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Protein

Arsenate reductase

Gene

arsC

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].UniRule annotation

Catalytic activityi

Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10NucleophileUniRule annotation1
Active sitei82NucleophileUniRule annotation1
Active sitei89NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processArsenical resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenate reductaseUniRule annotation (EC:1.20.4.4UniRule annotation)
Gene namesi
Name:arsCUniRule annotation
Ordered Locus Names:BLi02122, BL01871
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625181 – 139Arsenate reductaseAdd BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi10 ↔ 82Redox-active; alternateUniRule annotation
Disulfide bondi82 ↔ 89Redox-active; alternateUniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi02122.

Structurei

3D structure databases

ProteinModelPortaliQ65IV4.
SMRiQ65IV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4108UXE. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273093.
KOiK03741.
OMAiCSHADSV.

Family and domain databases

HAMAPiMF_01624. Arsenate_reduct. 1 hit.
InterProiView protein in InterPro
IPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase.
IPR036196. Ptyr_pPase_sf.
PfamiView protein in Pfam
PF01451. LMWPc. 1 hit.
SMARTiView protein in SMART
SM00226. LMWPc. 1 hit.
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65IV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKTIYFLC TGNSCRSQMA EGWAKKHLGD EWNVYSAGIE AHGLNPNAVK
60 70 80 90 100
AMREAGIDIS EQTSDIIDPD ILHNADLVIT LCGDAADKCP MTPPHVKREH
110 120 130
WGFDDPAKAE GTEEEKWAFF QRVRDEIGER IKRFAETGE
Length:139
Mass (Da):15,593
Last modified:October 25, 2004 - v1
Checksum:i0127E65009EF11A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU41010.1.
CP000002 Genomic DNA. Translation: AAU23647.1.
RefSeqiWP_003182412.1. NC_006322.1.

Genome annotation databases

EnsemblBacteriaiAAU23647; AAU23647; BL01871.
AAU41010; AAU41010; BLi02122.
GeneIDi3031404.
KEGGibld:BLi02122.
bli:BL01871.

Similar proteinsi

Entry informationi

Entry nameiARSC_BACLD
AccessioniPrimary (citable) accession number: Q65IV4
Secondary accession number(s): Q62UB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 25, 2004
Last modified: October 25, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families