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Q65HG1

- GCSPB_BACLD

UniProt

Q65HG1 - GCSPB_BACLD

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBLIC279010:GJ2P-2607-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:BLi02629, BL01560
    OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
    Taxonomic identifieri279010 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 485485Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000045688Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei273 – 2731N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiQ65HG1.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi279010.BL01560.

    Structurei

    3D structure databases

    ProteinModelPortaliQ65HG1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiWTGLMMI.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q65HG1-1 [UniParc]FASTAAdd to Basket

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    MNNQDQSLIF EVSKEGRVGY SLPELDVPET DVTDVIDEAY IRDEPADLPE    50
    VSELDIMRHY TALSRRNHGV DSGFYPLGSC TMKYNPKINE KIARIPGFSA 100
    IHPLQDEATV QGALELLYDL SEHLEEITGM DEVTLQPAAG AHGEWTGLMM 150
    IRAFHEANGD HKRTKVIVPD SAHGTNPASA TVAGFETVTV KSNDDGLVDL 200
    EDLKRVVDEE TAALMLTNPN TLGLFEENIL EMAEIVHSAG GKLYYDGANL 250
    NAVLSKARPG DMGFDVVHLN LHKTFTGPHG GGGPGSGPVG VKKELIPYLP 300
    KPVLVKKDGR YTFDHDRPHS IGRVKPYYGN FGINVRAYTY IRSMGPDGLK 350
    EVTENAVLNA NYMMRKLAPY YDLPFDRHSK HEFVLSGRRQ KKLGVRTLDI 400
    AKRLLDFGFH PPTIYFPLNV EECIMIEPTE TESKETLDAF IDTMIQIAKE 450
    AEETPEVVQE APHTTVVKRM DETKAARKPV LRYEK 485
    Length:485
    Mass (Da):54,016
    Last modified:October 25, 2004 - v1
    Checksum:i5039781F70772C8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000002 Genomic DNA. Translation: AAU24144.1.
    AE017333 Genomic DNA. Translation: AAU41503.1.
    RefSeqiYP_006713979.1. NC_006322.1.
    YP_079782.1. NC_006270.3.

    Genome annotation databases

    EnsemblBacteriaiAAU24144; AAU24144; BL01560.
    AAU41503; AAU41503; BLi02629.
    GeneIDi3029135.
    3097435.
    KEGGibld:BLi02629.
    bli:BL01560.
    PATRICi18950940. VBIBacLic203714_2672.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000002 Genomic DNA. Translation: AAU24144.1 .
    AE017333 Genomic DNA. Translation: AAU41503.1 .
    RefSeqi YP_006713979.1. NC_006322.1.
    YP_079782.1. NC_006270.3.

    3D structure databases

    ProteinModelPortali Q65HG1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 279010.BL01560.

    Proteomic databases

    PRIDEi Q65HG1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU24144 ; AAU24144 ; BL01560 .
    AAU41503 ; AAU41503 ; BLi02629 .
    GeneIDi 3029135.
    3097435.
    KEGGi bld:BLi02629.
    bli:BL01560.
    PATRICi 18950940. VBIBacLic203714_2672.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi WTGLMMI.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BLIC279010:GJ2P-2607-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
      Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
      J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13 / ATCC 14580.

    Entry informationi

    Entry nameiGCSPB_BACLD
    AccessioniPrimary (citable) accession number: Q65HG1
    Secondary accession number(s): Q62SW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3