Reviewed, UniProtKB/Swiss-Prot Q65I29 (AROB_BACLD)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	BLi02405, BL02777

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm Probable HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000231066

Sequences

	Sequence		Length	Mass (Da)
	Q65I29-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 634A636825C01656	FASTA	362	40,201
	10 20 30 40 50 60 MKSLQIETAS LSYPVFIGGG IRKNAAELLS SLNLPMTKLL LITDEEVDKR YGEELFSLLR 70 80 90 100 110 120 SKWPVKKVAV PSGEQAKSID MFMKLQTEAI QFHLDRSSCI VALGGGVVGD LAGFVASTFM 130 140 150 160 170 180 RGIDYVQFPT TLLSHDSAVG GKVAINHPLG KNLIGAFHQP KAVVYDTECL STLPEKEMRS 190 200 210 220 230 240 GLAEVIKHAF IRDESFLNEL LKLDSIEAIT TGQLSEMVYK GISIKAEVVS QDEREQGIRA 250 260 270 280 290 300 YLNFGHTLGH AVEAEYGYGE ITHGDAVALG MQFALFVSEK VLNCPVDRTK IAAWLKNLGY 310 320 330 340 350 360 PESVKREVST EALIYRMMND KKTRGGIIQF VLLDKIGSVR LHSFKAEEIE RWLNMWRLEG DK

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017333 Genomic DNA. Translation: AAU41285.1. CP000002 Genomic DNA. Translation: AAU23931.2.
RefSeq	YP_079569.2. YP_091978.1.
3D structure databases
SMR	Q65I29. Positions 4-353.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65I29.
Genome annotation databases
GeneID	3029357. 3097453.
GenomeReviews	Gene locus BLi02405 in contig AE017333_GR. Gene locus BL02777 in contig CP000002_GR.
KEGG	bld:BLi02405. bli:BL02777.
NMPDR	fig|279010.5.peg.256.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0337.
HOGENOM	HBG632303.
OMA	GYGNITH.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI02405-MONOMER. BLIC279010:BL02777-MONOMER.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BACLD

Accession

Primary (citable) accession number: Q65I29
Secondary accession number(s): Q62TH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 25, 2004
Last modified:	February 9, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)