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Q65I57

- PANC_BACLD

UniProt

Q65I57 - PANC_BACLD

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Protein

Pantothenate synthetase

Gene

panC

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donorUniRule annotation
Binding sitei61 – 611Beta-alanineUniRule annotation
Binding sitei61 – 611PantoateUniRule annotation
Binding sitei153 – 1531PantoateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATPUniRule annotation
Nucleotide bindingi147 – 1504ATPUniRule annotation
Nucleotide bindingi184 – 1874ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-2366-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:BLi02377, BL02751
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Pantothenate synthetasePRO_0000128203Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi279010.BL02751.

Structurei

3D structure databases

ProteinModelPortaliQ65I57.
SMRiQ65I57. Positions 1-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiEIDYVEV.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65I57-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQIYTAKDI QNLTKNYRKE GKTIGFVPTM GFLHEGHMSL VEKARKDNDI
60 70 80 90 100
VVMSIFVNPM QFGPGEDYEA YPRDIERDRQ LAAGSGVDVL FTPEPEEMYG
110 120 130 140 150
QEPTVTASVK KRTDVLCGRS REGHFDGVAT VLTKLFNLTS PTRVYFGMKD
160 170 180 190 200
AQQVAVVDGL INDFFMDIEL IPVETKREED GLAKSSRNVN LRAEERQEAT
210 220 230 240 250
ALYRALQRGA ELIRNGERDP EAVKREIRSI LEKTSGVIDY ADIYSYPDLE
260 270 280
IRDPLTGKVI IAVAVQFSKA RLIDNIIVDI PADQKEDL
Length:288
Mass (Da):32,464
Last modified:October 25, 2004 - v1
Checksum:i4A9E5800166A9BDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU41257.1.
CP000002 Genomic DNA. Translation: AAU23903.1.
RefSeqiYP_006713739.1. NC_006322.1.
YP_079541.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU23903; AAU23903; BL02751.
AAU41257; AAU41257; BLi02377.
GeneIDi3029463.
3100430.
KEGGibld:BLi02377.
bli:BL02751.
PATRICi18950412. VBIBacLic203714_2408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU41257.1 .
CP000002 Genomic DNA. Translation: AAU23903.1 .
RefSeqi YP_006713739.1. NC_006322.1.
YP_079541.1. NC_006270.3.

3D structure databases

ProteinModelPortali Q65I57.
SMRi Q65I57. Positions 1-278.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279010.BL02751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU23903 ; AAU23903 ; BL02751 .
AAU41257 ; AAU41257 ; BLi02377 .
GeneIDi 3029463.
3100430.
KEGGi bld:BLi02377.
bli:BL02751.
PATRICi 18950412. VBIBacLic203714_2408.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi EIDYVEV.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci BLIC279010:GJ2P-2366-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiPANC_BACLD
AccessioniPrimary (citable) accession number: Q65I57
Secondary accession number(s): Q62TK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2004
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3