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Q65I57

- PANC_BACLD

UniProt

Q65I57 - PANC_BACLD

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Protein

Pantothenate synthetase

Gene
panC, BLi02377, BL02751
Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donor By similarity
Binding sitei61 – 611Beta-alanine By similarity
Binding sitei61 – 611Pantoate By similarity
Binding sitei153 – 1531Pantoate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATP By similarity
Nucleotide bindingi147 – 1504ATP By similarity
Nucleotide bindingi184 – 1874ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-2366-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:BLi02377, BL02751
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Pantothenate synthetaseUniRule annotationPRO_0000128203Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi279010.BL02751.

Structurei

3D structure databases

ProteinModelPortaliQ65I57.
SMRiQ65I57. Positions 1-278.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiEIDYVEV.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65I57-1 [UniParc]FASTAAdd to Basket

« Hide

MIQIYTAKDI QNLTKNYRKE GKTIGFVPTM GFLHEGHMSL VEKARKDNDI    50
VVMSIFVNPM QFGPGEDYEA YPRDIERDRQ LAAGSGVDVL FTPEPEEMYG 100
QEPTVTASVK KRTDVLCGRS REGHFDGVAT VLTKLFNLTS PTRVYFGMKD 150
AQQVAVVDGL INDFFMDIEL IPVETKREED GLAKSSRNVN LRAEERQEAT 200
ALYRALQRGA ELIRNGERDP EAVKREIRSI LEKTSGVIDY ADIYSYPDLE 250
IRDPLTGKVI IAVAVQFSKA RLIDNIIVDI PADQKEDL 288
Length:288
Mass (Da):32,464
Last modified:October 25, 2004 - v1
Checksum:i4A9E5800166A9BDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU41257.1.
CP000002 Genomic DNA. Translation: AAU23903.1.
RefSeqiYP_006713739.1. NC_006322.1.
YP_079541.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU23903; AAU23903; BL02751.
AAU41257; AAU41257; BLi02377.
GeneIDi3029463.
3100430.
KEGGibld:BLi02377.
bli:BL02751.
PATRICi18950412. VBIBacLic203714_2408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017333 Genomic DNA. Translation: AAU41257.1 .
CP000002 Genomic DNA. Translation: AAU23903.1 .
RefSeqi YP_006713739.1. NC_006322.1.
YP_079541.1. NC_006270.3.

3D structure databases

ProteinModelPortali Q65I57.
SMRi Q65I57. Positions 1-278.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279010.BL02751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU23903 ; AAU23903 ; BL02751 .
AAU41257 ; AAU41257 ; BLi02377 .
GeneIDi 3029463.
3100430.
KEGGi bld:BLi02377.
bli:BL02751.
PATRICi 18950412. VBIBacLic203714_2408.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi EIDYVEV.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci BLIC279010:GJ2P-2366-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiPANC_BACLD
AccessioniPrimary (citable) accession number: Q65I57
Secondary accession number(s): Q62TK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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