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Q65HG1

- GCSPB_BACLD

UniProt

Q65HG1 - GCSPB_BACLD

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Bacillus licheniformis (strain DSM 13 / ATCC 14580)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBLIC279010:GJ2P-2607-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:BLi02629, BL01560
OrganismiBacillus licheniformis (strain DSM 13 / ATCC 14580)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000606: Chromosome, UP000000608: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000045688Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ65HG1.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi279010.BL01560.

Structurei

3D structure databases

ProteinModelPortaliQ65HG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65HG1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNQDQSLIF EVSKEGRVGY SLPELDVPET DVTDVIDEAY IRDEPADLPE
60 70 80 90 100
VSELDIMRHY TALSRRNHGV DSGFYPLGSC TMKYNPKINE KIARIPGFSA
110 120 130 140 150
IHPLQDEATV QGALELLYDL SEHLEEITGM DEVTLQPAAG AHGEWTGLMM
160 170 180 190 200
IRAFHEANGD HKRTKVIVPD SAHGTNPASA TVAGFETVTV KSNDDGLVDL
210 220 230 240 250
EDLKRVVDEE TAALMLTNPN TLGLFEENIL EMAEIVHSAG GKLYYDGANL
260 270 280 290 300
NAVLSKARPG DMGFDVVHLN LHKTFTGPHG GGGPGSGPVG VKKELIPYLP
310 320 330 340 350
KPVLVKKDGR YTFDHDRPHS IGRVKPYYGN FGINVRAYTY IRSMGPDGLK
360 370 380 390 400
EVTENAVLNA NYMMRKLAPY YDLPFDRHSK HEFVLSGRRQ KKLGVRTLDI
410 420 430 440 450
AKRLLDFGFH PPTIYFPLNV EECIMIEPTE TESKETLDAF IDTMIQIAKE
460 470 480
AEETPEVVQE APHTTVVKRM DETKAARKPV LRYEK
Length:485
Mass (Da):54,016
Last modified:October 25, 2004 - v1
Checksum:i5039781F70772C8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU24144.1.
AE017333 Genomic DNA. Translation: AAU41503.1.
RefSeqiYP_006713979.1. NC_006322.1.
YP_079782.1. NC_006270.3.

Genome annotation databases

EnsemblBacteriaiAAU24144; AAU24144; BL01560.
AAU41503; AAU41503; BLi02629.
GeneIDi3029135.
3097435.
KEGGibld:BLi02629.
bli:BL01560.
PATRICi18950940. VBIBacLic203714_2672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA. Translation: AAU24144.1 .
AE017333 Genomic DNA. Translation: AAU41503.1 .
RefSeqi YP_006713979.1. NC_006322.1.
YP_079782.1. NC_006270.3.

3D structure databases

ProteinModelPortali Q65HG1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 279010.BL01560.

Proteomic databases

PRIDEi Q65HG1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU24144 ; AAU24144 ; BL01560 .
AAU41503 ; AAU41503 ; BLi02629 .
GeneIDi 3029135.
3097435.
KEGGi bld:BLi02629.
bli:BL01560.
PATRICi 18950940. VBIBacLic203714_2672.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BLIC279010:GJ2P-2607-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential."
    Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P., Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 7:204-211(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13 / ATCC 14580.

Entry informationi

Entry nameiGCSPB_BACLD
AccessioniPrimary (citable) accession number: Q65HG1
Secondary accession number(s): Q62SW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3