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Q65IS8

- PROB2_BACLD

UniProt

Q65IS8 - PROB2_BACLD

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Protein

Glutamate 5-kinase 2

Gene
proB2, BLi02149, BL01983
Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111ATP By similarity
Binding sitei51 – 511Substrate By similarity
Binding sitei138 – 1381Substrate By similarity
Binding sitei150 – 1501Substrate; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi170 – 1712ATP By similarity
Nucleotide bindingi212 – 2187ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate 5-kinase activity Source: UniProtKB-HAMAP
  3. RNA binding Source: InterPro

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-2132-MONOMER.
UniPathwayiUPA00098; UER00359.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinase 2 (EC:2.7.2.11)
Alternative name(s):
Gamma-glutamyl kinase 2
Short name:
GK 2
Gene namesi
Name:proB2
Ordered Locus Names:BLi02149, BL01983
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Glutamate 5-kinase 2UniRule annotationPRO_0000109639Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BL01983.

Structurei

3D structure databases

ProteinModelPortaliQ65IS8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini279 – 35577PUAAdd
BLAST

Sequence similaritiesi

Contains 1 PUA domain.

Phylogenomic databases

eggNOGiCOG0263.
HOGENOMiHOG000246369.
KOiK00931.
OMAiCSENEET.
OrthoDBiEOG6PGK7G.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65IS8-1 [UniParc]FASTAAdd to Basket

« Hide

MTSNQQRVVV KVGSSSLTSL HGEISSKKLE KLVEQIVRLK DEGHEVLLVS    50
SGAVAAGYRK LGFINRPDTL PEKQASASVG QGLLIEAYSK LFLSHGYIAS 100
QILITKSDFS DEKRYNNVRN TMNVLLKRGI IPIINENDTV TVNRLKFGDN 150
DTLSAKVAGL IDADLLTILS DIDGLYDANP RKTPDAALVQ EVTEITPEIE 200
ASAGDAGSEV GTGGMKSKLD AFKITMASGI KGFLGRADTP GILHEAICGT 250
ARGTYFIPNA DSHALNHKKQ WIAFNSGPEG DIVVHNESKE FIIDRKKSLY 300
PSSIYDINGR FSNGSVVRIL DQEGEEIGLG VVNFSSSQLR KWKKDTNQET 350
AASSQAVVDR EAFVCHLELS VPL 373
Length:373
Mass (Da):40,474
Last modified:October 25, 2004 - v1
Checksum:i3CBEEF1390AED762
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU41036.1.
CP000002 Genomic DNA. Translation: AAU23674.1.
RefSeqiYP_006713514.1. NC_006322.1.
YP_079312.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU23674; AAU23674; BL01983.
AAU41036; AAU41036; BLi02149.
GeneIDi3031438.
3100671.
KEGGibld:BLi02149.
bli:BL01983.
PATRICi18949915. VBIBacLic203714_2161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU41036.1 .
CP000002 Genomic DNA. Translation: AAU23674.1 .
RefSeqi YP_006713514.1. NC_006322.1.
YP_079312.1. NC_006270.3.

3D structure databases

ProteinModelPortali Q65IS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279010.BL01983.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU23674 ; AAU23674 ; BL01983 .
AAU41036 ; AAU41036 ; BLi02149 .
GeneIDi 3031438.
3100671.
KEGGi bld:BLi02149.
bli:BL01983.
PATRICi 18949915. VBIBacLic203714_2161.

Phylogenomic databases

eggNOGi COG0263.
HOGENOMi HOG000246369.
KOi K00931.
OMAi CSENEET.
OrthoDBi EOG6PGK7G.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00359 .
BioCyci BLIC279010:GJ2P-2132-MONOMER.

Family and domain databases

Gene3Di 2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPi MF_00456. ProB.
InterProi IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view ]
PIRSFi PIRSF000729. GK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SMARTi SM00359. PUA. 1 hit.
[Graphical view ]
SUPFAMi SSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsi TIGR01027. proB. 1 hit.
PROSITEi PS50890. PUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiPROB2_BACLD
AccessioniPrimary (citable) accession number: Q65IS8
Secondary accession number(s): Q62U85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 25, 2004
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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