical resistance

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-2105-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ArsCUniRule annotation
Alternative name(s):
Arsenate reductaseUniRule annotation (EC:1.20.4.-UniRule annotation)
Arsenical pump modifierUniRule annotation
Low molecular weight protein-tyrosine-phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:arsCUniRule annotation
Ordered Locus Names:BLi02122, BL01871
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139Protein ArsCPRO_0000162518Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi10 ↔ 82Redox-active; alternateUniRule annotation
Disulfide bondi82 ↔ 89Redox-active; alternateUniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi279010.BL01871.

Structurei

3D structure databases

ProteinModelPortaliQ65IV4.
SMRiQ65IV4. Positions 1-139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273093.
KOiK03741.
OMAiGDRYEAY.
OrthoDBiEOG6JDWJC.

Family and domain databases

HAMAPiMF_01624. Arsenate_reduct.
InterProiIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF18. PTHR11717:SF18. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65IV4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKKTIYFLC TGNSCRSQMA EGWAKKHLGD EWNVYSAGIE AHGLNPNAVK
60 70 80 90 100
AMREAGIDIS EQTSDIIDPD ILHNADLVIT LCGDAADKCP MTPPHVKREH
110 120 130
WGFDDPAKAE GTEEEKWAFF QRVRDEIGER IKRFAETGE
Length:139
Mass (Da):15,593
Last modified:October 25, 2004 - v1
Checksum:i0127E65009EF11A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU41010.1.
CP000002 Genomic DNA. Translation: AAU23647.1.
RefSeqiYP_006713488.1. NC_006322.1.
YP_079285.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU23647; AAU23647; BL01871.
AAU41010; AAU41010; BLi02122.
GeneIDi3031404.
3099922.
KEGGibld:BLi02122.
bli:BL01871.
PATRICi18949861. VBIBacLic203714_2134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU41010.1 .
CP000002 Genomic DNA. Translation: AAU23647.1 .
RefSeqi YP_006713488.1. NC_006322.1.
YP_079285.1. NC_006270.3.

3D structure databases

ProteinModelPortali Q65IV4.
SMRi Q65IV4. Positions 1-139.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279010.BL01871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU23647 ; AAU23647 ; BL01871 .
AAU41010 ; AAU41010 ; BLi02122 .
GeneIDi 3031404.
3099922.
KEGGi bld:BLi02122.
bli:BL01871.
PATRICi 18949861. VBIBacLic203714_2134.

Phylogenomic databases

eggNOGi COG0394.
HOGENOMi HOG000273093.
KOi K03741.
OMAi GDRYEAY.
OrthoDBi EOG6JDWJC.

Enzyme and pathway databases

BioCyci BLIC279010:GJ2P-2105-MONOMER.

Family and domain databases

HAMAPi MF_01624. Arsenate_reduct.
InterProi IPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717:SF18. PTHR11717:SF18. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
TIGRFAMsi TIGR02691. arsC_pI258_fam. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiARSC_BACLD
AccessioniPrimary (citable) accession number: Q65IV4
Secondary accession number(s): Q62UB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 25, 2004
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3