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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-2314-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:BLi02328, BL01370
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000199331Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi02328.

Structurei

3D structure databases

ProteinModelPortaliQ65IA6.
SMRiQ65IA6. Positions 7-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65IA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSHLSDIEI AQRTELKPIT EIARKLNIND EEIECFGCTK AKISLKIFER
60 70 80 90 100
LKEKPDGQVI LVTSINPTPA GEGKSTVTVG LSQALWQIGK KSIVAMREPS
110 120 130 140 150
LGPTMGLKGG AAGGGYSQVL PMEDINLHFT GDMHAITAAN NALAAFIDNH
160 170 180 190 200
IHQGNELNID IRKIVWKRAL DLNDRALRET VVGLGGKANG FPREDGFDIT
210 220 230 240 250
VASEIMAVLC LARDLADLKK RLASMIVAYT VDGQPVTAGM LGVQGALALL
260 270 280 290 300
LKDAIKPNLV QTVEGTPALV HGGPFANIAH GANSLIATKT AAKLADYVVT
310 320 330 340 350
EAGFGADLGA EKFMHIKTRA GGFTPGAVVI VATVRALKMH GGTPLADLKQ
360 370 380 390 400
KDLEALKRGI ANLAKHIETI DAFGLPYVVA VNRFVQDTED ELEAVLGWCR
410 420 430 440 450
DNGHPAALCN VWEEGGKGGT DLAREVIHVM EQKDNRFSYL YELTDSIEDK
460 470 480 490 500
LAKISRTVYG AEGVEFTEKA KKQLLELKKN GLDGLPVCVA KTQYSLSDDP
510 520 530 540 550
GKIGRPQDFS ITVRELKPSR GAGFIVALTG SILTMPGLPK HPAALKMDVD

ESGRAKGLF
Length:559
Mass (Da):59,961
Last modified:October 25, 2004 - v1
Checksum:i281A86AE4B83A19A
GO

Sequence cautioni

The sequence AAU23852.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU41208.1.
CP000002 Genomic DNA. Translation: AAU23852.1. Different initiation.
RefSeqiWP_003182828.1. NC_006270.3.
WP_011201679.1. NC_006322.1.
YP_006713689.1. NC_006322.1.
YP_079490.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU23852; AAU23852; BL01370.
AAU41208; AAU41208; BLi02328.
GeneIDi3028622.
KEGGibld:BLi02328.
bli:BL01370.
PATRICi18950308. VBIBacLic203714_2356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU41208.1.
CP000002 Genomic DNA. Translation: AAU23852.1. Different initiation.
RefSeqiWP_003182828.1. NC_006270.3.
WP_011201679.1. NC_006322.1.
YP_006713689.1. NC_006322.1.
YP_079490.1. NC_006270.3.

3D structure databases

ProteinModelPortaliQ65IA6.
SMRiQ65IA6. Positions 7-557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BLi02328.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU23852; AAU23852; BL01370.
AAU41208; AAU41208; BLi02328.
GeneIDi3028622.
KEGGibld:BLi02328.
bli:BL01370.
PATRICi18950308. VBIBacLic203714_2356.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciBLIC279010:GJ2P-2314-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46.

Entry informationi

Entry nameiFTHS_BACLD
AccessioniPrimary (citable) accession number: Q65IA6
Secondary accession number(s): Q62TQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 25, 2004
Last modified: June 24, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.