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Protein

Phosphopentomutase

Gene

deoB

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphotransfer between the C1 and C5 carbon atoms of pentose.

Catalytic activityi

Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate.
2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate.

Cofactori

Mn2+Note: Binds 1 or 2 manganese ions.

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Phosphopentomutase (deoB)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15Manganese1
Metal bindingi293Manganese1
Metal bindingi329Manganese1
Metal bindingi330Manganese1
Metal bindingi341Manganese1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00087; UER00173.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopentomutase (EC:5.4.2.7)
Alternative name(s):
Phosphodeoxyribomutase
Gene namesi
Name:deoB
Ordered Locus Names:BLi02500, BL00772
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002582741 – 394PhosphopentomutaseAdd BLAST394

Interactioni

Protein-protein interaction databases

STRINGi279010.BLi02500.

Structurei

3D structure databases

ProteinModelPortaliQ65HT9.
SMRiQ65HT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphopentomutase family.

Phylogenomic databases

eggNOGiENOG4105CZG. Bacteria.
COG1015. LUCA.
HOGENOMiHOG000008159.
KOiK01839.
OMAiCHASGTE.

Family and domain databases

CDDicd16009. PPM. 1 hit.
Gene3Di3.30.70.1250. 1 hit.
3.40.720.10. 1 hit.
HAMAPiMF_00740. Phosphopentomut. 1 hit.
InterProiView protein in InterPro
IPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core_sf.
IPR010045. DeoB.
IPR006124. Metalloenzyme.
IPR024052. Phosphopentomutase_DeoB_cap_sf.
PANTHERiPTHR21110. PTHR21110. 1 hit.
PfamiView protein in Pfam
PF01676. Metalloenzyme. 1 hit.
PIRSFiPIRSF001491. Ppentomutase. 1 hit.
SUPFAMiSSF143856. SSF143856. 1 hit.
SSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR01696. deoB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65HT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAFDYNRVF LIVMDSVGIG EAPDAEKFND KGADTLGHIA EHMGGISLPN
60 70 80 90 100
MAKLGLSNIR EIKGVEKAEK PLAYYGKMKE ASNGKDTMTG HWEIMGLYID
110 120 130 140 150
KPFRVFPEGF PDELIHELEQ KSGRKVIGNK PASGTAILDE LGAEHMETGA
160 170 180 190 200
LIVYTSADSV LQIAAHEEVV PLEELYKICE IARELTLDEK YMVGRVIARP
210 220 230 240 250
FVGKPGEFKR TPNRHDYALK PFDRTVMNEL KDDSFDVIAI GKISDIYDGE
260 270 280 290 300
GITESLRTKS NMDGMDKLVQ TLDKGFTGIS FVNLVDFDAL FGHRRDPEGY
310 320 330 340 350
GKALEEFDAR LPEVFEKMRE DDLLIITADH GNDPVHHGTD HTREYVPLLV
360 370 380 390
YSKKHEKPGA LPLADTFADI GATIADNFKT NMPKYGKSFL SLLK
Length:394
Mass (Da):43,899
Last modified:October 25, 2004 - v1
Checksum:i9E36172283CFB799
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA. Translation: AAU41375.1.
CP000002 Genomic DNA. Translation: AAU24020.1.
RefSeqiWP_003183173.1. NC_006322.1.

Genome annotation databases

EnsemblBacteriaiAAU24020; AAU24020; BL00772.
AAU41375; AAU41375; BLi02500.
GeneIDi3027976.
KEGGibld:BLi02500.
bli:BL00772.

Similar proteinsi

Entry informationi

Entry nameiDEOB_BACLD
AccessioniPrimary (citable) accession number: Q65HT9
Secondary accession number(s): Q62T89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 25, 2004
Last modified: November 22, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families