SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q65IA6

- FTHS_BACLD

UniProt

Q65IA6 - FTHS_BACLD

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Formate--tetrahydrofolate ligase
Gene
fhs, BLi02328, BL01370
Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-2314-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:BLi02328, BL01370
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199331Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BL01370.

Structurei

3D structure databases

ProteinModelPortaliQ65IA6.
SMRiQ65IA6. Positions 7-557.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65IA6-1 [UniParc]FASTAAdd to Basket

« Hide

MKSHLSDIEI AQRTELKPIT EIARKLNIND EEIECFGCTK AKISLKIFER    50
LKEKPDGQVI LVTSINPTPA GEGKSTVTVG LSQALWQIGK KSIVAMREPS 100
LGPTMGLKGG AAGGGYSQVL PMEDINLHFT GDMHAITAAN NALAAFIDNH 150
IHQGNELNID IRKIVWKRAL DLNDRALRET VVGLGGKANG FPREDGFDIT 200
VASEIMAVLC LARDLADLKK RLASMIVAYT VDGQPVTAGM LGVQGALALL 250
LKDAIKPNLV QTVEGTPALV HGGPFANIAH GANSLIATKT AAKLADYVVT 300
EAGFGADLGA EKFMHIKTRA GGFTPGAVVI VATVRALKMH GGTPLADLKQ 350
KDLEALKRGI ANLAKHIETI DAFGLPYVVA VNRFVQDTED ELEAVLGWCR 400
DNGHPAALCN VWEEGGKGGT DLAREVIHVM EQKDNRFSYL YELTDSIEDK 450
LAKISRTVYG AEGVEFTEKA KKQLLELKKN GLDGLPVCVA KTQYSLSDDP 500
GKIGRPQDFS ITVRELKPSR GAGFIVALTG SILTMPGLPK HPAALKMDVD 550
ESGRAKGLF 559
Length:559
Mass (Da):59,961
Last modified:October 25, 2004 - v1
Checksum:i281A86AE4B83A19A
GO

Sequence cautioni

The sequence AAU23852.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU41208.1.
CP000002 Genomic DNA. Translation: AAU23852.1. Different initiation.
RefSeqiYP_006713689.1. NC_006322.1.
YP_079490.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU23852; AAU23852; BL01370.
AAU41208; AAU41208; BLi02328.
GeneIDi3028622.
3100294.
KEGGibld:BLi02328.
bli:BL01370.
PATRICi18950308. VBIBacLic203714_2356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU41208.1 .
CP000002 Genomic DNA. Translation: AAU23852.1 . Different initiation.
RefSeqi YP_006713689.1. NC_006322.1.
YP_079490.1. NC_006270.3.

3D structure databases

ProteinModelPortali Q65IA6.
SMRi Q65IA6. Positions 7-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279010.BL01370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU23852 ; AAU23852 ; BL01370 .
AAU41208 ; AAU41208 ; BLi02328 .
GeneIDi 3028622.
3100294.
KEGGi bld:BLi02328.
bli:BL01370.
PATRICi 18950308. VBIBacLic203714_2356.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci BLIC279010:GJ2P-2314-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiFTHS_BACLD
AccessioniPrimary (citable) accession number: Q65IA6
Secondary accession number(s): Q62TQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi