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Protein

Anti-sigma F factor

Gene

spoIIAB

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Sporulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-2478-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-sigma F factorUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Stage II sporulation protein ABUniRule annotation
Gene namesi
Name:spoIIABUniRule annotation
Ordered Locus Names:BLi02496, BL00777
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146Anti-sigma F factorPRO_0000203556Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi02496.

Structurei

3D structure databases

ProteinModelPortaliQ65HU3.
SMRiQ65HU3. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBE. Bacteria.
COG2172. LUCA.
HOGENOMiHOG000269931.
KOiK06379.
OMAiHAYEDKI.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00637. Anti_sigma_F. 1 hit.
InterProiIPR010194. Anti-sigma_F.
IPR003594. HATPase_C.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01925. spIIAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65HU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNEMNIQFT ALSQNESFAR VTVAAFIAQL DPTMDELTEI KTVVSEAVTN
60 70 80 90 100
AIIHGYENSG QGNVYISVTL EDHIVYLTIR DEGVGIPNLE EARQPLFTTK
110 120 130 140
PELERSGMGF TIMENFMDDI SIDSSPEMGT TIHLTKHLSK SKALCN
Length:146
Mass (Da):16,198
Last modified:October 25, 2004 - v1
Checksum:iE21BEBC6080524BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU41371.1.
CP000002 Genomic DNA. Translation: AAU24016.1.
RefSeqiWP_009327954.1. NC_006322.1.

Genome annotation databases

EnsemblBacteriaiAAU24016; AAU24016; BL00777.
AAU41371; AAU41371; BLi02496.
GeneIDi3028499.
KEGGibld:BLi02496.
bli:BL00777.
PATRICi18950652. VBIBacLic203714_2528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU41371.1.
CP000002 Genomic DNA. Translation: AAU24016.1.
RefSeqiWP_009327954.1. NC_006322.1.

3D structure databases

ProteinModelPortaliQ65HU3.
SMRiQ65HU3. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BLi02496.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU24016; AAU24016; BL00777.
AAU41371; AAU41371; BLi02496.
GeneIDi3028499.
KEGGibld:BLi02496.
bli:BL00777.
PATRICi18950652. VBIBacLic203714_2528.

Phylogenomic databases

eggNOGiENOG4108ZBE. Bacteria.
COG2172. LUCA.
HOGENOMiHOG000269931.
KOiK06379.
OMAiHAYEDKI.

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-2478-MONOMER.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00637. Anti_sigma_F. 1 hit.
InterProiIPR010194. Anti-sigma_F.
IPR003594. HATPase_C.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01925. spIIAB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSP2AB_BACLD
AccessioniPrimary (citable) accession number: Q65HU3
Secondary accession number(s): Q62T93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 25, 2004
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.