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Protein

Processive diacylglycerol beta-glucosyltransferase

Gene

ugtP

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA).UniRule annotation

Catalytic activityi

UDP-alpha-D-glucose + 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol = 1,2-diacyl-3-O-(beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl)-sn-glycerol + UDP.
UDP-alpha-D-glucose + 1,2-diacyl-3-O-(beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl)-sn-glycerol = 1,2-diacyl-3-O-(beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl)-sn-glycerol + UDP.
UDP-glucose + 1,2-diacyl-sn-glycerol = UDP + 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol.UniRule annotation

Pathwayi: diglucosyl-diacylglycerol biosynthesis

This protein is involved in the pathway diglucosyl-diacylglycerol biosynthesis, which is part of Glycolipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway diglucosyl-diacylglycerol biosynthesis and in Glycolipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCarbohydrate metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00894

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
Processive diacylglycerol beta-glucosyltransferaseUniRule annotation (EC:2.4.1.315)
Alternative name(s):
Beta-diglucosyldiacylglycerol synthaseUniRule annotation
Short name:
Beta-DGSUniRule annotation
Short name:
DGlcDAG synthaseUniRule annotation
Short name:
Glc2-DAG synthaseUniRule annotation
Beta-gentiobiosyldiacylglycerol synthaseUniRule annotation
Beta-monoglucosyldiacylglycerol synthaseUniRule annotation
Short name:
Beta-MGSUniRule annotation
Short name:
MGlcDAG synthaseUniRule annotation
Beta-triglucosyldiacylglycerol synthaseUniRule annotation
Short name:
TGlcDAG synthaseUniRule annotation
Diglucosyl diacylglycerol synthase (1,6-linking)
Glucosyl-beta-1,6-glucosyldiacylglycerol synthaseUniRule annotation
UDP glucosyltransferaseUniRule annotation
UDP-glucose:1,2-diacylglycerol-3-beta-D-glucosyltransferaseUniRule annotation
Gene namesi
Name:ugtPUniRule annotation
Ordered Locus Names:BLi02330, BL01366
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003084521 – 383Processive diacylglycerol beta-glucosyltransferaseAdd BLAST383

Proteomic databases

PRIDEiQ65IA4

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi02330

Structurei

3D structure databases

ProteinModelPortaliQ65IA4
SMRiQ65IA4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. UgtP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108QBV Bacteria
COG0707 LUCA
HOGENOMiHOG000221565
KOiK03429
OMAiEPAGHIV

Family and domain databases

HAMAPiMF_01280 Diacylglyc_glucosyltr, 1 hit
InterProiView protein in InterPro
IPR009695 Diacylglyc_glucosyltr_N
IPR001296 Glyco_trans_1
IPR023589 Pro_diacylglycrl_glcsylTrfase
PfamiView protein in Pfam
PF00534 Glycos_transf_1, 1 hit
PF06925 MGDG_synth, 1 hit

Sequencei

Sequence statusi: Complete.

Q65IA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTNKNILIL TANYGNGHVQ VAKTLYQECE RLGFKNVTVS NLYQESNPIV
60 70 80 90 100
SEITQYLYLK SFSIGKQFYR LFYYGVDKIY NKRKFNIYFK MGNKRLDQLV
110 120 130 140 150
KKHQPDIIIN TFPMIVVPEY RRRMGKVIPT FNVMTDFCLH KIWVHEHIDK
160 170 180 190 200
YYVATDYVKE KLLEIGTHPS NVKITGIPIR RQFEEEMDKD KIYEKYQLSP
210 220 230 240 250
DKKILLIMAG AHGVLKNVKE LCESLVTKED VQVVVVCGKN TMLKSSLEDI
260 270 280 290 300
EALYPNKLRT LGYIERIDEL FRVADCMITK PGGITLTEAT AIGVPVILYK
310 320 330 340 350
PVPGQEKENA LFFEDRGAAI VVNRHEEILE SVSSLLADEK KLNEMKKNIK
360 370 380
SLHLSNSSEV ILTDIIEQSE IIMNKKQTVR ALS
Length:383
Mass (Da):44,168
Last modified:October 25, 2004 - v1
Checksum:i24098768FDF29363
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA Translation: AAU23854.1
AE017333 Genomic DNA Translation: AAU41210.1
RefSeqiWP_003182832.1, NC_006322.1

Genome annotation databases

EnsemblBacteriaiAAU23854; AAU23854; BL01366
AAU41210; AAU41210; BLi02330
GeneIDi3027840
KEGGibld:BLi02330
bli:BL01366

Entry informationi

Entry nameiUGTP_BACLD
AccessioniPrimary (citable) accession number: Q65IA4
Secondary accession number(s): Q62TQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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