Reviewed, UniProtKB/Swiss-Prot Q65I28 (AROC_BACLD)

Names and origin

Protein names

Recommended name:
    Chorismate synthase
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	BLi02406, BL02779

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Chorismate synthase HAMAP MF_00300		PRO_0000140551

Sequences

	Sequence		Length	Mass (Da)
	Q65I28-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: F3FC89B14DEA5591	FASTA	390	42,835
	10 20 30 40 50 60 MRYLTAGESH GPQLTTIIEG VPAGLYITKE DIDYELQRRQ KGHGRGRRMQ IEKDQARITS 70 80 90 100 110 120 GVRHGRSLGS PIALVVENND WKHWTKIMGS EPITAEEESE MKRQISRPRP GHADLNGAIK 130 140 150 160 170 180 YGHRDMRNVL ERSSARETTV RVAAGAVAKK ILSQLGIQVA GHVLEIGGVK AEKTNYESIE 190 200 210 220 230 240 NLKKVTEESP VRCYDEEAGR KMMDAIDEAK ANGDSIGGIV EVIVEGVPVG VGSYVHYDRK 250 260 270 280 290 300 LDSKLAAAVL SINAFKGVEF GIGFEAARKN GSEVHDEIIW DEEKGYTRAT NRLGGLEGGM 310 320 330 340 350 360 TTGMPIVVRG VMKPIPTLYK PLKSVDIETK EPFTASIERS DSCAVPAASV VAEAVVAWEI 370 380 390 ANAIVEQFGV DQMDRIAENV EKMRKLAREF

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:RESEARCH077.1-RESEARCH077.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017333 Genomic DNA. Translation: AAU41286.1. CP000002 Genomic DNA. Translation: AAU23933.1.
RefSeq	YP_079571.1. YP_091979.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q65I28.
Genome annotation databases
GeneID	3029352. 3097454.
GenomeReviews	Gene locus BLi02406 in contig AE017333_GR. Gene locus BL02779 in contig CP000002_GR.
KEGG	bld:BLi02406. bli:BL02779.
NMPDR	fig|279010.5.peg.257.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q65I28.
OMA	PPGLGSH.
Enzyme and pathway databases
BioCyc	BLIC279010:BL02779-MON.
Family and domain databases
HAMAP	MF_00300. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
ProDom	PD002941. Chorismate_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_BACLD

Accession

Primary (citable) accession number: Q65I28
Secondary accession number(s): Q62TH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	October 25, 2004
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)