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Reviewed, UniProtKB/Swiss-Prot Q65I50 (DAPB_BACLD)

Last modified November 25, 2008. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26
Gene names
Name: dapB
Ordered Locus Names: BLi02384, BL02758
OrganismBacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]
Taxonomic identifier279010 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillus

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.

Subcellular location

CytoplasmBy similarity.

Sequence similarities

Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords

   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: HAMAP

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: HAMAP

   Molecular functionbinding

Inferred from electronic annotation. Source: InterPro

dihydrodipicolinate reductase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Dihydrodipicolinate reductase
PRO_0000228324

Sequences

Sequence LengthMass (Da)Tools
Q65I50-1 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 946431974320C510

FASTA26729,165
        10         20         30         40         50         60 
MQKDTIKIAI AGPRGRMGSE AVKLVEDTAH FELVGAIDRT YNREKLSDVM TSSSDAVIYT 

        70         80         90        100        110        120 
DITECFSETS PDVLIDLTTP EIGKLHTKIA LEHGVRPVVG TTGFSESDLN ELMELTDEKG 

       130        140        150        160        170        180 
IGAIIAPNFA LGAVLMMKFS QMAANYFTDV EIIEQHHDQK LDAPSGTALK TAEMISAVRE 

       190        200        210        220        230        240 
AKTQGHPDEK EILPGARGAD QNGIRLHSVR LPGLIAHQEV MFGGDGQTLK IRHDSYNRAS 

       250        260 
FMSGVKLAVE QVMKIDQLVY GLENIIE 

« Hide

References

[1]"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species."
Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. expand/collapse author list , Galleron N., Ehrlich S.D., Berka R.M.
Genome Biol. 5:RESEARCH077.1-RESEARCH077.12(2004) [PubMed: 15461803] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

AE017333 Genomic DNA. Translation: AAU41264.1.
CP000002 Genomic DNA. Translation: AAU23910.1.
RefSeqYP_079548.1.
YP_091957.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3029527.
3100733.
GenomeReviewsGene locus BL02758 in contig CP000002_GR.
Gene locus BLi02384 in contig AE017333_GR.
KEGGbld:BLi02384.
bli:BL02758.
NMPDRfig|279010.5.peg.234.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ65I50.

Enzyme and pathway databases

BioCycBLIC279010:BL02758-MON.

Family and domain databases

HAMAPMF_00102.
[Tree]
InterProIPR000846. DapB.
IPR011770. DapB_bac/pln.
IPR016040. NAD(P)-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR20836. DapB_bac/pln. 1 hit.
PfamPF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view]
ProDomPD004105. DapB. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00036. dapB. 1 hit.
PROSITEPS01298. DAPB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_BACLD
AccessionPrimary (citable) accession number: Q65I50
Secondary accession number(s): Q62TJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 25, 2004
Last modified: November 25, 2008
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents