Reviewed, UniProtKB/Swiss-Prot Q65I33 (TRPC_BACLD)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	BLi02401, BL02773

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Indole-3-glycerol phosphate synthase HAMAP MF_00134		PRO_1000018440

Sequences

	Sequence		Length	Mass (Da)
	Q65I33-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: CDFE44804B64766C	FASTA	252	27,867
	10 20 30 40 50 60 MLNQIIDRKR EDILKIKLSE DLKLPKRSFK KALLSPNRFV ALIAEVKKAS PSKGVIQEGF 70 80 90 100 110 120 EPVKIAKQYE QAKADCLSVL TDTPFFQGKN SYLSDVKRSV SLPVLRKDFI IDSIQVEEAD 130 140 150 160 170 180 RIGADAILLI GEALEPQKLF ELYQQAVEKG MDVLVEVHGE ETLEGILNVF TPEIIGVNNR 190 200 210 220 230 240 NLKNFETTVG QTERMAKLVP PGTVLISESG IGKSEDLTFV KTCGAQAVLV GESLMRETSQ 250 LKAVYALFGE DG

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000002 Genomic DNA. Translation: AAU23927.1. AE017333 Genomic DNA. Translation: AAU41281.1.
RefSeq	YP_079565.1. YP_091974.1.
3D structure databases
HSSP	HSSP built from PDB template 1J5T based on UniProtKB Q56319.
SMR	Q65I33. Positions 1-249.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65I33.
Genome annotation databases
GeneID	3028345. 3100736.
GenomeReviews	Gene locus BLi02401 in contig AE017333_GR. Gene locus BL02773 in contig CP000002_GR.
KEGG	bld:BLi02401. bli:BL02773.
NMPDR	fig|279010.5.peg.251.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
HOGENOM	HBG540956.
OMA	PLLCKDF.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI02401-MONOMER. BLIC279010:BL02773-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BACLD

Accession

Primary (citable) accession number: Q65I33
Secondary accession number(s): Q62TI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 25, 2004
Last modified:	February 9, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)