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Protein

Chorismate synthase

Gene

aroC

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.UniRule annotation

Catalytic activityi

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.UniRule annotation

Cofactori

FMNH2UniRule annotationNote: Reduced FMN (FMNH(2)).UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroD), 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39NADPUniRule annotation1
Binding sitei45NADPUniRule annotation1
Binding sitei298FMN; via amide nitrogenUniRule annotation1
Binding sitei339FMNUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi132 – 134FMNUniRule annotation3
Nucleotide bindingi253 – 254FMNUniRule annotation2
Nucleotide bindingi313 – 317FMNUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandFAD, Flavoprotein, FMN, NADP

Enzyme and pathway databases

UniPathwayiUPA00053; UER00090

Names & Taxonomyi

Protein namesi
Recommended name:
Chorismate synthaseUniRule annotation (EC:4.2.3.5UniRule annotation)
Short name:
CSUniRule annotation
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyaseUniRule annotation
Gene namesi
Name:aroCUniRule annotation
Ordered Locus Names:BLi02406, BL02779
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001405511 – 390Chorismate synthaseAdd BLAST390

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi279010.BLi02406

Structurei

3D structure databases

ProteinModelPortaliQ65I28
SMRiQ65I28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chorismate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D10 Bacteria
COG0082 LUCA
HOGENOMiHOG000060334
KOiK01736
OMAiMLSINAV

Family and domain databases

CDDicd07304 Chorismate_synthase, 1 hit
Gene3Di3.60.150.10, 1 hit
HAMAPiMF_00300 Chorismate_synth, 1 hit
InterProiView protein in InterPro
IPR000453 Chorismate_synth
IPR035904 Chorismate_synth_AroC_sf
IPR020541 Chorismate_synthase_CS
PANTHERiPTHR21085 PTHR21085, 1 hit
PfamiView protein in Pfam
PF01264 Chorismate_synt, 1 hit
PIRSFiPIRSF001456 Chorismate_synth, 1 hit
SUPFAMiSSF103263 SSF103263, 1 hit
TIGRFAMsiTIGR00033 aroC, 1 hit
PROSITEiView protein in PROSITE
PS00787 CHORISMATE_SYNTHASE_1, 1 hit
PS00788 CHORISMATE_SYNTHASE_2, 1 hit
PS00789 CHORISMATE_SYNTHASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q65I28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYLTAGESH GPQLTTIIEG VPAGLYITKE DIDYELQRRQ KGHGRGRRMQ
60 70 80 90 100
IEKDQARITS GVRHGRSLGS PIALVVENND WKHWTKIMGS EPITAEEESE
110 120 130 140 150
MKRQISRPRP GHADLNGAIK YGHRDMRNVL ERSSARETTV RVAAGAVAKK
160 170 180 190 200
ILSQLGIQVA GHVLEIGGVK AEKTNYESIE NLKKVTEESP VRCYDEEAGR
210 220 230 240 250
KMMDAIDEAK ANGDSIGGIV EVIVEGVPVG VGSYVHYDRK LDSKLAAAVL
260 270 280 290 300
SINAFKGVEF GIGFEAARKN GSEVHDEIIW DEEKGYTRAT NRLGGLEGGM
310 320 330 340 350
TTGMPIVVRG VMKPIPTLYK PLKSVDIETK EPFTASIERS DSCAVPAASV
360 370 380 390
VAEAVVAWEI ANAIVEQFGV DQMDRIAENV EKMRKLAREF
Length:390
Mass (Da):42,835
Last modified:October 25, 2004 - v1
Checksum:iF3FC89B14DEA5591
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA Translation: AAU41286.1
CP000002 Genomic DNA Translation: AAU23933.1
RefSeqiWP_003182989.1, NC_006322.1

Genome annotation databases

EnsemblBacteriaiAAU23933; AAU23933; BL02779
AAU41286; AAU41286; BLi02406
GeneIDi3029352
KEGGibld:BLi02406
bli:BL02779

Similar proteinsi

Entry informationi

Entry nameiAROC_BACLD
AccessioniPrimary (citable) accession number: Q65I28
Secondary accession number(s): Q62TH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 25, 2004
Last modified: October 25, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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