Q65ID1 (MSRA_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	BLi02303, BL01421

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_1000068310
Sites
	Active site	14	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65ID1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 2AC49AEE0842B3C9	FASTA	181	21,007
	10 20 30 40 50 60 MAEKRELATF AGGCFWCMVK PFDEQPGILK VESGYTGGHT ENPTYEEVCS NTTGHREAVQ 70 80 90 100 110 120 ITFDPDVFPY EKLLELYWQQ IDPTDSGGQF TDRGESYRTA IFYHNDKQRK LAEESKKKLG 130 140 150 160 170 180 ESGIFKDPIA TDILEAGPFY PAEEYHQDYH KKHPERYTQY RIGSGREGFL QQHWGRKHDE Q

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000002 Genomic DNA. Translation: AAU23827.2. AE017333 Genomic DNA. Translation: AAU41183.1.
RefSeq	YP_079465.2. NC_006270.3. YP_091876.1. NC_006322.1.
3D structure databases
HSSP	HSSP built from PDB template 1FF3 based on UniProtKB P0A744.
ProteinModelPortal	Q65ID1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65ID1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000056382; EBBACP00000054913; EBBACG00000056373. EBBACT00000062287; EBBACP00000060720; EBBACG00000062278.
GeneID	3028308. 3101335.
GenomeReviews	Gene locus BLi02303 in contig AE017333_GR. Gene locus BL01421 in contig CP000002_GR.
KEGG	bld:BLi02303. bli:BL01421.
NMPDR	fig|279010.5.peg.154.
PATRIC	18950254. VBIBacLic203714_2329.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
GeneTree	EBGT00050000000580.
HOGENOM	HBG748152.
ProtClustDB	PRK14054.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI02303-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_BACLD

Accession

Primary (citable) accession number: Q65ID1
Secondary accession number(s): Q62TT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program