Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q65IA6

- FTHS_BACLD

UniProt

Q65IA6 - FTHS_BACLD

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 758ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBLIC279010:GJ2P-2314-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:BLi02328, BL01370
    OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
    Taxonomic identifieri279010 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000199331Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi279010.BL01370.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65IA6.
    SMRiQ65IA6. Positions 7-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q65IA6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSHLSDIEI AQRTELKPIT EIARKLNIND EEIECFGCTK AKISLKIFER    50
    LKEKPDGQVI LVTSINPTPA GEGKSTVTVG LSQALWQIGK KSIVAMREPS 100
    LGPTMGLKGG AAGGGYSQVL PMEDINLHFT GDMHAITAAN NALAAFIDNH 150
    IHQGNELNID IRKIVWKRAL DLNDRALRET VVGLGGKANG FPREDGFDIT 200
    VASEIMAVLC LARDLADLKK RLASMIVAYT VDGQPVTAGM LGVQGALALL 250
    LKDAIKPNLV QTVEGTPALV HGGPFANIAH GANSLIATKT AAKLADYVVT 300
    EAGFGADLGA EKFMHIKTRA GGFTPGAVVI VATVRALKMH GGTPLADLKQ 350
    KDLEALKRGI ANLAKHIETI DAFGLPYVVA VNRFVQDTED ELEAVLGWCR 400
    DNGHPAALCN VWEEGGKGGT DLAREVIHVM EQKDNRFSYL YELTDSIEDK 450
    LAKISRTVYG AEGVEFTEKA KKQLLELKKN GLDGLPVCVA KTQYSLSDDP 500
    GKIGRPQDFS ITVRELKPSR GAGFIVALTG SILTMPGLPK HPAALKMDVD 550
    ESGRAKGLF 559
    Length:559
    Mass (Da):59,961
    Last modified:October 25, 2004 - v1
    Checksum:i281A86AE4B83A19A
    GO

    Sequence cautioni

    The sequence AAU23852.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017333 Genomic DNA. Translation: AAU41208.1.
    CP000002 Genomic DNA. Translation: AAU23852.1. Different initiation.
    RefSeqiYP_006713689.1. NC_006322.1.
    YP_079490.1. NC_006270.3.

    Genome annotation databases

    EnsemblBacteriaiAAU23852; AAU23852; BL01370.
    AAU41208; AAU41208; BLi02328.
    GeneIDi3028622.
    3100294.
    KEGGibld:BLi02328.
    bli:BL01370.
    PATRICi18950308. VBIBacLic203714_2356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017333 Genomic DNA. Translation: AAU41208.1 .
    CP000002 Genomic DNA. Translation: AAU23852.1 . Different initiation.
    RefSeqi YP_006713689.1. NC_006322.1.
    YP_079490.1. NC_006270.3.

    3D structure databases

    ProteinModelPortali Q65IA6.
    SMRi Q65IA6. Positions 7-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 279010.BL01370.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU23852 ; AAU23852 ; BL01370 .
    AAU41208 ; AAU41208 ; BLi02328 .
    GeneIDi 3028622.
    3100294.
    KEGGi bld:BLi02328.
    bli:BL01370.
    PATRICi 18950308. VBIBacLic203714_2356.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci BLIC279010:GJ2P-2314-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
      Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
      J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.

    Entry informationi

    Entry nameiFTHS_BACLD
    AccessioniPrimary (citable) accession number: Q65IA6
    Secondary accession number(s): Q62TQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3