Q65I08 (KCY_BACLD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	BLi02428, BL02219

Organism

Bacillus licheniformis (strain DSM 13 / ATCC 14580) [Complete proteome] [HAMAP]

Taxonomic identifier

279010 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity HAMAP MF_00238.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	Cytidylate kinase HAMAP MF_00238		PRO_1000048185
Regions
	Nucleotide binding	11 – 19	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65I08 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 42DB40D3E90B8F56	FASTA	226	25,048
	10 20 30 40 50 60 MEKKLCIAID GPAAAGKSTV AKIVARKKSY IYIDTGAMYR AITYLALEKG VDLNDEAALT 70 80 90 100 110 120 ALLKESAIDL TVSPEGEQKV YIAGEDVTEA IRTDSVSNQV SIVAKYAGIR EEMTKRQQQL 130 140 150 160 170 180 AEKGGVVMDG RDIGTHVLPN AEVKIFLLAS VEERAKRRFE ENVKKGYNVN YETLAEEIRR 190 200 210 220 RDKLDSEREI SPLKKADDAL EIDTTSLTID EVAEKILQIV DKKAQK

References

[1]

"The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential." Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G. J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed: 15383718] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

[2]

"Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species." Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J., Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B., Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A., Bolotin A., Lapidus A. , Galleron N., Ehrlich S.D., Berka R.M. Genome Biol. 5:R77.1-R77.12(2004) [PubMed: 15461803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13 / ATCC 14580.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000002 Genomic DNA. Translation: AAU23953.1. AE017333 Genomic DNA. Translation: AAU41306.1.
RefSeq	YP_079591.1. NC_006270.3. YP_091999.1. NC_006322.1.
3D structure databases
HSSP	HSSP built from PDB template 1Q3T based on UniProtKB Q97PK6.
ProteinModelPortal	Q65I08.
SMR	Q65I08. Positions 3-223.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65I08.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000055713; EBBACP00000054244; EBBACG00000055704. EBBACT00000060431; EBBACP00000058864; EBBACG00000060422.
GeneID	3027364. 3097700.
GenomeReviews	Gene locus BLi02428 in contig AE017333_GR. Gene locus BL02219 in contig CP000002_GR.
KEGG	bld:BLi02428. bli:BL02219.
NMPDR	fig|279010.5.peg.294.
PATRIC	18950516. VBIBacLic203714_2460.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0283.
GeneTree	EBGT00050000002974.
HOGENOM	HBG354377.
OMA	DIGTVIC.
PhylomeDB	Q65I08.
ProtClustDB	PRK00023.
Enzyme and pathway databases
BioCyc	BLIC279010-1:BLI02428-MONOMER. BLIC279010:BL02219-MONOMER.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
KO	K00945.
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. Cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_BACLD

Accession

Primary (citable) accession number: Q65I08
Secondary accession number(s): Q62TF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program